MECR

Description		mitochondrial trans-2-enoyl-CoA reductase
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Membrane
	Molecular Function	Oxidoreductase Activity Enoyl-[acyl-carrier-protein] Reductase (NADPH) Activity
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Intracellular Iron Ion Homeostasis Ceramide Biosynthetic Process
Pathways		Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA
Drugs
Diseases
GWAS		Carotid plaque maximum area ( 32469969) Diastolic blood pressure ( 30224653) Low density lipoprotein cholesterol levels ( 32154731) Mean area of carotid plaque ( 32469969) Schizophrenia ( 26531332) Tourette syndrome ( 30818990)
Novel Interacting Genes		2 novel interacting genes: MTOR SLC45A1
Interacting Genes		5 interacting genes: HNF4A PPARA RARA RXRA THRB
Entrez ID		51102
HPRD ID		12192
Ensembl ID		ENSG00000116353
Uniprot IDs		Q9BV79
PDB IDs		1ZSY 2VCY 7AYB 7AYC
Enriched GO Terms of Interacting Partners?		Nuclear Receptor Activity Intracellular Receptor Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Retinoic Acid Receptor Signaling Pathway RNA Polymerase II Transcription Regulator Complex Hormone-mediated Signaling Pathway Sequence-specific DNA Binding Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway MRNA Transcription By RNA Polymerase II Transcription Coactivator Binding MRNA Transcription DNA-binding Transcription Factor Activity Macromolecule Biosynthetic Process Regulation Of Thyroid Hormone Receptor Signaling Pathway Transcription By RNA Polymerase II Retinoic Acid-responsive Element Binding Nuclear Protein Quality Control By The Ubiquitin-proteasome System Regulation Of Lipid Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Intracellular Signal Transduction Positive Regulation Of RNA Metabolic Process Regulation Of Circadian Rhythm Peroxisome Proliferator Activated Receptor Signaling Pathway RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Lipid Metabolic Process Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Response To Nutrient Negative Regulation Of Macromolecule Biosynthetic Process Retinoic Acid Binding Negative Regulation Of Biosynthetic Process Nuclear Steroid Receptor Activity Positive Regulation Of Transcription By RNA Polymerase II Cell Differentiation Negative Regulation Of DNA-templated Transcription Sequence-specific Double-stranded DNA Binding Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of MiRNA Transcription Response To Hormone Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Multicellular Organismal Development Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Regulation Of Response To Nutrient Levels Positive Regulation Of Biosynthetic Process Positive Regulation Of ATP Metabolic Process
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