BBS4 and OAS1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		BBS4	OAS1
Description		Bardet-Biedl syndrome 4	2'-5'-oligoadenylate synthetase 1
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GO Annotations	Cellular Component	Pericentriolar Material Photoreceptor Outer Segment Photoreceptor Inner Segment Nucleus Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Plasma Membrane Cilium Membrane Motile Cilium Photoreceptor Connecting Cilium Centriolar Satellite BBSome Ciliary Transition Zone Ciliary Basal Body Cell Projection Ciliary Membrane Non-motile Cilium	Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Ribosome Membrane
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity Dynactin Binding Alpha-tubulin Binding Beta-tubulin Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Nucleotide Binding 2'-5'-oligoadenylate Synthetase Activity RNA Binding Double-stranded RNA Binding Protein Binding ATP Binding Transferase Activity Nucleotidyltransferase Activity Metal Ion Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cytokinesis Neuron Migration Leukocyte Homeostasis B Cell Homeostasis Neural Tube Closure Retina Homeostasis Heart Looping Lymphocyte Homeostasis Myeloid Cell Homeostasis Negative Regulation Of Systemic Arterial Blood Pressure Centrosome Cycle Spermatid Development Sensory Perception Visual Perception Sensory Perception Of Smell Intracellular Protein Localization Gene Expression Negative Regulation Of Gene Expression Protein Transport Wnt Signaling Pathway Dendrite Development Regulation Of Lipid Metabolic Process Ventricular System Development Striatum Development Hippocampus Development Cerebral Cortex Development Cell Projection Organization Adult Behavior Negative Regulation Of Actin Filament Polymerization Melanosome Transport Regulation Of Cytokinesis Leptin-mediated Signaling Pathway Protein Localization To Organelle Erythrocyte Homeostasis Microtubule Anchoring At Centrosome Social Behavior Photoreceptor Cell Outer Segment Organization Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Positive Regulation Of Multicellular Organism Growth Response To Leptin Fat Cell Differentiation Photoreceptor Cell Maintenance Positive Regulation Of Cilium Assembly Retinal Rod Cell Development Brain Morphogenesis Homeostasis Of Number Of Cells Sensory Processing Maintenance Of Protein Location In Nucleus Regulation Of Stress Fiber Assembly Cilium Assembly Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Face Development Adipose Tissue Development Fat Pad Development Protein Localization To Cilium Protein Localization To Centrosome Sperm Flagellum Assembly Regulation Of Non-motile Cilium Assembly Protein Localization To Photoreceptor Outer Segment Non-motile Cilium Assembly	Immune System Process Glucose Metabolic Process Response To Virus Positive Regulation Of Interferon-beta Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cellular Response To Interferon-alpha Cellular Response To Interferon-beta Glucose Homeostasis Defense Response To Bacterium Surfactant Homeostasis Negative Regulation Of Viral Genome Replication Innate Immune Response Protein Complex Oligomerization Defense Response To Virus Type I Interferon-mediated Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Ribonuclease Activity Interleukin-27-mediated Signaling Pathway Cellular Response To Exogenous DsRNA Positive Regulation Of Monocyte Chemotactic Protein-1 Production Negative Regulation Of IP-10 Production Defense Response To Other Organism Cellular Response To Virus Antiviral Innate Immune Response Positive Regulation Of Cellular Respiration Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways		BBSome-mediated cargo-targeting to cilium	Interferon gamma signaling OAS antiviral response Interferon alpha/beta signaling
Drugs			Cysteine-S-acetamide
Diseases		Bardet-Biedl syndrome (BBS)
GWAS		Body mass index ( 28448500 29273807) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Mild obesity-related type 2 diabetes ( 34737425) Theory of mind score in adolescence (Emotional Triangles Task) ( 29472613) Triglycerides ( 30275531) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Blood protein levels ( 30072576) Body mass index ( 26426971) Glycemic traits ( 23575436) Low HDL-cholesterol levels ( 31006500) Response to fenofibrate (adiponectin levels) ( 23149075) Right-sided colonic diverticulosis ( 31089239) Urate levels ( 31578528)
Interacting Genes		23 interacting genes: ACTB BHMT CALCA CATSPERT DCTN1 EEF1A1 EIF3A EPAS1 EXOC7 FHOD1 HSCB KRT18 MYOG OAS1 PAX2 PCM1 RARA RARG REL SPIRE1 TOM1 TOM1L2 ZIC1	11 interacting genes: ACTN1 BBS4 BUD23 COG6 EXOC5 GOLGA2 HOOK2 PRMT6 RPL30 RUFY1 TRIM27
Entrez ID		585	4938
HPRD ID		08982	08879
Ensembl ID		ENSG00000140463	ENSG00000089127
Uniprot IDs		A0A0S2Z3A9 B4DQR5 Q96RK4	A0A6Q8PHR1 A0A7P0T8F9 A0A7P0T9Q4 A0A7P0Z4N8 H0YIB8 P00973
PDB IDs		6XT9	4IG8
Enriched GO Terms of Interacting Partners?		Nucleus Localization Nuclear Migration Trachea Cartilage Development Glandular Epithelial Cell Development Centriolar Satellite DNA-binding Transcription Factor Activity Microtubule Anchoring At Centrosome Embryonic Organ Development Growth Plate Cartilage Development Positive Regulation Of Metabolic Process Cytoplasm Regulation Of Cell Development Positive Regulation Of Macromolecule Biosynthetic Process Cytosol Response To Peptide Vesicle-mediated Transport Response To Cytokine Microtubule Anchoring At Microtubule Organizing Center Surfactant Homeostasis Cis-regulatory Region Sequence-specific DNA Binding Tube Closure Camera-type Eye Development Cellular Response To Retinoic Acid Neural Tube Closure Columnar/cuboidal Epithelial Cell Development Embryonic Camera-type Eye Development Nucleoplasm Cartilage Development Involved In Endochondral Bone Morphogenesis Positive Regulation Of Biosynthetic Process Microtubule Organizing Center Positive Regulation Of Cell Development Positive Regulation Of Macromolecule Metabolic Process Transcription Regulator Complex Positive Regulation Of Transcription By RNA Polymerase II Response To Retinoic Acid Retinoic Acid Receptor Signaling Pathway Face Development Microtubule Anchoring Positive Regulation Of Nucleobase-containing Compound Metabolic Process Organelle Localization Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Establishment Of Organelle Localization Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Eye Development Protein-containing Complex Tube Formation Negative Regulation Of Cartilage Development Chromatin	Protein Transport Golgi Vesicle Transport Vesicle-mediated Transport Establishment Of Protein Localization Organelle Organization Intracellular Protein Localization Centrosome Cycle Non-motile Cilium Assembly Endosomal Transport Histone H2AR3 Methyltransferase Activity Mitotic Cytokinesis Platelet Morphogenesis Structural Constituent Of Postsynapse Cytoskeleton-dependent Cytokinesis Microtubule Organizing Center Organization Establishment Of Localization In Cell Cellular Localization Negative Regulation Of Catabolic Process Retrograde Transport, Endosome To Golgi Histone H3R2 Methyltransferase Activity Histone Arginine N-methyltransferase Activity RRNA (guanine) Methyltransferase Activity RRNA (guanine-N7)-methylation Negative Regulation Of Autophagy Cytoskeleton Organization Microtubule Cytoskeleton Organization Sensory Processing Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Positive Regulation Of Protein Glycosylation Golgi Organization Identical Protein Binding Supramolecular Fiber Organization Cytosolic Transport FHF Complex Protein-arginine Omega-N Monomethyltransferase Activity Histone H4R3 Methyltransferase Activity
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