TXNDC11 and DUOX2

Number of citations of the paper that reports this interaction (PubMedID 15561711)
0

Data Source:
HPRD (in vivo)

		TXNDC11	DUOX2
Description		thioredoxin domain containing 11	dual oxidase 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Endoplasmic Reticulum Cytosol Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Cell Leading Edge NADPH Oxidase Complex Apical Part Of Cell Extracellular Exosome Anchoring Junction
	Molecular Function	Protein Binding	Peroxidase Activity Calcium Ion Binding Protein Binding NAD(P)H Oxidase H2O2-forming Activity Superoxide-generating NAD(P)H Oxidase Activity Oxidoreductase Activity Heme Binding Metal Ion Binding
	Biological Process		Thyroid Hormone Generation Defense Response Response To Oxidative Stress Response To Virus Cytokine-mediated Signaling Pathway Cuticle Development Hormone Biosynthetic Process Superoxide Anion Generation Hydrogen Peroxide Catabolic Process Hydrogen Peroxide Biosynthetic Process Response To CAMP Cellular Response To Cytokine Stimulus Positive Regulation Of Wound Healing Cellular Oxidant Detoxification Positive Regulation Of Cell Motility
Pathways		Thyroxine biosynthesis	Thyroxine biosynthesis
Drugs
Diseases			Thyroid dyshormonogenesis; Dyshormogenetic goiter
GWAS		Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Plasma renin activity levels ( 29650764) Red cell distribution width ( 32888494) Rheumatoid arthritis ( 24390342 30423114) Serum alkaline phosphatase levels ( 33547301) Triglyceride levels ( 32203549) Weight ( 28552196)	Iron status biomarkers (ferritin levels) ( 33536631) Iron status biomarkers (iron levels) ( 33536631) Iron status biomarkers (total iron binding capacity) ( 33536631) Iron status biomarkers (transferrin saturation) ( 33536631)
Interacting Genes		22 interacting genes: ACAA1 ATXN7 CDKN1A DUOX1 DUOX2 GFI1B HSP90B1 KLHL38 KRT15 KRT18 MKRN3 NOS3 NRIP1 ORC5 RAB2B RACGAP1 RPS19 RPS6KA5 SOCS3 STAT5A TPO ZNF417	1 interacting genes: TXNDC11
Entrez ID		51061	50506
HPRD ID		07125	05997
Ensembl ID		ENSG00000153066	ENSG00000140279
Uniprot IDs		Q6PKC3	Q9NRD8 X6RAN8
PDB IDs
Enriched GO Terms of Interacting Partners?		Superoxide-generating NAD(P)H Oxidase Activity Thyroid Hormone Generation Hydrogen Peroxide Catabolic Process Cellular Oxidant Detoxification Thyroid Hormone Metabolic Process Cuticle Development Reactive Oxygen Species Metabolic Process Peroxidase Activity Hydrogen Peroxide Metabolic Process Cytokine-mediated Signaling Pathway Cellular Detoxification Heme Binding Hormone Biosynthetic Process Ovulation Cycle Process Superoxide Metabolic Process Hydrogen Peroxide Biosynthetic Process Scaffold Protein Binding NAD(P)H Oxidase H2O2-forming Activity Erythrocyte Differentiation Ovulation Phenol-containing Compound Metabolic Process Reactive Oxygen Species Biosynthetic Process NADPH Oxidase Complex Superoxide Anion Generation Nuclear Matrix Regulation Of Wound Healing Lipid Storage Response To Purine-containing Compound Acetate CoA-transferase Activity Phenylacetate Catabolic Process NADP Binding Modified Amino Acid Metabolic Process Iodide Peroxidase Activity Ovarian Follicle Rupture Histone H2AS1 Kinase Activity Regulation Of Response To Wounding Protein Kinase Inhibitor Activity Tissue Morphogenesis Catabolic Process Cytosol Cellular Response To Cytokine Stimulus Hormone Metabolic Process
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