TPO and DUOX1

Number of citations of the paper that reports this interaction (PubMedID 15561711)
0

Data Source:
HPRD (in vivo)

		TPO	DUOX1
Description		thyroid peroxidase	dual oxidase 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Cell Surface Membrane	Endoplasmic Reticulum Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Cell Leading Edge NADPH Oxidase Complex
	Molecular Function	Iodide Peroxidase Activity Peroxidase Activity Calcium Ion Binding Oxidoreductase Activity Heme Binding Metal Ion Binding	Peroxidase Activity Calcium Ion Binding Protein Binding NAD(P)H Oxidase H2O2-forming Activity Superoxide-generating NAD(P)H Oxidase Activity Oxidoreductase Activity Heme Binding Metal Ion Binding NADP Binding
	Biological Process	Thyroid Hormone Generation Response To Oxidative Stress Embryonic Hemopoiesis Hormone Biosynthetic Process Hydrogen Peroxide Catabolic Process Cellular Oxidant Detoxification	Thyroid Hormone Generation Defense Response Response To Oxidative Stress Cytokine-mediated Signaling Pathway Cuticle Development Hormone Biosynthetic Process Superoxide Anion Generation Hydrogen Peroxide Catabolic Process Hydrogen Peroxide Biosynthetic Process Response To CAMP Cellular Response To Cytokine Stimulus Reactive Oxygen Species Metabolic Process Positive Regulation Of Wound Healing Cellular Oxidant Detoxification Positive Regulation Of Cell Motility
Pathways		Thyroxine biosynthesis	Thyroxine biosynthesis
Drugs		Carbimazole Dextrothyroxine Propylthiouracil Methimazole Triclosan Resorcinol 2-mercaptobenzothiazole
Diseases		Thyroid dyshormonogenesis; Dyshormogenetic goiter
GWAS		Autoimmune thyroid disease ( 32581359) Hypothyroidism ( 27182965 30367059) Medication use (thyroid preparations) ( 31015401) Placebo response in major depressive disorder (% change in symptom score) ( 28696415) Thrombin-activatable fibrinolysis inhibitor levels ( 29378355) Thyroid peroxidase antibody levels ( 24586183) Thyroid peroxidase antibody positivity ( 24586183 24722205) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		2 interacting genes: DUOX1 TXNDC11	2 interacting genes: TPO TXNDC11
Entrez ID		7173	53905
HPRD ID		06000	08421
Ensembl ID		ENSG00000115705	ENSG00000137857
Uniprot IDs		P07202 Q502Y3 Q6P534	Q9NRD9
PDB IDs			7D3E 7D3F
Enriched GO Terms of Interacting Partners?		Response To Nitrosative Stress MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Peptidyl-tyrosine Dephosphorylation Protein Tyrosine/threonine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity MAP Kinase Tyrosine Phosphatase Activity Reactive Oxygen Species Biosynthetic Process Thyroid Hormone Generation Thyroid Hormone Metabolic Process NADPH Oxidase Complex NAD(P)H Oxidase H2O2-forming Activity Hydrogen Peroxide Catabolic Process Superoxide-generating NAD(P)H Oxidase Activity Hydrogen Peroxide Biosynthetic Process Cuticle Development Superoxide Anion Generation Peroxidase Activity Hydrogen Peroxide Metabolic Process NADP Binding Hormone Biosynthetic Process Superoxide Metabolic Process	Iodide Peroxidase Activity Thyroid Hormone Generation Embryonic Hemopoiesis Thyroid Hormone Metabolic Process Hydrogen Peroxide Catabolic Process Peroxidase Activity Hydrogen Peroxide Metabolic Process Hormone Biosynthetic Process Phenol-containing Compound Metabolic Process Cellular Oxidant Detoxification Reactive Oxygen Species Metabolic Process Cellular Detoxification Heme Binding
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