BBS4 and ZIC1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		BBS4	ZIC1
Description		Bardet-Biedl syndrome 4	Zic family zinc finger 1
Image			No pdb structure
GO Annotations	Cellular Component	Pericentriolar Material Photoreceptor Outer Segment Photoreceptor Inner Segment Nucleus Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Plasma Membrane Cilium Membrane Motile Cilium Photoreceptor Connecting Cilium Centriolar Satellite BBSome Ciliary Transition Zone Ciliary Basal Body Cell Projection Ciliary Membrane Non-motile Cilium	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity Dynactin Binding Alpha-tubulin Binding Beta-tubulin Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cytokinesis Neuron Migration Leukocyte Homeostasis B Cell Homeostasis Neural Tube Closure Retina Homeostasis Heart Looping Lymphocyte Homeostasis Myeloid Cell Homeostasis Negative Regulation Of Systemic Arterial Blood Pressure Centrosome Cycle Spermatid Development Sensory Perception Visual Perception Sensory Perception Of Smell Intracellular Protein Localization Gene Expression Negative Regulation Of Gene Expression Protein Transport Wnt Signaling Pathway Dendrite Development Regulation Of Lipid Metabolic Process Ventricular System Development Striatum Development Hippocampus Development Cerebral Cortex Development Cell Projection Organization Adult Behavior Negative Regulation Of Actin Filament Polymerization Melanosome Transport Regulation Of Cytokinesis Leptin-mediated Signaling Pathway Protein Localization To Organelle Erythrocyte Homeostasis Microtubule Anchoring At Centrosome Social Behavior Photoreceptor Cell Outer Segment Organization Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Positive Regulation Of Multicellular Organism Growth Response To Leptin Fat Cell Differentiation Photoreceptor Cell Maintenance Positive Regulation Of Cilium Assembly Retinal Rod Cell Development Brain Morphogenesis Homeostasis Of Number Of Cells Sensory Processing Maintenance Of Protein Location In Nucleus Regulation Of Stress Fiber Assembly Cilium Assembly Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Face Development Adipose Tissue Development Fat Pad Development Protein Localization To Cilium Protein Localization To Centrosome Sperm Flagellum Assembly Regulation Of Non-motile Cilium Assembly Protein Localization To Photoreceptor Outer Segment Non-motile Cilium Assembly	Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Nervous System Development Central Nervous System Development Brain Development Adult Walking Behavior Regulation Of Smoothened Signaling Pathway Gene Expression Spinal Cord Development Hippocampus Development Olfactory Bulb Development Cell Differentiation Forebrain Development Positive Regulation Of Protein Import Into Nucleus Inner Ear Morphogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Maintenance Of Cell Number
Pathways		BBSome-mediated cargo-targeting to cilium	Specification of the neural plate border Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs
Diseases		Bardet-Biedl syndrome (BBS)
GWAS		Body mass index ( 28448500 29273807) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Mild obesity-related type 2 diabetes ( 34737425) Theory of mind score in adolescence (Emotional Triangles Task) ( 29472613) Triglycerides ( 30275531) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Adult body size ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chin dimples ( 27182965) Cortical surface area (MOSTest) ( 32665545) Daytime sleep phenotypes ( 27126917) Monobrow ( 27182965) Multiple sclerosis ( 19010793) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		23 interacting genes: ACTB BHMT CALCA CATSPERT DCTN1 EEF1A1 EIF3A EPAS1 EXOC7 FHOD1 HSCB KRT18 MYOG OAS1 PAX2 PCM1 RARA RARG REL SPIRE1 TOM1 TOM1L2 ZIC1	71 interacting genes: ABHD11 ANKRD10 ARID5A ATP23 BBS4 CDPF1 CFAP68 CRX CYSRT1 DAPL1 EEF1AKMT3 FAM168B FOXH1 GLI1 GLI2 GLI3 INTS11 KLHL26 KRT31 KRT34 KRTAP10-8 KRTAP11-1 KRTAP12-1 KRTAP13-2 KRTAP15-1 KRTAP19-1 KRTAP19-2 KRTAP19-5 KRTAP19-7 KRTAP21-2 KRTAP22-1 KRTAP3-2 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP8-1 LITAF MAGED1 METTL27 MGAT5B NFKBID OIP5 OXER1 PATZ1 PEF1 PLAAT1 PLSCR3 RBPMS REL RFC2 RNF144B RUSC1 SMAD4 SMUG1 SPAG8 SPATS1 SUFU TBX19 TEPSIN TLE5 TRAF1 TRIP6 TSC1 UBE2I UFSP1 WWOX YPEL3 ZNF34 ZNF474 ZNF620
Entrez ID		585	7545
HPRD ID		08982	02718
Ensembl ID		ENSG00000140463	ENSG00000152977
Uniprot IDs		A0A0S2Z3A9 B4DQR5 Q96RK4	Q15915
PDB IDs		6XT9
Enriched GO Terms of Interacting Partners?		Nucleus Localization Nuclear Migration Trachea Cartilage Development Glandular Epithelial Cell Development Centriolar Satellite DNA-binding Transcription Factor Activity Microtubule Anchoring At Centrosome Embryonic Organ Development Growth Plate Cartilage Development Positive Regulation Of Metabolic Process Cytoplasm Regulation Of Cell Development Positive Regulation Of Macromolecule Biosynthetic Process Cytosol Response To Peptide Vesicle-mediated Transport Response To Cytokine Microtubule Anchoring At Microtubule Organizing Center Surfactant Homeostasis Cis-regulatory Region Sequence-specific DNA Binding Tube Closure Camera-type Eye Development Cellular Response To Retinoic Acid Neural Tube Closure Columnar/cuboidal Epithelial Cell Development Embryonic Camera-type Eye Development Nucleoplasm Cartilage Development Involved In Endochondral Bone Morphogenesis Positive Regulation Of Biosynthetic Process Microtubule Organizing Center Positive Regulation Of Cell Development Positive Regulation Of Macromolecule Metabolic Process Transcription Regulator Complex Positive Regulation Of Transcription By RNA Polymerase II Response To Retinoic Acid Retinoic Acid Receptor Signaling Pathway Face Development Microtubule Anchoring Positive Regulation Of Nucleobase-containing Compound Metabolic Process Organelle Localization Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Establishment Of Organelle Localization Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Eye Development Protein-containing Complex Tube Formation Negative Regulation Of Cartilage Development Chromatin	Intermediate Filament GLI-SUFU Complex Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Cytosol Keratin Filament Spinal Cord Dorsal/ventral Patterning Protein Binding Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Ciliary Base Ciliary Tip Ventral Midline Development Activin Responsive Factor Complex Morphogenesis Of An Epithelium Hindgut Morphogenesis Dorsal/ventral Pattern Formation Cerebellar Cortex Morphogenesis Proximal/distal Pattern Formation Osteoblast Differentiation Tube Morphogenesis Pituitary Gland Development Tissue Morphogenesis Smoothened Signaling Pathway Negative Regulation Of Wnt Signaling Pathway
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