TPO and DUOX1

Number of citations of the paper that reports this interaction (PMID 15561711)
12

Data Source:
HPRD (in vivo)

		TPO	DUOX1
Gene Name		thyroid peroxidase	dual oxidase 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Mitochondrion Plasma Membrane Integral Component Of Plasma Membrane Cell Surface	Integral Component Of Membrane Apical Plasma Membrane
	Molecular Function	Iodide Peroxidase Activity Peroxidase Activity Calcium Ion Binding Heme Binding	Peroxidase Activity Calcium Ion Binding NAD(P)H Oxidase Activity Heme Binding NADP Binding
	Biological Process	Thyroid Hormone Generation Response To Oxidative Stress Cellular Nitrogen Compound Metabolic Process Embryonic Hemopoiesis Hormone Biosynthetic Process Hydrogen Peroxide Catabolic Process Small Molecule Metabolic Process Oxidation-reduction Process	Thyroid Hormone Generation Response To Oxidative Stress Cytokine-mediated Signaling Pathway Cuticle Development Hormone Biosynthetic Process Superoxide Anion Generation Hydrogen Peroxide Catabolic Process Hydrogen Peroxide Biosynthetic Process Response To CAMP Oxidation-reduction Process
Pathways		Amine-derived hormones Thyroxine biosynthesis Metabolism of amino acids and derivatives
Drugs		Carbimazole Dextrothyroxine Propylthiouracil Methimazole
Diseases
GWAS
Protein-Protein Interactions		2 interactors: DUOX1 TXNDC11	2 interactors: TPO TXNDC11
Entrez ID		7173	53905
HPRD ID		06000	08421
Ensembl ID		ENSG00000115705	ENSG00000137857
Uniprot IDs		P07202 Q502Y3 Q6P534	Q9NRD9
PDB IDs
Enriched GO Terms of Interacting Partners?		Cuticle Development Hydrogen Peroxide Biosynthetic Process Superoxide Anion Generation Thyroid Hormone Generation Hydrogen Peroxide Catabolic Process Thyroid Hormone Metabolic Process Hydrogen Peroxide Metabolic Process Superoxide Metabolic Process Hormone Biosynthetic Process Phenol-containing Compound Metabolic Process Reactive Oxygen Species Metabolic Process Cell Redox Homeostasis Response To CAMP	Thyroid Hormone Generation Hydrogen Peroxide Catabolic Process Thyroid Hormone Metabolic Process Embryonic Hemopoiesis Hydrogen Peroxide Metabolic Process Hormone Biosynthetic Process
Tagcloud ?		125i anaemia blasts count counts deranged equilibrium excess fmol immunoassay inversely irrespective mds megakaryocyte megakaryocytes metabolizes normals operate plasma platelet quite ra raeb refractory smaller sparse syndromes thrombocytopenia thrombopoietin	airway atp avidin biotin cytoskeletal epithelial glutathionylated glutathionylation gsh h292 h2o2 homolog incompletely innate labeling mapk migration nadph oxidase peroxiredoxin precise proteomics redox reversible shrna tagged tracheal transfection untreated
Tagcloud (Difference) ?		125i anaemia blasts count counts deranged equilibrium excess fmol immunoassay inversely irrespective mds megakaryocyte megakaryocytes metabolizes normals operate plasma platelet quite ra raeb refractory smaller sparse syndromes thrombocytopenia thrombopoietin	airway atp avidin biotin cytoskeletal epithelial glutathionylated glutathionylation gsh h292 h2o2 homolog incompletely innate labeling mapk migration nadph oxidase peroxiredoxin precise proteomics redox reversible shrna tagged tracheal transfection untreated
Tagcloud (Intersection) ?