STMN3 and GLP1R

Number of citations of the paper that reports this interaction (PMID 23864651)
0

Data Source:
BioGRID (protein complementation assay, affinity chromatography technology)

		STMN3	GLP1R
Gene Name		stathmin-like 3	glucagon-like peptide 1 receptor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Golgi Apparatus Axon Growth Cone Neuron Projection	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Tubulin Binding Protein Domain Specific Binding	Transmembrane Signaling Receptor Activity Glucagon Receptor Activity
	Biological Process	Microtubule Depolymerization Nervous System Development Regulation Of Microtubule Polymerization Or Depolymerization Cytoplasmic Microtubule Organization Neuron Projection Development Regulation Of Rac GTPase Activity Negative Regulation Of Rac Protein Signal Transduction Regulation Of Cytoskeleton Organization	Energy Reserve Metabolic Process Response To Stress G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Learning Or Memory Regulation Of Heart Contraction CAMP-mediated Signaling Small Molecule Metabolic Process Regulation Of Insulin Secretion Cellular Response To Glucagon Stimulus
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Integration of energy metabolism G alpha (s) signalling events Regulation of insulin secretion Glucagon-type ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs			Glucagon recombinant Exenatide Liraglutide
Diseases
GWAS		Prostate cancer ( 23535732) Ulcerative colitis ( 21297633)
Protein-Protein Interactions		5 interactors: GLP1R NKX3-1 SPCS2 TRPC5 UBQLN1	41 interactors: ACSF3 APH1A ARFRP1 ATP13A1 C14orf166 C18orf32 CALM1 CAND2 CEND1 CFI CYSTM1 ELOVL1 ERP29 GABBR2 GCG GPR37 GPRASP1 HPN IFITM3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 MFSD5 MRPL22 MYL6 NOTCH2NL NRGN NUCKS1 P4HTM PAQR6 PIGG SLC15A4 STMN1 STMN3 STOML2 SUMO1 SVOP SYNGR3 TMEM147 TSPAN13
Entrez ID		50861	2740
HPRD ID		16324	00677
Ensembl ID		ENSG00000197457	ENSG00000112164
Uniprot IDs		B7Z5G4 Q9NZ72	P43220
PDB IDs			3C59 3C5T 3IOL
Enriched GO Terms of Interacting Partners?		Regulation Of Hormone Secretion Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Secretion Cellular Response To Oxygen Levels Positive Regulation Of Androgen Secretion Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Estrogen Receptor Binding Regulation Of Insulin Secretion Regulation Of Cellular Localization Regulation Of Peptide Hormone Secretion Protein Processing Regulation Of Signaling Response To Hypoxia Negative Regulation Of Receptor Binding Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Dorsal Aorta Development Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Regulation Of Protein Secretion Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Signal Peptide Processing Mitotic Cell Cycle Arrest Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Pharyngeal System Development Branching Involved In Prostate Gland Morphogenesis CAMP-mediated Signaling Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Cellular Response To Hormone Stimulus Aorta Development Activation Of Adenylate Cyclase Activity Cyclic-nucleotide-mediated Signaling Regulation Of Protein Transport	Microtubule Depolymerization Positive Regulation Of Peptidyl-threonine Phosphorylation Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Substantia Nigra Development Microtubule Polymerization Or Depolymerization Cerebellar Granular Layer Maturation Positive Regulation Of Cardiolipin Metabolic Process Protein Unfolding Positive Regulation Of Mitochondrial DNA Replication Stress-induced Mitochondrial Fusion Malonate Catabolic Process Molybdate Ion Transport
Tagcloud ?			2a cardiac cardiomyopathies cardioprotective ccaat chaperone chemoattractant chop endoplasmic ex4 exendin fibrosis glucagon gluco grp78 homologous incretin infarction infiltration lipotoxicity mcp1 mhc monocyte reperfusion reticulum sarco serca2a viable
Tagcloud (Difference) ?			2a cardiac cardiomyopathies cardioprotective ccaat chaperone chemoattractant chop endoplasmic ex4 exendin fibrosis glucagon gluco grp78 homologous incretin infarction infiltration lipotoxicity mcp1 mhc monocyte reperfusion reticulum sarco serca2a viable
Tagcloud (Intersection) ?