GRHL2

Description		grainyhead like transcription factor 2
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cell-cell Junction Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Intronic Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Chromatin DNA Binding Identical Protein Binding Sequence-specific DNA Binding DNA-binding Transcription Factor Binding
	Biological Process	In Utero Embryonic Development Neural Tube Closure Cardiac Ventricle Morphogenesis Epithelial Cell Morphogenesis Regulation Of Transcription By RNA Polymerase II Cell Adhesion Brain Development Epidermis Development Regulation Of Gene Expression Neural Tube Development Keratinocyte Differentiation Respiratory Tube Development Cell Junction Assembly Multicellular Organism Growth Embryonic Digit Morphogenesis Camera-type Eye Development Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Embryonic Cranial Skeleton Morphogenesis Face Development Lung Lobe Morphogenesis Lung Epithelial Cell Differentiation Epithelial Cell Morphogenesis Involved In Placental Branching Anterior Neural Tube Closure Bicellular Tight Junction Assembly Epithelium Migration
Pathways
Drugs
Diseases
GWAS		Bronchopulmonary dysplasia ( 23897914) Chronic hepatitis B infection vs asymptomatic persistence ( 33736632) LDL levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429) Rheumatoid arthritis ( 24390342 30423114)
Interacting Genes		6 interacting genes: APP GRHL3 LMO4 PAX5 PAX6 PIAS2
Entrez ID		79977
HPRD ID		10545
Ensembl ID		ENSG00000083307
Uniprot IDs		B4DL28 Q6ISB3
PDB IDs		5MR7
Enriched GO Terms of Interacting Partners?		Central Nervous System Development Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Nucleobase-containing Compound Biosynthetic Process Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II DNA Binding System Development Negative Regulation Of Macromolecule Biosynthetic Process Chromatin Negative Regulation Of Biosynthetic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Neuron Projection Development Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Embryonic Morphogenesis Cerebral Cortex Development DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Forebrain-midbrain Boundary Formation Chromatin DNA Binding Pancreatic A Cell Development Cell Fate Specification Tube Closure Neural Tube Closure Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process RNA Metabolic Process Acetylcholine Receptor Activator Activity
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