GRHL2 and GRHL3

Number of citations of the paper that reports this interaction (PMID 12549979)
16

Data Source:
BioGRID (two hybrid, pull down)
HPRD (two hybrid, in vitro)

		GRHL2	GRHL3
Gene Name		grainyhead-like 2 (Drosophila)	grainyhead-like 3 (Drosophila)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cell-cell Junction	Nucleus
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding
	Biological Process	In Utero Embryonic Development Neural Tube Closure Cardiac Ventricle Morphogenesis Epithelial Cell Morphogenesis Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Cell Adhesion Brain Development Cell Proliferation Neural Tube Development Cell Junction Assembly Multicellular Organism Growth Embryonic Digit Morphogenesis Camera-type Eye Development Regulation Of DNA Methylation Embryonic Cranial Skeleton Morphogenesis Positive Regulation Of Telomerase Activity Face Development Lung Lobe Morphogenesis Lung Epithelial Cell Differentiation Tight Junction Assembly Epithelium Migration	Establishment Of Planar Polarity Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Pattern Specification Process Ectoderm Development Central Nervous System Development Epidermis Development Positive Regulation Of Rho GTPase Activity Regulation Of Actin Cytoskeleton Organization Wound Healing Positive Regulation Of Transcription From RNA Polymerase II Promoter Eyelid Development In Camera-type Eye Cochlea Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure
Pathways
Drugs
Diseases
GWAS			Fasting insulin-related traits (interaction with BMI) ( 22581228)
Protein-Protein Interactions		3 interactors: APP GRHL3 LMO4	5 interactors: GRHL1 GRHL2 PRMT1 PRMT5 PRMT6
Entrez ID		79977	57822
HPRD ID		10545	12210
Ensembl ID		ENSG00000083307	ENSG00000158055
Uniprot IDs		Q6ISB3	Q8TE85
PDB IDs
Enriched GO Terms of Interacting Partners?		Central Nervous System Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Synaptic Growth At Neuromuscular Junction Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Collateral Sprouting In Absence Of Injury Regulation Of Transcription From RNA Polymerase II Promoter Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Nervous System Development Anatomical Structure Morphogenesis Neuron Remodeling Positive Regulation Of Cellular Metabolic Process Morphogenesis Of An Epithelium Planar Cell Polarity Pathway Involved In Neural Tube Closure Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Spinal Cord Association Neuron Differentiation Wound Healing Eyelid Development In Camera-type Eye Establishment Of Planar Polarity Organ Development Embryonic Morphogenesis Tissue Morphogenesis Cellular Copper Ion Homeostasis Regulation Of Cell Fate Specification Wnt Signaling Pathway, Planar Cell Polarity Pathway Ventral Spinal Cord Interneuron Differentiation RNA Metabolic Process Response To Wounding Copper Ion Homeostasis Suckling Behavior Dorsal Spinal Cord Development Morphogenesis Of A Polarized Epithelium Ectoderm Development Positive Regulation Of Metabolic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cochlea Morphogenesis Gene Expression Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Non-canonical Wnt Signaling Pathway Transcription From RNA Polymerase II Promoter Mating Behavior Regulation Of Cell Fate Commitment Endoplasmic Reticulum Calcium Ion Homeostasis	Histone H4-R3 Methylation Peptidyl-arginine N-methylation Histone Arginine Methylation Peptidyl-arginine Methylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Histone Methylation Protein Methylation Histone Modification Methylation Chromatin Modification Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Chromatin Organization Regulation Of Gene Expression Histone H3-R2 Methylation Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Peptidyl-amino Acid Modification Chromosome Organization Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of Telomerase Activity RNA Metabolic Process Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Gene Expression Cellular Macromolecule Biosynthetic Process Lung Lobe Morphogenesis Macromolecule Biosynthetic Process Endothelial Cell Activation Regulation Of Telomerase Activity Regulation Of Metabolic Process Regulation Of Megakaryocyte Differentiation Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of DNA Biosynthetic Process In Utero Embryonic Development Regulation Of DNA Methylation Nucleobase-containing Compound Metabolic Process Regulation Of Hematopoietic Progenitor Cell Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Cell Proliferation Spliceosomal SnRNP Assembly Regulation Of DNA Biosynthetic Process Chordate Embryonic Development Tight Junction Assembly
Tagcloud ?		1192t 1445t autosomal consanguinity deafness disclosed dysphagia dystrophy ectodermal enamel exome grainyhead haploinsufficiency homozygous hyperpigmentation hypodontia hypoplasia ile482lys immortalized junctions keratoderma kuwaiti lifelong nail palmoplantar recessive sensorineural transcriptomic tyr398his	ad advanced augmented chosen circulating clusterin differentially displayed division ed employing enrolling gelsolin htert investigation lumican mismatch plasmatic pms2 presented profile proteomic proteomics repair sall4 stages throughput tnf tumors
Tagcloud (Difference) ?		1192t 1445t autosomal consanguinity deafness disclosed dysphagia dystrophy ectodermal enamel exome grainyhead haploinsufficiency homozygous hyperpigmentation hypodontia hypoplasia ile482lys immortalized junctions keratoderma kuwaiti lifelong nail palmoplantar recessive sensorineural transcriptomic tyr398his	ad advanced augmented chosen circulating clusterin differentially displayed division ed employing enrolling gelsolin htert investigation lumican mismatch plasmatic pms2 presented profile proteomic proteomics repair sall4 stages throughput tnf tumors
Tagcloud (Intersection) ?