GRHL2 and LMO4

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		GRHL2	LMO4
Gene Name		grainyhead-like 2 (Drosophila)	LIM domain only 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cell-cell Junction	Transcription Factor Complex
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding	Enhancer Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Factor Binding Zinc Ion Binding
	Biological Process	In Utero Embryonic Development Neural Tube Closure Cardiac Ventricle Morphogenesis Epithelial Cell Morphogenesis Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Cell Adhesion Brain Development Cell Proliferation Neural Tube Development Cell Junction Assembly Multicellular Organism Growth Embryonic Digit Morphogenesis Camera-type Eye Development Regulation Of DNA Methylation Embryonic Cranial Skeleton Morphogenesis Positive Regulation Of Telomerase Activity Face Development Lung Lobe Morphogenesis Lung Epithelial Cell Differentiation Tight Junction Assembly Epithelium Migration	Neural Tube Closure Ventricular Septum Development Transcription From RNA Polymerase II Promoter Ventral Spinal Cord Interneuron Differentiation Spinal Cord Motor Neuron Differentiation Spinal Cord Association Neuron Differentiation Negative Regulation Of Protein Complex Assembly Regulation Of Cell Fate Specification Positive Regulation Of Transcription From RNA Polymerase II Promoter Thymus Development Regulation Of Cell Activation
Pathways
Drugs
Diseases
GWAS			Response to TNF antagonist treatment ( 18615156) White blood cell types ( 21738478)
Protein-Protein Interactions		3 interactors: APP GRHL3 LMO4	53 interactors: AES AMOT AMOTL2 BANP BRCA1 CALCOCO2 CCDC102B CEP170P1 CSNK2B DDB1 DEAF1 ERCC6L GABPB1 GADD45A GOLGA2 GRHL2 GSK3B ITSN1 KANK2 KIAA1958 KIF3B KPNA1 KRT15 KRT31 KRT40 LDB1 LDB2 MERTK MTA1 NFYC NHLH1 NONO PDE4DIP PITPNB PLK1 PPARG RBBP8 RBPMS RPS6KA6 SEC24D SMAD4 SMAD9 TCF21 TCF4 TFIP11 TINAGL1 TNFSF11 TP53BP2 TSEN15 VPS52 ZBTB43 ZNF397 ZNF675
Entrez ID		79977	8543
HPRD ID		10545	09122
Ensembl ID		ENSG00000083307	ENSG00000143013
Uniprot IDs		Q6ISB3	P61968
PDB IDs			2L4Z
Enriched GO Terms of Interacting Partners?		Central Nervous System Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Synaptic Growth At Neuromuscular Junction Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Collateral Sprouting In Absence Of Injury Regulation Of Transcription From RNA Polymerase II Promoter Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Nervous System Development Anatomical Structure Morphogenesis Neuron Remodeling Positive Regulation Of Cellular Metabolic Process Morphogenesis Of An Epithelium Planar Cell Polarity Pathway Involved In Neural Tube Closure Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Spinal Cord Association Neuron Differentiation Wound Healing Eyelid Development In Camera-type Eye Establishment Of Planar Polarity Organ Development Embryonic Morphogenesis Tissue Morphogenesis Cellular Copper Ion Homeostasis Regulation Of Cell Fate Specification Wnt Signaling Pathway, Planar Cell Polarity Pathway Ventral Spinal Cord Interneuron Differentiation RNA Metabolic Process Response To Wounding Copper Ion Homeostasis Suckling Behavior Dorsal Spinal Cord Development Morphogenesis Of A Polarized Epithelium Ectoderm Development Positive Regulation Of Metabolic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cochlea Morphogenesis Gene Expression Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Non-canonical Wnt Signaling Pathway Transcription From RNA Polymerase II Promoter Mating Behavior Regulation Of Cell Fate Commitment Endoplasmic Reticulum Calcium Ion Homeostasis	Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Tissue Development Negative Regulation Of Nucleic Acid-templated Transcription Cellular Nitrogen Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Multicellular Organismal Development Developmental Process Gene Expression Regulation Of Binding Regulation Of Gene Expression Anatomical Structure Development Cellular Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Epithelium Development Negative Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Embryo Development Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Wnt Signaling Pathway Negative Regulation Of Gene Expression Positive Regulation Of Nucleocytoplasmic Transport Embryo Development Ending In Birth Or Egg Hatching Regulation Of Signal Transduction Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Metabolic Process Biosynthetic Process Regulation Of DNA Methylation Cell Cycle Somatic Stem Cell Maintenance Regulation Of Protein Binding Anatomical Structure Morphogenesis
Tagcloud ?		1192t 1445t autosomal consanguinity deafness disclosed dysphagia dystrophy ectodermal enamel exome grainyhead haploinsufficiency homozygous hyperpigmentation hypodontia hypoplasia ile482lys immortalized junctions keratoderma kuwaiti lifelong nail palmoplantar recessive sensorineural transcriptomic tyr398his	arrays attenuated cisplatin cochlea cochlear collectively custom downstream esr1 facilitates immunoblots insights interactomes jak1 machinery mediating modulating modulation nitration otoprotective ototoxicity partners pivotal player relaying stat stat3 trolox wistar
Tagcloud (Difference) ?		1192t 1445t autosomal consanguinity deafness disclosed dysphagia dystrophy ectodermal enamel exome grainyhead haploinsufficiency homozygous hyperpigmentation hypodontia hypoplasia ile482lys immortalized junctions keratoderma kuwaiti lifelong nail palmoplantar recessive sensorineural transcriptomic tyr398his	arrays attenuated cisplatin cochlea cochlear collectively custom downstream esr1 facilitates immunoblots insights interactomes jak1 machinery mediating modulating modulation nitration otoprotective ototoxicity partners pivotal player relaying stat stat3 trolox wistar
Tagcloud (Intersection) ?