MRPL4 and EIF2B1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MRPL4	EIF2B1
Gene Name		mitochondrial ribosomal protein L4	eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrial Inner Membrane Cytosolic Ribosome	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex Plasma Membrane Membrane
	Molecular Function	Structural Constituent Of Ribosome Poly(A) RNA Binding	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding GDP Binding Enzyme Regulator Activity S-methyl-5-thioribose-1-phosphate Isomerase Activity
	Biological Process	Translation Organelle Organization Mitochondrial Translation Mitochondrial Translational Initiation Mitochondrial Translational Elongation Mitochondrial Translational Termination	Translation Translational Initiation Regulation Of Translational Initiation Response To Heat Response To Glucose Gene Expression Oligodendrocyte Development L-methionine Biosynthetic Process From Methylthioadenosine Negative Regulation Of Translational Initiation In Response To Stress Response To Peptide Hormone Positive Regulation Of GTPase Activity Cellular Protein Metabolic Process Cellular Response To Stimulus
Pathways		Mitochondrial translation Organelle biogenesis and maintenance Mitochondrial translation elongation Mitochondrial translation initiation Mitochondrial translation termination	Recycling of eIF2:GDP Translation Eukaryotic Translation Initiation Cap-dependent Translation Initiation
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: CLK2 CSNK2A1 DDX24 EIF2B1 EXOSC6 KRTAP4-12 TRIM23 XRN2	14 interactors: ADRA2A ADRA2B ADRA2C ADRB2 ARL4D CREBBP EIF2B2 EIF2B5 EIF2S1 EIF2S2 GORASP2 MRPL4 RD3 WDYHV1
Entrez ID		51073	1967
HPRD ID		14759	09458
Ensembl ID		ENSG00000105364
Uniprot IDs		Q9BYD3	Q14232
PDB IDs			3ECS
Enriched GO Terms of Interacting Partners?			Adrenergic Receptor Signaling Pathway Activation Of MAPK Activity By Adrenergic Receptor Signaling Pathway Epidermal Growth Factor-activated Receptor Transactivation By G-protein Coupled Receptor Signaling Pathway Receptor Transactivation Negative Regulation Of Epinephrine Secretion Negative Regulation Of Norepinephrine Secretion Regulation Of Smooth Muscle Contraction Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Norepinephrine Secretion Negative Regulation Of Smooth Muscle Contraction Translational Initiation Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Muscle Contraction Negative Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of ERBB Signaling Pathway Activation Of Protein Kinase B Activity Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Protein Tyrosine Kinase Activity Regulation Of Muscle Contraction Positive Regulation Of Receptor Activity Response To Temperature Stimulus Regulation Of Vasoconstriction Positive Regulation Of Protein Kinase Activity Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Kinase Activity Negative Regulation Of Hormone Secretion Regulation Of Translational Initiation Positive Regulation Of Catalytic Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Transferase Activity Regulation Of Translational Initiation In Response To Stress Regulation Of ERBB Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Translation Regulation Of Translation In Response To Stress Response To Heat Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Regulation Of Receptor Activity Regulation Of Protein Kinase Activity Regulation Of Cellular Protein Metabolic Process Reproductive Process Regulation Of Kinase Activity Activation Of MAPK Activity Positive Regulation Of Phosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of MAPK Cascade Regulation Of Protein Metabolic Process Negative Regulation Of Secretion By Cell
Tagcloud ?			1223t 3days 4months 584g antenatal ataxia cach cle cree deterioration exome hypomyelination i408t infantile lethargy leukoencephalopathy optic patch poliovirus r195h resembling resides spasticity vanishing vomiting vwm
Tagcloud (Difference) ?			1223t 3days 4months 584g antenatal ataxia cach cle cree deterioration exome hypomyelination i408t infantile lethargy leukoencephalopathy optic patch poliovirus r195h resembling resides spasticity vanishing vomiting vwm
Tagcloud (Intersection) ?