TRAPPC12 and TRAPPC4

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid)

		TRAPPC12	TRAPPC4
Name		trafficking protein particle complex subunit 12	trafficking protein particle complex subunit 4
Structure		No pdb structure
GO Annotations	Cellular Component	Kinetochore Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cytosol TRAPP Complex Perinuclear Region Of Cytoplasm TRAPPIII Protein Complex	Golgi Membrane Cytoplasm Endoplasmic Reticulum Golgi Apparatus Golgi Stack Cytosol Plasma Membrane Synaptic Vesicle Membrane TRAPP Complex Dendrite Vesicle Synapse Postsynaptic Membrane Presynaptic Active Zone Postsynaptic Density Membrane TRAPPII Protein Complex TRAPPIII Protein Complex
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Organization Vesicle-mediated Transport COPII Vesicle Coating Metaphase Chromosome Alignment Regulation Of Kinetochore Assembly Vesicle Tethering Positive Regulation Of Protein Localization To Kinetochore	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle Coating Autophagy Vesicle-mediated Transport Dendrite Development COPII Vesicle Coating Vesicle Tethering
Pathways		RAB GEFs exchange GTP for GDP on RABs	COPII-mediated vesicle transport Syndecan interactions RAB GEFs exchange GTP for GDP on RABs
Drugs		None	S-palmitoyl-L-cysteine
GWAS		Neuritic plaques or neurofibrillary tangles or cerebral amyloid angiopathy (pleiotropy) ( 29458411 ) Serum immune biomarker levels ( 32066700 )	No GWAS studies recorded
Interacting Genes		13 interacting genes: BMAL1 FBXO7 HNRNPA2B1 LIN7B MTDH RSKR TFCP2 TRAPPC10 TRAPPC3L TRAPPC4 TRAPPC6A TRAPPC6B TRAPPC9	8 interacting genes: APP PRSS23 SDC2 TFIP11 TRAPPC12 TRAPPC2 TRAPPC3L TRAPPC8
Entrez ID		51112	51399
HPRD ID		15580	18220
Ensembl ID		ENSG00000171853	ENSG00000196655
Uniprot IDs		A0A0J9YXQ9 Q8WVT3	B4DF86 E9PKS9 E9PQE8 J3KP27 Q9Y296
PDB IDs		Not available	2J3T 2JSN 2ZMV
GO Terms Enriched among Interactors		TRAPP Complex Vesicle Tethering Vesicle Coating TRAPPII Protein Complex Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Vesicle Transport Vesicle Organization Establishment Of Localization In Cell Vesicle-mediated Transport Intracellular Transport TRAPPIII Protein Complex Cellular Localization COPII Vesicle Coating Golgi Apparatus Intra-Golgi Vesicle-mediated Transport Trans-Golgi Network Endoplasmic Reticulum Cis-Golgi Network Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Oxidative Stress-induced Premature Senescence MiRNA Transport Lewy Body Core Postsynaptic Density Membrane	TRAPP Complex TRAPPIII Protein Complex COPII Vesicle Coating Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle Tethering Vesicle Coating Golgi Vesicle Transport Intracellular Transport Vesicle-mediated Transport Protein-containing Complex Organization Cellular Localization Establishment Of Localization In Cell Endoplasmic Reticulum Lumen Vesicle Organization Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Endoplasmic Reticulum-Golgi Intermediate Compartment Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Golgi Lumen Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Golgi Organization Spliceosomal Complex Disassembly U2-type Post-mRNA Release Spliceosomal Complex Regulation Of Kinetochore Assembly Positive Regulation Of Protein Localization To Kinetochore Protein-containing Complex Assembly Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Golgi Apparatus Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon