PLIN1 and BSCL2

Number of citations of the paper that reports this interaction (PubMedID 30940487)
55

Data Source:
BioGRID (affinity chromatography technology, protein complementation assay)

		PLIN1	BSCL2
Description		perilipin 1	BSCL2 lipid droplet biogenesis associated, seipin
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Lipid Droplet Cytosol	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Membrane
	Molecular Function	Protein Binding Lipid Binding	Protein Binding Phospholipid Binding
	Biological Process	Lipid Metabolic Process Lipid Catabolic Process Cellular Response To Cold	Lipid Metabolic Process Lipid Catabolic Process Lipid Storage Lipid Droplet Organization Fat Cell Differentiation Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Cold-induced Thermogenesis Lipid Droplet Formation
Pathways		Triglyceride catabolism Transcriptional regulation of white adipocyte differentiation NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases			Congenital generalized lipodystrophy (CGL) Distal hereditary motor neuropathies (dHMN) Hereditary spastic paraplegia (SPG)
GWAS		HDL cholesterol ( 30275531)	Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		4 interacting genes: ABHD5 BSCL2 LIPE PRKACA	37 interacting genes: ANKRD46 B4GALNT2 BMP10 CLDN19 CMTM7 CPEB2 CXCL9 CYSRT1 ERMP1 GABARAPL1 GMCL1 HOXA1 KRTAP6-3 LAT MALL NSG1 OLFM4 PLEKHF2 PLIN1 RPRM SERP1 SERP2 SFTPC SMIM3 SMLR1 SPMIP9 STRIT1 TMEM19 TMEM218 TMEM222 TRAM1L1 TRARG1 TRIM54 TSPAN2 UPK2 USE1 VAMP3
Entrez ID		5346	26580
HPRD ID		01364	05858
Ensembl ID		ENSG00000166819	ENSG00000168000
Uniprot IDs		O60240	A0A024R549 J3KQ12 Q96G97
PDB IDs			6DS5
Enriched GO Terms of Interacting Partners?		Lipid Droplet Triacylglycerol Lipase Activity Regulation Of Lipid Metabolic Process Regulation Of Lipid Catabolic Process Lipid Metabolic Process Sterol Ester Esterase Activity Diacylglycerol Lipase Activity All-trans-retinyl-palmitate Hydrolase, All-trans-retinol Forming Activity Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Protein Localization To Lipid Droplet Positive Regulation Of Lipid Metabolic Process Negative Regulation Of Triglyceride Storage Lipase Activator Activity Retinyl-palmitate Esterase Activity Lipid Catabolic Process Diacylglycerol Catabolic Process CAMP-dependent Protein Kinase Activity Monoacylglycerol Lipase Activity Phosphate-containing Compound Metabolic Process Glycerolipid Metabolic Process Protein Phosphorylation CAMP-dependent Protein Kinase Complex Cellular Response To Parathyroid Hormone Stimulus Cellular Response To Glucagon Stimulus High-density Lipoprotein Particle Assembly Mitochondrial Protein Catabolic Process CAMP/PKA Signal Transduction Nucleotide-activated Protein Kinase Complex Channel Activator Activity Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Lysophosphatidic Acid Acyltransferase Activity Positive Regulation Of Triglyceride Catabolic Process Interleukin-2-mediated Signaling Pathway Cellular Response To Epinephrine Stimulus Negative Regulation Of Catabolic Process Phosphorylation Lipase Activity Ether Lipid Metabolic Process Diacylglycerol Metabolic Process Triglyceride Catabolic Process Acylglycerol Catabolic Process Catabolic Process Regulation Of Hormone Levels Protein-lipid Complex Assembly Protein Serine/threonine/tyrosine Kinase Activity Regulation Of Cardiac Conduction Vascular Endothelial Cell Response To Fluid Shear Stress Negative Regulation Of Glycolytic Process Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Interleukin-2 Production
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