PLIN1 and LIPE

Number of citations of the paper that reports this interaction (PubMedID 19717842)
46

Data Source:
BioGRID (fluorescent resonance energy transfer, protein complementation assay, fluorescent resonance energy transfer, affinity chromatography technology)

		PLIN1	LIPE
Description		perilipin 1	lipase E, hormone sensitive type
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Lipid Droplet Cytosol	Cytoplasm Lipid Droplet Cytosol Plasma Membrane Caveola Membrane
	Molecular Function	Protein Binding Lipid Binding	Sterol Ester Esterase Activity Triacylglycerol Lipase Activity Protein Binding Lipase Activity Hydrolase Activity Monoacylglycerol Lipase Activity All-trans-retinyl-palmitate Hydrolase, All-trans-retinol Forming Activity Retinyl-palmitate Esterase Activity Diacylglycerol Lipase Activity
	Biological Process	Lipid Metabolic Process Lipid Catabolic Process Cellular Response To Cold	Protein Phosphorylation Lipid Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Lipid Catabolic Process Triglyceride Catabolic Process Retinol Metabolic Process Diacylglycerol Catabolic Process Ether Lipid Metabolic Process
Pathways		Triglyceride catabolism Transcriptional regulation of white adipocyte differentiation NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Triglyceride catabolism MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases
GWAS		HDL cholesterol ( 30275531)
Interacting Genes		4 interacting genes: ABHD5 BSCL2 LIPE PRKACA	11 interacting genes: FABP4 KATNA1 MAPK1 MAPK3 MTNR1A NSFL1C PLIN1 PLIN5 PRKACA STAR TSGA10IP
Entrez ID		5346	3991
HPRD ID		01364	01062
Ensembl ID		ENSG00000166819	ENSG00000079435
Uniprot IDs		O60240	A8K8W7 Q05469
PDB IDs
Enriched GO Terms of Interacting Partners?		Lipid Droplet Triacylglycerol Lipase Activity Regulation Of Lipid Metabolic Process Regulation Of Lipid Catabolic Process Lipid Metabolic Process Sterol Ester Esterase Activity Diacylglycerol Lipase Activity All-trans-retinyl-palmitate Hydrolase, All-trans-retinol Forming Activity Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Protein Localization To Lipid Droplet Positive Regulation Of Lipid Metabolic Process Negative Regulation Of Triglyceride Storage Lipase Activator Activity Retinyl-palmitate Esterase Activity Lipid Catabolic Process Diacylglycerol Catabolic Process CAMP-dependent Protein Kinase Activity Monoacylglycerol Lipase Activity Phosphate-containing Compound Metabolic Process Glycerolipid Metabolic Process Protein Phosphorylation CAMP-dependent Protein Kinase Complex Cellular Response To Parathyroid Hormone Stimulus Cellular Response To Glucagon Stimulus High-density Lipoprotein Particle Assembly Mitochondrial Protein Catabolic Process CAMP/PKA Signal Transduction Nucleotide-activated Protein Kinase Complex Channel Activator Activity Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Lysophosphatidic Acid Acyltransferase Activity Positive Regulation Of Triglyceride Catabolic Process Interleukin-2-mediated Signaling Pathway Cellular Response To Epinephrine Stimulus Negative Regulation Of Catabolic Process Phosphorylation Lipase Activity Ether Lipid Metabolic Process Diacylglycerol Metabolic Process Triglyceride Catabolic Process Acylglycerol Catabolic Process Catabolic Process Regulation Of Hormone Levels Protein-lipid Complex Assembly Protein Serine/threonine/tyrosine Kinase Activity Regulation Of Cardiac Conduction Vascular Endothelial Cell Response To Fluid Shear Stress Negative Regulation Of Glycolytic Process Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Interleukin-2 Production	Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of Steroid Metabolic Process Positive Regulation Of Lipid Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Positive Regulation Of Steroid Biosynthetic Process Regulation Of Golgi Inheritance Interleukin-34-mediated Signaling Pathway Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Regulation Of Lipid Biosynthetic Process Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Regulation Of Steroid Biosynthetic Process Bergmann Glial Cell Differentiation Lipid Droplet Cellular Response To Tumor Necrosis Factor Cellular Response To Cold Regulation Of Lipid Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Steroid Metabolic Process Lipid Binding MAP Kinase Activity Regulation Of Golgi Organization Pseudopodium Response To Tumor Necrosis Factor Regulation Of Early Endosome To Late Endosome Transport Schwann Cell Development Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of Neuroinflammatory Response Animal Organ Formation Positive Regulation Of Cholesterol Biosynthetic Process Face Development Stress-activated MAPK Cascade ERBB2 Signaling Pathway Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Macrophage Migration Neural Crest Cell Development Lung Morphogenesis Positive Regulation Of Inflammatory Response Positive Regulation Of Cholesterol Metabolic Process Regulation Of Macrophage Chemotaxis Thyroid Gland Development Regulation Of Cholesterol Biosynthetic Process Astrocyte Differentiation Insulin-like Growth Factor Receptor Signaling Pathway Stem Cell Development Regulation Of Stress-activated MAPK Cascade
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