TRAPPC12 and TRAPPC6B

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid)

		TRAPPC12	TRAPPC6B
Description		trafficking protein particle complex subunit 12	trafficking protein particle complex subunit 6B
Image		No pdb structure
GO Annotations	Cellular Component	Kinetochore Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cytosol TRAPP Complex Perinuclear Region Of Cytoplasm TRAPPIII Protein Complex	Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cis-Golgi Network Trans-Golgi Network Cytosol TRAPP Complex TRAPPII Protein Complex
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Organization Vesicle-mediated Transport COPII Vesicle Coating Metaphase Chromosome Alignment Regulation Of Kinetochore Assembly Vesicle Tethering Positive Regulation Of Protein Localization To Kinetochore	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle Coating Nervous System Development Golgi Vesicle Transport Vesicle Tethering
Pathways		RAB GEFs exchange GTP for GDP on RABs	COPII-mediated vesicle transport RAB GEFs exchange GTP for GDP on RABs
Drugs			S-palmitoyl-L-cysteine
Diseases
GWAS		Neuritic plaques or neurofibrillary tangles or cerebral amyloid angiopathy (pleiotropy) ( 29458411) Serum immune biomarker levels ( 32066700)
Interacting Genes		13 interacting genes: BMAL1 FBXO7 HNRNPA2B1 LIN7B MTDH RSKR TFCP2 TRAPPC10 TRAPPC3L TRAPPC4 TRAPPC6A TRAPPC6B TRAPPC9	6 interacting genes: SNCA TRAPPC10 TRAPPC12 TRAPPC2 TRAPPC3L TRAPPC6A
Entrez ID		51112	122553
HPRD ID		15580	18221
Ensembl ID		ENSG00000171853	ENSG00000182400
Uniprot IDs		A0A0J9YXQ9 Q8WVT3	Q86SZ2
PDB IDs			2BJN 2CFH 3KXC
Enriched GO Terms of Interacting Partners?		TRAPP Complex Vesicle Tethering Vesicle Coating TRAPPII Protein Complex Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Vesicle Transport Vesicle Organization Establishment Of Localization In Cell Vesicle-mediated Transport Intracellular Transport TRAPPIII Protein Complex Cellular Localization COPII Vesicle Coating Golgi Apparatus Intra-Golgi Vesicle-mediated Transport Trans-Golgi Network Endoplasmic Reticulum Cis-Golgi Network Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Oxidative Stress-induced Premature Senescence MiRNA Transport Lewy Body Core Postsynaptic Density Membrane	TRAPP Complex Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle Tethering Vesicle Coating TRAPPIII Protein Complex Golgi Vesicle Transport COPII Vesicle Coating Vesicle-mediated Transport Establishment Of Localization In Cell Vesicle Organization TRAPPII Protein Complex Intracellular Transport Cellular Localization Intra-Golgi Vesicle-mediated Transport Organelle Organization Endoplasmic Reticulum-Golgi Intermediate Compartment Protein-containing Complex Assembly Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Golgi Apparatus Protein-containing Complex Organization Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Protein Localization To Kinetochore Cytosol Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Regulation Of Kinetochore Assembly Perinuclear Region Of Cytoplasm Negative Regulation Of Dopamine Metabolic Process Regulation Of Serotonin Uptake Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process Dopamine Uptake Involved In Synaptic Transmission Regulation Of Centromere Complex Assembly Response To Iron(II) Ion Regulation Of Chaperone-mediated Autophagy Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Oxidative Phosphorylation Mitochondrial ATP Synthesis Coupled Electron Transport Cuprous Ion Binding Dopamine Biosynthetic Process Negative Regulation Of Cellular Respiration Regulation Of Acyl-CoA Biosynthetic Process Supramolecular Fiber
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