TXNDC11 and TPO

Number of citations of the paper that reports this interaction (PubMedID 15561711)
0

Data Source:
HPRD (in vivo)

		TXNDC11	TPO
Description		thioredoxin domain containing 11	thyroid peroxidase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Extracellular Space Plasma Membrane Cell Surface Membrane
	Molecular Function	Protein Binding	Iodide Peroxidase Activity Peroxidase Activity Calcium Ion Binding Oxidoreductase Activity Heme Binding Metal Ion Binding
	Biological Process		Thyroid Hormone Generation Response To Oxidative Stress Embryonic Hemopoiesis Hormone Biosynthetic Process Hydrogen Peroxide Catabolic Process Cellular Oxidant Detoxification
Pathways		Thyroxine biosynthesis	Thyroxine biosynthesis
Drugs			Carbimazole Dextrothyroxine Propylthiouracil Methimazole Triclosan Resorcinol 2-mercaptobenzothiazole
Diseases			Thyroid dyshormonogenesis; Dyshormogenetic goiter
GWAS		Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Plasma renin activity levels ( 29650764) Red cell distribution width ( 32888494) Rheumatoid arthritis ( 24390342 30423114) Serum alkaline phosphatase levels ( 33547301) Triglyceride levels ( 32203549) Weight ( 28552196)	Autoimmune thyroid disease ( 32581359) Hypothyroidism ( 27182965 30367059) Medication use (thyroid preparations) ( 31015401) Placebo response in major depressive disorder (% change in symptom score) ( 28696415) Thrombin-activatable fibrinolysis inhibitor levels ( 29378355) Thyroid peroxidase antibody levels ( 24586183) Thyroid peroxidase antibody positivity ( 24586183 24722205) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		22 interacting genes: ACAA1 ATXN7 CDKN1A DUOX1 DUOX2 GFI1B HSP90B1 KLHL38 KRT15 KRT18 MKRN3 NOS3 NRIP1 ORC5 RAB2B RACGAP1 RPS19 RPS6KA5 SOCS3 STAT5A TPO ZNF417	2 interacting genes: DUOX1 TXNDC11
Entrez ID		51061	7173
HPRD ID		07125	06000
Ensembl ID		ENSG00000153066	ENSG00000115705
Uniprot IDs		Q6PKC3	P07202 Q502Y3 Q6P534
PDB IDs
Enriched GO Terms of Interacting Partners?		Superoxide-generating NAD(P)H Oxidase Activity Thyroid Hormone Generation Hydrogen Peroxide Catabolic Process Cellular Oxidant Detoxification Thyroid Hormone Metabolic Process Cuticle Development Reactive Oxygen Species Metabolic Process Peroxidase Activity Hydrogen Peroxide Metabolic Process Cytokine-mediated Signaling Pathway Cellular Detoxification Heme Binding Hormone Biosynthetic Process Ovulation Cycle Process Superoxide Metabolic Process Hydrogen Peroxide Biosynthetic Process Scaffold Protein Binding NAD(P)H Oxidase H2O2-forming Activity Erythrocyte Differentiation Ovulation Phenol-containing Compound Metabolic Process Reactive Oxygen Species Biosynthetic Process NADPH Oxidase Complex Superoxide Anion Generation Nuclear Matrix Regulation Of Wound Healing Lipid Storage Response To Purine-containing Compound Acetate CoA-transferase Activity Phenylacetate Catabolic Process NADP Binding Modified Amino Acid Metabolic Process Iodide Peroxidase Activity Ovarian Follicle Rupture Histone H2AS1 Kinase Activity Regulation Of Response To Wounding Protein Kinase Inhibitor Activity Tissue Morphogenesis Catabolic Process Cytosol Cellular Response To Cytokine Stimulus Hormone Metabolic Process	Response To Nitrosative Stress MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Peptidyl-tyrosine Dephosphorylation Protein Tyrosine/threonine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity MAP Kinase Tyrosine Phosphatase Activity Reactive Oxygen Species Biosynthetic Process Thyroid Hormone Generation Thyroid Hormone Metabolic Process NADPH Oxidase Complex NAD(P)H Oxidase H2O2-forming Activity Hydrogen Peroxide Catabolic Process Superoxide-generating NAD(P)H Oxidase Activity Hydrogen Peroxide Biosynthetic Process Cuticle Development Superoxide Anion Generation Peroxidase Activity Hydrogen Peroxide Metabolic Process NADP Binding Hormone Biosynthetic Process Superoxide Metabolic Process
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