TPO and TXNDC11

Number of citations of the paper that reports this interaction (PMID 15561711)
12

Data Source:
HPRD (in vivo)

		TPO	TXNDC11
Gene Name		thyroid peroxidase	thioredoxin domain containing 11
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Mitochondrion Plasma Membrane Integral Component Of Plasma Membrane Cell Surface	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Iodide Peroxidase Activity Peroxidase Activity Calcium Ion Binding Heme Binding	Protein Disulfide Isomerase Activity Protein Binding
	Biological Process	Thyroid Hormone Generation Response To Oxidative Stress Cellular Nitrogen Compound Metabolic Process Embryonic Hemopoiesis Hormone Biosynthetic Process Hydrogen Peroxide Catabolic Process Small Molecule Metabolic Process Oxidation-reduction Process	Protein Folding Response To Endoplasmic Reticulum Stress Cell Redox Homeostasis
Pathways		Amine-derived hormones Thyroxine biosynthesis Metabolism of amino acids and derivatives
Drugs		Carbimazole Dextrothyroxine Propylthiouracil Methimazole
Diseases
GWAS
Protein-Protein Interactions		2 interactors: DUOX1 TXNDC11	17 interactors: ACAA1 ATXN7 CDKN1A DUOX1 DUOX2 GFI1B HSP90B1 KRT15 KRT18 NOS3 ORC5 RACGAP1 RPS19 RPS6KA5 SOCS3 STAT5A TPO
Entrez ID		7173	51061
HPRD ID		06000	07125
Ensembl ID		ENSG00000115705	ENSG00000153066
Uniprot IDs		P07202 Q502Y3 Q6P534	Q6PKC3
PDB IDs
Enriched GO Terms of Interacting Partners?		Cuticle Development Hydrogen Peroxide Biosynthetic Process Superoxide Anion Generation Thyroid Hormone Generation Hydrogen Peroxide Catabolic Process Thyroid Hormone Metabolic Process Hydrogen Peroxide Metabolic Process Superoxide Metabolic Process Hormone Biosynthetic Process Phenol-containing Compound Metabolic Process Reactive Oxygen Species Metabolic Process Cell Redox Homeostasis Response To CAMP	Thyroid Hormone Generation Hydrogen Peroxide Catabolic Process Thyroid Hormone Metabolic Process Cytokine-mediated Signaling Pathway Regulation Of Innate Immune Response Reactive Oxygen Species Metabolic Process Anatomical Structure Development Cuticle Development Cellular Response To Organic Substance Hydrogen Peroxide Metabolic Process Cellular Response To Cytokine Stimulus Developmental Process Immune System Process Response To Cytokine Hormone Biosynthetic Process Positive Regulation Of Innate Immune Response Response To Organonitrogen Compound Response To Organic Substance Regulation Of Immune Response Cellular Modified Amino Acid Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Phenol-containing Compound Metabolic Process Negative Regulation Of Cell Death Multicellular Organismal Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Catabolic Process Growth Hormone Receptor Signaling Pathway System Development Response To Organophosphorus Cellular Response To Growth Hormone Stimulus Regulation Of Immune System Process Response To Stress Response To Purine-containing Compound Hormone Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Response To Growth Hormone Regulation Of Protein Metabolic Process Regulation Of Cell Death Organ Development JAK-STAT Cascade Cell Surface Receptor Signaling Pathway Organelle Organization Histone H2A-S1 Phosphorylation Cytokinesis, Initiation Of Separation Actomyosin Contractile Ring Assembly
Tagcloud ?		125i anaemia blasts count counts deranged equilibrium excess fmol immunoassay inversely irrespective mds megakaryocyte megakaryocytes metabolizes normals operate plasma platelet quite ra raeb refractory smaller sparse syndromes thrombocytopenia thrombopoietin
Tagcloud (Difference) ?		125i anaemia blasts count counts deranged equilibrium excess fmol immunoassay inversely irrespective mds megakaryocyte megakaryocytes metabolizes normals operate plasma platelet quite ra raeb refractory smaller sparse syndromes thrombocytopenia thrombopoietin
Tagcloud (Intersection) ?