MRPL4 and EXOSC6

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
BioGRID (two hybrid)

		MRPL4	EXOSC6
Gene Name		mitochondrial ribosomal protein L4	exosome component 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrial Inner Membrane Cytosolic Ribosome	Exosome (RNase Complex) Nucleolus Cytosol
	Molecular Function	Structural Constituent Of Ribosome Poly(A) RNA Binding	Exoribonuclease Activity Poly(A) RNA Binding
	Biological Process	Translation Organelle Organization Mitochondrial Translation Mitochondrial Translational Initiation Mitochondrial Translational Elongation Mitochondrial Translational Termination	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RRNA Processing Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay DNA Deamination Isotype Switching
Pathways		Mitochondrial translation Organelle biogenesis and maintenance Mitochondrial translation elongation Mitochondrial translation initiation Mitochondrial translation termination	Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: CLK2 CSNK2A1 DDX24 EIF2B1 EXOSC6 KRTAP4-12 TRIM23 XRN2	35 interactors: C1QBP CHPF DCP1B DIS3 DNAJC30 EIF3I ESRRA EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC7 EXOSC8 EXOSC9 GSE1 LSM1 LSM7 LSM8 MAN2C1 MIF4GD MOCS3 MPP6 MRPL4 MRPS18B NDUFA13 NUDT21 PSMB1 RAB3GAP2 SKIV2L2 SRSF3 TUFM UPF2 XRN1 ZFP36
Entrez ID		51073	118460
HPRD ID		14759	12107
Ensembl ID		ENSG00000105364	ENSG00000223496
Uniprot IDs		Q9BYD3	Q5RKV6
PDB IDs			2NN6
Enriched GO Terms of Interacting Partners?			Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process MRNA Metabolic Process MRNA Catabolic Process RNA Catabolic Process RRNA Metabolic Process Aromatic Compound Catabolic Process Ribosome Biogenesis RRNA Processing Ribonucleoprotein Complex Biogenesis Gene Expression Cellular Macromolecule Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic NcRNA Metabolic Process Nuclear MRNA Surveillance RNA Metabolic Process RNA Surveillance RRNA Catabolic Process Maturation Of 5.8S RRNA RNA Phosphodiester Bond Hydrolysis Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Catabolic Process Nucleobase-containing Compound Metabolic Process Histone MRNA Catabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Processing Cellular Metabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Histone MRNA Metabolic Process MRNA Processing RNA Splicing Metabolic Process RNA 3'-end Processing RNA Splicing, Via Transesterification Reactions RNA Localization DNA Deamination Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Intracellular MRNA Localization Mitochondrial Translational Elongation MRNA 3'-end Processing Mitochondrion Organization Mitochondrial Translation MRNA Splicing, Via Spliceosome Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
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