PLIN1 and LIPE

Number of citations of the paper that reports this interaction (PMID 17189257)
70

Data Source:
BioGRID (fluorescent resonance energy transfer, protein complementation assay)

		PLIN1	LIPE
Gene Name		perilipin 1	lipase, hormone-sensitive
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Lipid Particle Cytosol	Lipid Particle Cytosol Caveola
	Molecular Function	Lipid Binding	Triglyceride Lipase Activity Protein Binding Protein Kinase Binding Hormone-sensitive Lipase Activity
	Biological Process	Lipid Metabolic Process Triglyceride Catabolic Process Small Molecule Metabolic Process	Protein Phosphorylation Cholesterol Metabolic Process Lipid Catabolic Process Triglyceride Catabolic Process Long-chain Fatty Acid Catabolic Process Small Molecule Metabolic Process Diacylglycerol Catabolic Process
Pathways		Metabolism of lipids and lipoproteins Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis Transcriptional regulation of white adipocyte differentiation Lipid digestion, mobilization, and transport	Metabolism of lipids and lipoproteins Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis Lipid digestion, mobilization, and transport
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: ABHD5 LIPE PRKACA	8 interactors: FABP4 KATNA1 MAPK1 MAPK3 NSFL1C PLIN1 PRKACA STAR
Entrez ID		5346	3991
HPRD ID		01364	01062
Ensembl ID		ENSG00000166819	ENSG00000079435
Uniprot IDs		O60240	Q05469
PDB IDs
Enriched GO Terms of Interacting Partners?		Triglyceride Catabolic Process Acylglycerol Catabolic Process Triglyceride Metabolic Process Neutral Lipid Metabolic Process Cellular Lipid Catabolic Process Lipid Catabolic Process Glycerolipid Metabolic Process Positive Regulation Of Lipase Activity Cellular Lipid Metabolic Process Positive Regulation Of Dense Core Granule Biogenesis Lipid Metabolic Process Histone H3-T6 Phosphorylation Diacylglycerol Catabolic Process Catabolic Process Fatty Acid Metabolic Process Negative Regulation Of Sequestering Of Triglyceride Peptidyl-serine Autophosphorylation Long-chain Fatty Acid Catabolic Process Positive Regulation Of Triglyceride Catabolic Process Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Parathyroid Hormone Stimulus Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Small Molecule Metabolic Process Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Tight Junction Assembly Negative Regulation Of Glucose Import Positive Regulation Of Macrophage Differentiation Positive Regulation Of Lipoprotein Lipase Activity Cell Communication By Electrical Coupling Involved In Cardiac Conduction Response To Parathyroid Hormone Calcium-mediated Signaling Using Intracellular Calcium Source Desmosome Organization Positive Regulation Of Protein Export From Nucleus Monocarboxylic Acid Metabolic Process Cell Communication By Electrical Coupling Phosphate-containing Compound Metabolic Process Activation Of Protein Kinase A Activity Regulation Of Platelet Aggregation Negative Regulation Of Lipid Storage Negative Regulation Of Glucose Transport Sperm Capacitation Diacylglycerol Metabolic Process Cellular Response To Epinephrine Stimulus Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Induction Of Positive Chemotaxis Positive Regulation Of Cardiac Muscle Hypertrophy Response To Epinephrine Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Lipopolysaccharide-mediated Signaling Pathway	Triglyceride Catabolic Process Cellular Response To Growth Hormone Stimulus Acylglycerol Catabolic Process Response To Growth Hormone Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Golgi Inheritance Caveolin-mediated Endocytosis Cellular Response To Peptide Hormone Stimulus Regulation Of Golgi Organization Cellular Response To Peptide Triglyceride Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Neutral Lipid Metabolic Process Regulation Of Early Endosome To Late Endosome Transport Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Cellular Response To Epinephrine Stimulus Cellular Lipid Catabolic Process Cellular Response To Lipopolysaccharide Response To Epinephrine Cellular Response To Molecule Of Bacterial Origin Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Growth Factor Stimulus Cellular Response To Hormone Stimulus JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Growth Factor Platelet Activation Growth Hormone Receptor Signaling Pathway Cellular Response To Catecholamine Stimulus Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Response To Epidermal Growth Factor Regulation Of Cellular Response To Heat Neurotrophin Signaling Pathway Response To Cytokine Regulation Of Protein Kinase Activity Lipid Catabolic Process Lipopolysaccharide-mediated Signaling Pathway Regulation Of Kinase Activity Activation Of Protein Kinase Activity Innate Immune Response Response To Organonitrogen Compound Response To Insulin Regulation Of MAP Kinase Activity Peptidyl-threonine Phosphorylation Response To Exogenous DsRNA
Tagcloud ?		3t3l1 adipogenesis canonical dickkopf disrupted dkk1 droplet droplets ebps fewer fzds k146q lef1 mutants ncor ncordeltaid perilipin ppargamma ppargamma2 preadiocytes preadipocyte preadipocytes recruit rescued sumoylation tr tralpha trbeta wnt	abhd5 agpat2 anomaly atgl cgi ctgm dgat1 diverge enteropathy gk glycerol gpd1 hsl ichthyosis inborn jordan lipodystrophy loosing lpin1 lpin2 majeed nlsd perilipin pnpla2 pseudohypertriglyceridemia rhabdomyolysis steatosis tgs vacuolated
Tagcloud (Difference) ?		3t3l1 adipogenesis canonical dickkopf disrupted dkk1 droplet droplets ebps fewer fzds k146q lef1 mutants ncor ncordeltaid ppargamma ppargamma2 preadiocytes preadipocyte preadipocytes recruit rescued sumoylation tr tralpha trbeta wnt	abhd5 agpat2 anomaly atgl cgi ctgm dgat1 diverge enteropathy gk glycerol gpd1 hsl ichthyosis inborn jordan lipodystrophy loosing lpin1 lpin2 majeed nlsd pnpla2 pseudohypertriglyceridemia rhabdomyolysis steatosis tgs vacuolated
Tagcloud (Intersection) ?		perilipin