TRAPPC12 and HNRNPA2B1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TRAPPC12	HNRNPA2B1
Description		trafficking protein particle complex subunit 12	heterogeneous nuclear ribonucleoprotein A2/B1
Image		No pdb structure
GO Annotations	Cellular Component	Kinetochore Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cytosol TRAPP Complex Perinuclear Region Of Cytoplasm TRAPPIII Protein Complex	Chromosome, Telomeric Region Extracellular Region Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cajal Body Membrane Nuclear Matrix Extracellular Exosome Catalytic Step 2 Spliceosome Ribonucleoprotein Complex
	Molecular Function	Protein Binding	Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding Protein Binding MiRNA Binding Identical Protein Binding Single-stranded Telomeric DNA Binding DNA Polymerase Binding G-rich Strand Telomeric DNA Binding Molecular Condensate Scaffold Activity N6-methyladenosine-containing RNA Reader Activity
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Organization Vesicle-mediated Transport COPII Vesicle Coating Metaphase Chromosome Alignment Regulation Of Kinetochore Assembly Vesicle Tethering Positive Regulation Of Protein Localization To Kinetochore	MRNA Splicing, Via Spliceosome MRNA Processing MRNA Export From Nucleus RNA Splicing Primary MiRNA Processing DNA Geometric Change RNA Transport MRNA Transport Regulation Of Macromolecule Metabolic Process Positive Regulation Of Telomere Maintenance Via Telomere Lengthening MiRNA Transport
Pathways		RAB GEFs exchange GTP for GDP on RABs	mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs			Copper Artenimol
Diseases
GWAS		Neuritic plaques or neurofibrillary tangles or cerebral amyloid angiopathy (pleiotropy) ( 29458411) Serum immune biomarker levels ( 32066700)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		13 interacting genes: BMAL1 FBXO7 HNRNPA2B1 LIN7B MTDH RSKR TFCP2 TRAPPC10 TRAPPC3L TRAPPC4 TRAPPC6A TRAPPC6B TRAPPC9	105 interacting genes: ARID4B CDKN2A CEBPA CRNDE CSNK2A1 CSNK2B ENY2 ERG ESR1 FBXO11 H3-4 HIPK3 HNRNPL LIG4 LINC00963 LINC01232 MAP4K2 MCPH1 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NEIL3 NR4A1 OGT RNF10 SNRNP70 SREK1 STAT5B SUMO2 TRAPPC12 TRIM35 TTF2 VHL WEE2-AS1 YAE1 ZMYM2
Entrez ID		51112	3181
HPRD ID		15580	02526
Ensembl ID		ENSG00000171853	ENSG00000122566
Uniprot IDs		A0A0J9YXQ9 Q8WVT3	A0A7I2V4N1 P22626
PDB IDs			1X4B 5EN1 5HO4 5WWE 5WWF 5WWG 6WPQ 6WQK 7WM3 8DU2 8DUW 8EC7 8HNI
Enriched GO Terms of Interacting Partners?		TRAPP Complex Vesicle Tethering Vesicle Coating TRAPPII Protein Complex Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Vesicle Transport Vesicle Organization Establishment Of Localization In Cell Vesicle-mediated Transport Intracellular Transport TRAPPIII Protein Complex Cellular Localization COPII Vesicle Coating Golgi Apparatus Intra-Golgi Vesicle-mediated Transport Trans-Golgi Network Endoplasmic Reticulum Cis-Golgi Network Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Oxidative Stress-induced Premature Senescence MiRNA Transport Lewy Body Core Postsynaptic Density Membrane	MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Negative Regulation Of Translation Regulation Of Gene Expression Negative Regulation Of Cell Migration MRNA Destabilization Regulation Of Macromolecule Biosynthetic Process RNA Destabilization Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Regulation Of Macromolecule Metabolic Process Positive Regulation Of MRNA Catabolic Process Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Angiogenesis Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Vasculature Development Negative Regulation Of Cytokine Production Negative Regulation Of Developmental Process Regulation Of Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Angiogenesis Negative Regulation Of Multicellular Organismal Process Regulation Of Vasculature Development Regulation Of Translation Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of MRNA Stability Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of RNA Stability Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Signaling
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