PCM1 and DPYSL2

		PCM1	DPYSL2
Description		pericentriolar material 1	dihydropyrimidinase like 2
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GO Annotations	Cellular Component	Pericentriolar Material Nucleoplasm Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Cilium Microtubule Cytoskeleton Membrane Nuclear Membrane Protein-containing Complex Centriolar Satellite Ciliary Transition Zone Ciliary Basal Body Cell Projection Apical Part Of Cell Non-motile Cilium	Cytoplasm Cytosol Cytoskeleton Microtubule Plasma Membrane Cilium Microtubule Cytoskeleton Membrane Extracellular Exosome Mitotic Spindle Plasma Membrane Bounded Cell Projection
	Molecular Function	Protein Binding Identical Protein Binding Molecular Adaptor Activity	Dihydropyrimidinase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides Identical Protein Binding
	Biological Process	Neuron Migration Centrosome Cycle Interkinetic Nuclear Migration Cell Projection Organization Cytoplasmic Microtubule Organization Protein Localization To Organelle Microtubule Anchoring Microtubule Anchoring At Centrosome Social Behavior Intraciliary Transport Involved In Cilium Assembly Negative Regulation Of Neurogenesis Cilium Assembly Regulation Of Protein Complex Stability Protein Localization To Centrosome Positive Regulation Of Intracellular Protein Transport Neuronal Stem Cell Population Maintenance Protein-containing Complex Localization To Centriolar Satellite Non-motile Cilium Assembly	Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleobase Catabolic Process Endocytosis Cytoskeleton Organization Signal Transduction Nervous System Development Cell Differentiation
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	CRMPs in Sema3A signaling Recycling pathway of L1
Drugs			Artenimol
Diseases
GWAS		Atrial fibrillation ( 28416818) Economic and political preferences ( 22566634) Heel bone mineral density x serum urate levels interaction ( 34046847) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Triglyceride levels ( 32203549) Waist-hip ratio ( 30108283) Weight ( 28552196)	Barrett's esophagus or Esophageal adenocarcinoma ( 32918910) Barrett's esophagus or esophageal adenocarcinoma x sex interaction (1df test) ( 32918910) Barrett's esophagus or esophageal adenocarcinoma x sex interaction (2df test) ( 32918910) Bitter alcoholic beverage consumption ( 31046077) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 30224653) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858)
Interacting Genes		57 interacting genes: ABI1 ABI2 AKAP9 ALG13 APP BACE2 BBS4 BICD2 CASK CCHCR1 CDC42 CDK1 CEBPA CEP72 CYTH4 DDIT3 DDX23 DENND1A DYNLL1 E2F4 ECPAS EPS8 EXOC8 FAM81A FXR2 GABARAP GOLGA2 GRN HAP1 ING5 INTS4 KAT5 KLC1 KLC4 KRT15 KRT19 KRT24 LARP4 LSM2 MCRS1 MORF4L1 NDUFA9 PCNT PPIE PRC1 PRKCI PRPF6 RALBP1 RBM11 RBM5 RINT1 RPA2 TFIP11 TTC8 VPS26C WASHC3 ZNF830	18 interacting genes: AP2A1 CDC42 CRMP1 DISC1 DPYSL5 DSCAM DSCR9 EXOSC7 GORASP2 GSK3B LEF1 LUC7L NUMB PLD2 ROCK1 TNIK TUBB UBE2I
Entrez ID		5108	1808
HPRD ID		02624	03914
Ensembl ID		ENSG00000078674	ENSG00000092964
Uniprot IDs		A0A4W8VX11 A0A5H1ZRS1 A2RUU9 B9EIS5 E9PGW9 Q15154	A0A1C7CYX9 Q16555 Q59GB4
PDB IDs		6HYL 6HYM 7Q46	2GSE 2VM8 5LXX 5MKV 5MLE 5X1A 5X1C 5X1D 5YZ5 5YZA 5YZB 6JV9 6JVB 7X68 8DNM
Enriched GO Terms of Interacting Partners?		Cytoskeleton Organelle Organization Cytoskeleton Organization Microtubule-based Process Centrosome Supramolecular Fiber Organization Positive Regulation Of Organelle Organization Cytosol Spliceosomal Complex Microtubule Cytoskeleton Organization Centriolar Satellite Regulation Of Supramolecular Fiber Organization Growth Cone Microtubule Organizing Center Organization Regulation Of Organelle Organization Catalytic Step 2 Spliceosome Cellular Component Assembly Regulation Of Cell Cycle Cellular Response To Stress Microtubule Intracellular Protein Localization Positive Regulation Of Cellular Component Organization Establishment Of Protein Localization CHOP-C/EBP Complex Regulation Of Actin Filament Organization RNA Splicing Cytoplasm Cellular Localization Astrocyte Activation Involved In Immune Response Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Sensory Processing Regulation Of Attachment Of Spindle Microtubules To Kinetochore Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity MRNA Splicing, Via Spliceosome Histone Acetyltransferase Complex Epithelial Cell Differentiation Protein Transport Mitotic DNA Damage Checkpoint Signaling Regulation Of Cytoskeleton Organization RNA Splicing, Via Transesterification Reactions Mitotic DNA Integrity Checkpoint Signaling Positive Regulation Of Protein Metabolic Process Mitotic Spindle Microtubule Nucleation MRNA Processing Golgi Disassembly Nuclear DNA Replication Organelle Disassembly	Glutamatergic Synapse Nervous System Development Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Neuron Projection Development Positive Regulation Of Cell-substrate Adhesion Regulation Of Cell Projection Organization Positive Regulation Of Cell-matrix Adhesion System Development Cell Projection Organization Positive Regulation Of Cell Projection Organization Regulation Of Cell Development Regulation Of Neurogenesis Regulation Of Cell-substrate Adhesion Presynapse Cytoskeleton Organization Regulation Of Nervous System Development Wnt Signaling Pathway Neuron Projection Morphogenesis Regulation Of Cell-matrix Adhesion Cell Projection Morphogenesis Dihydropyrimidinase Activity Regulation Of Synapse Organization Regulation Of Cellular Component Organization Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides Plasma Membrane Bounded Cell Projection Organization Pyrimidine Nucleobase Catabolic Process Positive Regulation Of Locomotion Regulation Of Dendrite Morphogenesis Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds Negative Regulation Of Striated Muscle Tissue Development Negative Regulation Of Muscle Organ Development Negative Regulation Of Muscle Tissue Development Regulation Of Axon Extension Epithelial To Mesenchymal Transition Regulation Of Locomotion Apical Part Of Cell Cytoskeleton Cellular Component Assembly Regulation Of Developmental Process Dendrite Positive Regulation Of Cellular Component Organization Neuron Projection Development Regulation Of Dendrite Development Regulation Of Cell Differentiation Canonical Wnt Signaling Pathway Organelle Organization Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Beta-catenin Binding Pyrimidine Nucleobase Metabolic Process
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