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MECR and RXRA
Number of citations of the paper that reports this interaction (PMID
9795230
)
4
Data Source:
HPRD
(two hybrid)
MECR
RXRA
Gene Name
mitochondrial trans-2-enoyl-CoA reductase
retinoid X receptor, alpha
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Mitochondrion
Nuclear Chromatin
Nucleus
Nucleoplasm
Receptor Complex
RNA Polymerase II Transcription Factor Complex
Molecular Function
Zinc Ion Binding
Trans-2-enoyl-CoA Reductase (NADPH) Activity
RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Steroid Hormone Receptor Activity
Retinoic Acid Receptor Activity
Transcription Coactivator Activity
Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity
9-cis Retinoic Acid Receptor Activity
Protein Binding
Zinc Ion Binding
Enzyme Binding
Chromatin DNA Binding
Vitamin D Receptor Binding
Sequence-specific DNA Binding
Transcription Regulatory Region DNA Binding
Retinoic Acid-responsive Element Binding
Protein Heterodimerization Activity
Vitamin D Response Element Binding
Biological Process
Fatty Acid Metabolic Process
Fatty Acid Biosynthetic Process
Oxidation-reduction Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
In Utero Embryonic Development
Maternal Placenta Development
Transcription Initiation From RNA Polymerase II Promoter
Vitamin Metabolic Process
Embryo Implantation
Cholesterol Metabolic Process
Gene Expression
Modulation By Virus Of Host Morphology Or Physiology
Response To Retinoic Acid
Peroxisome Proliferator Activated Receptor Signaling Pathway
Camera-type Eye Development
Steroid Hormone Mediated Signaling Pathway
Cellular Lipid Metabolic Process
Small Molecule Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Translational Initiation By Iron
Retinoic Acid Receptor Signaling Pathway
Protein Homotetramerization
Ventricular Cardiac Muscle Tissue Morphogenesis
Ventricular Cardiac Muscle Cell Differentiation
Transmembrane Transport
Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development
Regulation Of Branching Involved In Prostate Gland Morphogenesis
Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus
Pathways
Bile acid and bile salt metabolism
Metabolism of lipids and lipoproteins
Nuclear Receptor transcription pathway
Metabolic disorders of biological oxidation enzymes
Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)
Generic Transcription Pathway
Endogenous sterols
Synthesis of bile acids and bile salts
Orphan transporters
Defective FMO3 causes Trimethylaminuria (TMAU)
Signaling by Retinoic Acid
Recycling of bile acids and salts
Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)
Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
Defective CYP19A1 causes Aromatase excess syndrome (AEXS)
Regulation of pyruvate dehydrogenase (PDH) complex
Pyruvate metabolism
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
Defective MAOA causes Brunner syndrome (BRUNS)
Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Activation of gene expression by SREBF (SREBP)
The citric acid (TCA) cycle and respiratory electron transport
Transcriptional activation of mitochondrial biogenesis
PPARA activates gene expression
Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)
Organelle biogenesis and maintenance
Import of palmitoyl-CoA into the mitochondrial matrix
Pyruvate metabolism and Citric Acid (TCA) cycle
Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)
Phase 1 - Functionalization of compounds
RORA activates circadian gene expression
Regulation of cholesterol biosynthesis by SREBP (SREBF)
Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)
Cytochrome P450 - arranged by substrate type
Transcriptional regulation of white adipocyte differentiation
Biological oxidations
Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)
Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
Fatty acid, triacylglycerol, and ketone body metabolism
Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)
Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)
REV-ERBA represses gene expression
Defective CYP1B1 causes Glaucoma
Mitochondrial biogenesis
Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)
Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)
YAP1- and WWTR1 (TAZ)-stimulated gene expression
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs
Adapalene
Bexarotene
Acitretin
Alitretinoin
Etodolac
Etretinate
(5BETA)-PREGNANE-3,20-DIONE
2-chloro-5-nitro-N-phenylbenzamide
1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONE
2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID
tributylstannanyl
Diseases
GWAS
Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) (
23648065
)
Central corneal thickness (
22814818
23493294
)
Corneal structure (
23291589
)
Crohn's disease (need for surgery) (
23665963
)
Intelligence (
22449649
)
Protein-Protein Interactions
5 interactors:
HNF4A
PPARA
RARA
RXRA
THRB
113 interactors:
ACVR1
ACVR1B
ALOX15B
ARID5A
ARNTL
BCL3
BRD8
CASP2
CHD9
CLOCK
CNOT1
COPS2
CSNK2B
CTCF
CTNNB1
CTSL
DNTTIP2
EDF1
ESR1
ESR2
FUS
GADD45A
GADD45G
GATA2
GK
GRIP1
GSK3B
HDAC3
HDAC4
HMGA1
IGFBP3
ITGB3BP
JAZF1
JMJD1C
KIF1A
MAPK1
MAPK3
MAPK7
MECR
MED1
MED24
MED25
MPG
MYOD1
NCOA1
NCOA2
NCOA3
NCOA4
NCOA6
NCOR1
NCOR2
NFKB1
NFKBIB
NPAS2
NR0B2
NR1H2
NR1H3
NR1H4
NR1I2
NR1I3
NR2E3
NR2F1
NR2F6
NR3C2
NR4A2
NRBF2
NRIP1
NSD1
PARP1
PLK1
PML
POU2F1
POU2F2
PPARA
PPARD
PPARG
PPARGC1A
PRKD2
PRMT2
PSMC3IP
PSMC5
RAD54L2
RARA
RARB
RARG
RELA
RNF8
ROBO4
RPS6KA6
SMAD2
SMARCD3
SMN1
SNW1
SP1
SRC
SRF
STAT1
TADA3
TAF11
TAF1B
TBP
TDG
THRA
THRB
TK1
TMPRSS3
TRIM24
TRIP10
TRIP4
UBQLN4
VDR
ZBTB16
ZNHIT3
Entrez ID
51102
6256
HPRD ID
12192
01577
Ensembl ID
ENSG00000116353
Uniprot IDs
Q9BV79
F1D8Q5
P19793
Q6P3U7
PDB IDs
1ZSY
2VCY
1BY4
1DSZ
1FBY
1FM6
1FM9
1G1U
1G5Y
1K74
1LBD
1MV9
1MVC
1MZN
1R0N
1RDT
1RXR
1XLS
1XV9
1XVP
1YNW
2ACL
2NLL
2P1T
2P1U
2P1V
2ZXZ
2ZY0
3DZU
3DZY
3E00
3E94
3FAL
3FC6
3FUG
3H0A
3KWY
3NSP
3NSQ
3OAP
3OZJ
3PCU
3R29
3R2A
3R5M
3UVV
4J5W
4J5X
Enriched GO Terms of Interacting Partners
?
Steroid Hormone Mediated Signaling Pathway
Hormone-mediated Signaling Pathway
Transcription Initiation From RNA Polymerase II Promoter
Cellular Response To Steroid Hormone Stimulus
Intracellular Receptor Signaling Pathway
DNA-templated Transcription, Initiation
Cellular Response To Organic Cyclic Compound
Cellular Response To Lipid
Response To Steroid Hormone
Cellular Response To Hormone Stimulus
Response To Lipid
Transcription From RNA Polymerase II Promoter
Response To Organic Cyclic Compound
Response To Hormone
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Response To Organic Substance
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Transcription, DNA-templated
Retinoic Acid Receptor Signaling Pathway
RNA Biosynthetic Process
Ventricular Cardiac Muscle Cell Differentiation
Response To Organic Substance
Organ Morphogenesis
Positive Regulation Of Cellular Metabolic Process
Regulation Of Lipid Metabolic Process
Epithelium Development
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Organ Development
Glandular Epithelial Cell Differentiation
Reproductive Process
Negative Regulation Of Gene Expression
RNA Metabolic Process
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Metabolic Process
Gene Expression
Prostate Gland Development
Cellular Macromolecule Biosynthetic Process
Regulation Of Translational Initiation
Macromolecule Biosynthetic Process
Heart Development
Epithelial Cell Differentiation
Tissue Development
System Development
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Gene Expression
Transcription, DNA-templated
RNA Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Intracellular Receptor Signaling Pathway
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Transcription Initiation From RNA Polymerase II Promoter
Transcription From RNA Polymerase II Promoter
Regulation Of Transcription, DNA-templated
DNA-templated Transcription, Initiation
Regulation Of Transcription From RNA Polymerase II Promoter
RNA Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Regulation Of Nitrogen Compound Metabolic Process
Gene Expression
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Gene Expression
Regulation Of Gene Expression
Cellular Macromolecule Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Biosynthetic Process
Macromolecule Biosynthetic Process
Positive Regulation Of Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Cellular Metabolic Process
Regulation Of Metabolic Process
Cellular Response To Hormone Stimulus
Biosynthetic Process
Nitrogen Compound Metabolic Process
Cellular Response To Lipid
Cellular Response To Steroid Hormone Stimulus
Response To Hormone
Steroid Hormone Mediated Signaling Pathway
Hormone-mediated Signaling Pathway
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Response To Steroid Hormone
Cellular Response To Organic Cyclic Compound
Response To Lipid
Cellular Response To Organic Substance
Response To Organic Substance
Cellular Metabolic Process
Tagcloud
?
17q
22cm
canine
centromeric
cfa9
correspond
cosmid
cryba1
distal
dog
grp78
hsa17
hsa17q
hsa9q
hsa9q34
hspa5
lies
linkage
loci
map
mmu2
nf1
occupy
painting
places
probable
syntenic
telomeric
thirds
Tagcloud (Difference)
?
17q
22cm
canine
centromeric
cfa9
correspond
cosmid
cryba1
distal
dog
grp78
hsa17
hsa17q
hsa9q
hsa9q34
hspa5
lies
linkage
loci
map
mmu2
nf1
occupy
painting
places
probable
syntenic
telomeric
thirds
Tagcloud (Intersection)
?