MECR and HNF4A

Number of citations of the paper that reports this interaction (PubMedID 9795230)
0

Data Source:
HPRD (two hybrid)

		MECR	HNF4A
Description		mitochondrial trans-2-enoyl-CoA reductase	hepatocyte nuclear factor 4 alpha
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Membrane	Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Oxidoreductase Activity Enoyl-[acyl-carrier-protein] Reductase (NADPH) Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Signaling Receptor Binding Fatty Acid Binding Protein Binding Zinc Ion Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Intracellular Iron Ion Homeostasis Ceramide Biosynthetic Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Lipid Metabolic Process Xenobiotic Metabolic Process Sex Differentiation Blood Coagulation Negative Regulation Of Cell Population Proliferation Response To Glucose Gene Expression Regulation Of Gastrulation Regulation Of Lipid Metabolic Process Signal Transduction Involved In Regulation Of Gene Expression Cell Differentiation Negative Regulation Of Cell Growth Intracellular Receptor Signaling Pathway Glucose Homeostasis Cholesterol Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Regulation Of Insulin Secretion Lipid Homeostasis Phospholipid Homeostasis Regulation Of Growth Hormone Receptor Signaling Pathway Triglyceride Homeostasis Regulation Of Ornithine Metabolic Process
Pathways		Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA	Nuclear Receptor transcription pathway Nephron development
Drugs			Lauric acid AVI-4557 Myristic acid
Diseases			Maturity onset diabetes of the young (MODY)
GWAS		Carotid plaque maximum area ( 32469969) Diastolic blood pressure ( 30224653) Low density lipoprotein cholesterol levels ( 32154731) Mean area of carotid plaque ( 32469969) Schizophrenia ( 26531332) Tourette syndrome ( 30818990)	Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) C-reactive protein ( 22939635) C-reactive protein levels ( 29878111 30388399 21300955) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 20686565 24097068) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coenzyme Q10 levels ( 27149984) Estimated glomerular filtration rate ( 31152163) Factor VII activity ( 30642921) Fibrinogen levels ( 26561523 28107422) Gallstone disease ( 30504769) Granulocyte count ( 27863252) HDL cholesterol ( 25961943 24097068 20686565 30275531 19060906) HDL cholesterol levels ( 30698716 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High density lipoprotein cholesterol levels ( 33339817) LDL cholesterol levels ( 32203549) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte percentage of white cells ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Metabolic syndrome ( 31589552) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Neutrophil percentage of white cells ( 27863252 32888494) Pancreatic cancer ( 29422604) Red blood cell count ( 32888494) Serum uric acid levels ( 30993211) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Total cholesterol levels ( 33339817) Type 2 diabetes ( 31118516 30718926 30297969 30054458 32499647 29632382 28869590 24509480 22158537 21874001) Type 2 diabetes (adjusted for BMI) ( 29632382) Ulcerative colitis ( 23128233 19915572) Urate levels ( 31578528) White blood cell count ( 32888494)
Interacting Genes		5 interacting genes: HNF4A PPARA RARA RXRA THRB	70 interacting genes: ANP32B ARNT COPS5 CREBBP CTNNB1 DDX3X DMD EIF1AY ESR1 FOXO1 GTF2B GTF2H1 HDAC3 HDAC4 HIF1A HNF1A ISL1 MAPK1 MAPK14 MAPK3 MECR MED1 MED10 MED14 MED16 MED17 MED21 MED24 MED7 NCOA1 NCOA2 NCOA6 NCOR2 NPPA NR0B2 NR1I2 NR1I3 NR2C2 NR2F1 NRBF2 NRIP1 PCBD1 PIAS4 PLPP2 PNRC1 PNRC2 PPARGC1A PPARGC1B PRKAA2 PRKACA PRMT1 PROX1 RNF4 SIRT1 SMAD2 SMAD3 SMAD4 SP1 SREBF1 SREBF2 SUB1 TAF6 TAF9 TBP TGS1 TP53 TRIM24 UBE2I XPO1 ZNHIT3
Entrez ID		51102	3172
HPRD ID		12192	02612
Ensembl ID		ENSG00000116353	ENSG00000101076
Uniprot IDs		Q9BV79	B9VVT8 F1D8S2 F1D8T0 F1D8T1 P41235
PDB IDs		1ZSY 2VCY 7AYB 7AYC	1PZL 3CBB 3FS1 4B7W 4IQR 6CHT 8C1L
Enriched GO Terms of Interacting Partners?		Nuclear Receptor Activity Intracellular Receptor Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Retinoic Acid Receptor Signaling Pathway RNA Polymerase II Transcription Regulator Complex Hormone-mediated Signaling Pathway Sequence-specific DNA Binding Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway MRNA Transcription By RNA Polymerase II Transcription Coactivator Binding MRNA Transcription DNA-binding Transcription Factor Activity Macromolecule Biosynthetic Process Regulation Of Thyroid Hormone Receptor Signaling Pathway Transcription By RNA Polymerase II Retinoic Acid-responsive Element Binding Nuclear Protein Quality Control By The Ubiquitin-proteasome System Regulation Of Lipid Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Intracellular Signal Transduction Positive Regulation Of RNA Metabolic Process Regulation Of Circadian Rhythm Peroxisome Proliferator Activated Receptor Signaling Pathway RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Lipid Metabolic Process Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Response To Nutrient Negative Regulation Of Macromolecule Biosynthetic Process Retinoic Acid Binding Negative Regulation Of Biosynthetic Process Nuclear Steroid Receptor Activity Positive Regulation Of Transcription By RNA Polymerase II Cell Differentiation Negative Regulation Of DNA-templated Transcription Sequence-specific Double-stranded DNA Binding Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of MiRNA Transcription Response To Hormone Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Multicellular Organismal Development Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Regulation Of Response To Nutrient Levels Positive Regulation Of Biosynthetic Process Positive Regulation Of ATP Metabolic Process	Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Nuclear Receptor Binding Regulation Of Gene Expression Nucleus Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Transcription Coactivator Activity Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Transcription Initiation By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Regulation Of Metabolic Process Chromatin Positive Regulation Of DNA-templated Transcription Initiation Nucleobase-containing Compound Biosynthetic Process Transcription Preinitiation Complex Assembly DNA-templated Transcription Transcription By RNA Polymerase II Macromolecule Biosynthetic Process RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex Negative Regulation Of Macromolecule Metabolic Process Nucleic Acid Metabolic Process Nuclear Thyroid Hormone Receptor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Transcription Coregulator Activity Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process DNA-binding Transcription Factor Binding Nucleobase-containing Compound Metabolic Process Mediator Complex
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