FOXP3 and STUB1

Number of citations of the paper that reports this interaction (PMID 23973223)
6

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, enzymatic study)

		FOXP3	STUB1
Gene Name		forkhead box P3	STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Protein Complex	Ubiquitin Ligase Complex Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Ubiquitin Conjugating Enzyme Complex Nuclear Inclusion Body Intermediate Filament Cytoskeleton Extracellular Vesicular Exosome
	Molecular Function	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Histone Acetyltransferase Binding Protein Homodimerization Activity Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding NF-kappaB Binding NFAT Protein Binding	G-protein Coupled Receptor Binding Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity Enzyme Binding Kinase Binding Hsp70 Protein Binding Protein Binding, Bridging TPR Domain Binding Ubiquitin Protein Ligase Binding Ubiquitin-ubiquitin Ligase Activity Protein Homodimerization Activity SMAD Binding Misfolded Protein Binding Hsp90 Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter B Cell Homeostasis Cytokine Production Myeloid Cell Homeostasis CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation T Cell Mediated Immunity Tolerance Induction To Self Antigen Positive Regulation Of T Cell Anergy Negative Regulation Of Chronic Inflammatory Response Negative Regulation Of T Cell Cytokine Production Positive Regulation Of Peripheral T Cell Tolerance Induction Chromatin Remodeling Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Proliferation Response To Virus Negative Regulation Of Histone Deacetylation Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Interleukin-4 Production Negative Regulation Of Interleukin-5 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-4 Production Negative Regulation Of CREB Transcription Factor Activity Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Positive Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of Histone Acetylation Negative Regulation Of Histone Acetylation Negative Regulation Of Cytokine Biosynthetic Process T Cell Activation Negative Regulation Of T Cell Proliferation T Cell Homeostasis Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Interferon-gamma Biosynthetic Process Negative Regulation Of Interleukin-2 Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Activated T Cell Proliferation Negative Regulation Of Isotype Switching To IgE Isotypes Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Cytokine Secretion Negative Regulation Of Immune Response T Cell Receptor Signaling Pathway	Protein Polyubiquitination DNA Repair Ubiquitin-dependent Protein Catabolic Process Misfolded Or Incompletely Synthesized Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Ubiquitination Regulation Of Glucocorticoid Metabolic Process Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Protein Maturation Protein Autoubiquitination Protein K63-linked Ubiquitination Cellular Response To Misfolded Protein Positive Regulation Of Chaperone-mediated Protein Complex Assembly
Pathways			Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Antigen processing: Ubiquitination & Proteasome degradation Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Downregulation of TGF-beta receptor signaling TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by ERBB2 Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Class I MHC mediated antigen processing & presentation SMAD4 MH2 Domain Mutants in Cancer Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: EP300 IKZF4 KAT8 NFAT5 NFATC2 PRR20A RBPMS RUNX1 STUB1	92 interactors: ABL1 ACD AHR AR ATCAY ATXN3 BAG1 BAG5 BCR BMPR1B CCL28 CTBP2 CYP2E1 CYP3A4 DAXX DNAJB1 DYX1C1 EIF5A ERBB2 ERN1 ESR1 FBXO2 FBXO27 FOXP3 GHR GPR37 GUCY1A2 GUCY1A3 HIF1A HSF1 HSP90AA1 HSPA1A HSPA1B HSPA4 HSPA8 IRF1 JOSD1 JOSD2 KHDRBS1 KIAA1524 MAP3K11 MAP3K2 MAPT MCF2 MITF MPP1 MST1R MYOCD NOS1 NQO1 OLFM3 PARK2 PFN1 POLB POT1 PRKCZ PSMA3 PSMD4 RAF1 RUNX1 RUNX2 RUSC1 S100A2 S100P SIRT6 SMAD1 SMAD2 SMAD3 SMAD4 SMG5 SMURF1 SRC TAL1 TERF1 TGFBR1 TINF2 TRAF6 TXN2 UBB UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2L3 UBE2N UBE2Q1 UBE2V1 UBE2W VCP XIAP
Entrez ID		50943	10273
HPRD ID		02242	06232
Ensembl ID		ENSG00000049768	ENSG00000103266
Uniprot IDs		Q9BZS1	Q9UNE7
PDB IDs		3QRF
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Biosynthetic Process Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Histone H4 Acetylation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone H2B Acetylation Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein Negative Regulation Of Gene Expression ER-nucleus Signaling Pathway Negative Regulation Of Biosynthetic Process Cellular Response To Topologically Incorrect Protein Histone Acetylation Positive Regulation Of Chaperone-mediated Protein Complex Assembly Positive Regulation Of Progesterone Secretion Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Response To Unfolded Protein Protein Acetylation Regulation Of Signal Transduction Cytokine Production N-terminal Peptidyl-lysine Acetylation Regulation Of Progesterone Secretion	Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Response To Organic Substance Regulation Of Metabolic Process Cellular Response To Stimulus Protein Polyubiquitination Response To Stress Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Protein Ubiquitination Regulation Of Cell Proliferation Regulation Of Protein Metabolic Process Response To Stimulus Cellular Metabolic Process Regulation Of Signal Transduction Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Organic Substance Positive Regulation Of Protein Modification Process Positive Regulation Of Gene Expression Cellular Response To Stress Regulation Of Signaling Positive Regulation Of Transferase Activity Regulation Of Catalytic Activity Cellular Response To Growth Factor Stimulus Positive Regulation Of Catalytic Activity Regulation Of Cell Death Protein Ubiquitination Response To Growth Factor Regulation Of Cellular Component Organization Protein Modification By Small Protein Conjugation Cellular Protein Metabolic Process Regulation Of Cellular Process Cell Communication Positive Regulation Of Transcription, DNA-templated Cellular Protein Modification Process Regulation Of Apoptotic Process Regulation Of Immune System Process Signaling Cell Death Death Cellular Nitrogen Compound Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Cell Death Negative Regulation Of Protein Metabolic Process Protein Metabolic Process
Tagcloud ?		17a administrated asthmatic balf bas basophils bsyqf dex eos ethnopharmacological formulae hematoxylin hyperresponsiveness imbalance lym mch methacholine mon ova ovalbumin plex prominently qi rorgammat schiff shen th17 treg yi	atg5 atg7 autophagic autophagosomes autophagy beclin chaperone degradation degraded delta133p53alpha downregulated e3 full identifies isoform knockdown ligase orchestrates passage proliferating replicative replicatively restores reveals senescence senescent sirna turnover unlike
Tagcloud (Difference) ?		17a administrated asthmatic balf bas basophils bsyqf dex eos ethnopharmacological formulae hematoxylin hyperresponsiveness imbalance lym mch methacholine mon ova ovalbumin plex prominently qi rorgammat schiff shen th17 treg yi	atg5 atg7 autophagic autophagosomes autophagy beclin chaperone degradation degraded delta133p53alpha downregulated e3 full identifies isoform knockdown ligase orchestrates passage proliferating replicative replicatively restores reveals senescence senescent sirna turnover unlike
Tagcloud (Intersection) ?