TRAPPC12 and TRAPPC10

Number of citations: 43 (PubMedID 21525244)
Data Source: BioGRID (two hybrid)

		TRAPPC12	TRAPPC10
Name		trafficking protein particle complex subunit 12	trafficking protein particle complex subunit 10
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Kinetochore Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cytosol TRAPP Complex Perinuclear Region Of Cytoplasm TRAPPIII Protein Complex	Cytoplasm Golgi Apparatus Cytosol TRAPP Complex TRAPPII Protein Complex
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Organization Vesicle-mediated Transport COPII Vesicle Coating Metaphase Chromosome Alignment Regulation Of Kinetochore Assembly Vesicle Tethering Positive Regulation Of Protein Localization To Kinetochore	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Intra-Golgi Vesicle-mediated Transport Vesicle Coating Vesicle-mediated Transport Early Endosome To Golgi Transport Golgi Vesicle Transport Vesicle Tethering
Pathways		RAB GEFs exchange GTP for GDP on RABs	COPII-mediated vesicle transport RAB GEFs exchange GTP for GDP on RABs
GWAS		Neuritic plaques or neurofibrillary tangles or cerebral amyloid angiopathy (pleiotropy) ( 29458411 ) Serum immune biomarker levels ( 32066700 )	No GWAS studies recorded
Novel Interactors		None recorded	10 novel interactors: GET1 SLC19A1 SUMO3 TFF1 TFF2 TFF3 TMPRSS2 TRPM2 U2AF1 UBE2G2
Interacting Genes		13 interacting genes: BMAL1 FBXO7 HNRNPA2B1 LIN7B MTDH RSKR TFCP2 TRAPPC10 TRAPPC3L TRAPPC4 TRAPPC6A TRAPPC6B TRAPPC9	5 interacting genes: TRAPPC12 TRAPPC3L TRAPPC6A TRAPPC6B TRAPPC8
Entrez ID		51112	7109
HPRD ID		15580	03656
Ensembl ID		ENSG00000171853	ENSG00000160218
Uniprot IDs		A0A0J9YXQ9 Q8WVT3	P48553
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		TRAPP Complex Vesicle Tethering Vesicle Coating TRAPPII Protein Complex Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Vesicle Transport Vesicle Organization Establishment Of Localization In Cell Vesicle-mediated Transport Intracellular Transport TRAPPIII Protein Complex Cellular Localization COPII Vesicle Coating Golgi Apparatus Intra-Golgi Vesicle-mediated Transport Trans-Golgi Network Endoplasmic Reticulum Cis-Golgi Network Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Oxidative Stress-induced Premature Senescence MiRNA Transport Lewy Body Core Postsynaptic Density Membrane	TRAPP Complex Vesicle Tethering Vesicle Coating Endoplasmic Reticulum To Golgi Vesicle-mediated Transport TRAPPIII Protein Complex Maintenance Of Gastrointestinal Epithelium COPII Vesicle Coating Golgi Vesicle Transport Epithelial Structure Maintenance Digestive System Process Vesicle Organization Anatomical Structure Homeostasis Tissue Homeostasis Methotrexate Transport Methotrexate Transmembrane Transporter Activity Folate:monoatomic Anion Antiporter Activity Multicellular Organismal-level Homeostasis CXCR4 Chemokine Receptor Binding Mono-ADP-D-ribose Binding Cis-Golgi Network Cellular Localization Establishment Of Localization In Cell Folate Import Across Plasma Membrane 2',3'-cyclic GMP-AMP Binding Cyclic-GMP-AMP Transmembrane Transporter Activity Cellular Response To Temperature Stimulus Positive Regulation Of Protein Localization To Kinetochore Folic Acid Transmembrane Transporter Activity Folate Transmembrane Transport Entry Receptor-mediated Virion Attachment To Host Cell GET Complex Vesicle-mediated Transport Intracellular Transport Regulation Of Kinetochore Assembly Negative Regulation Of Gastric Acid Secretion Viral Translation ADP-ribose Diphosphatase Activity