IL21R and JAK1

Number of citations of the paper that reports this interaction (PMID 11418623)
76

Data Source:
HPRD (in vivo)

		IL21R	JAK1
Gene Name		interleukin 21 receptor	Janus kinase 1
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Gene Ontology Annotations	Cellular Component	Integral Component Of Membrane	Nucleus Cytoplasm Cytosol Cytoskeleton Focal Adhesion Endomembrane System Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Interleukin-21 Receptor Activity	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Growth Hormone Receptor Binding Protein Binding ATP Binding Protein Phosphatase Binding CCR5 Chemokine Receptor Binding
	Biological Process	Natural Killer Cell Activation Interleukin-21-mediated Signaling Pathway	Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Migration Cytokine-mediated Signaling Pathway Cell Differentiation Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Interleukin-2-mediated Signaling Pathway Regulation Of Cell Proliferation Innate Immune Response Response To Antibiotic Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway
Pathways			Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Interferon gamma signaling Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor 5 (TLR5) Cascade Interleukin receptor SHC signaling Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome Interleukin-7 signaling SOS-mediated signalling SHC-mediated signalling TRIF-mediated TLR3/TLR4 signaling ERK1 activation ERK1 activation GPCR downstream signaling Signaling by VEGF Toll Like Receptor 3 (TLR3) Cascade Signalling to RAS Downstream signal transduction Interleukin-2 signaling Platelet activation, signaling and aggregation Frs2-mediated activation Axon guidance IRS-mediated signalling Interleukin-6 signaling VEGFA-VEGFR2 Pathway Activated TLR4 signalling VEGFR2 mediated cell proliferation GRB2 events in ERBB2 signaling MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Innate Immune System Signaling by Insulin receptor Insulin receptor signalling cascade ISG15 antiviral mechanism Interferon Signaling Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events SHC-related events Signaling by FGFR ARMS-mediated activation Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Interleukin receptor SHC signaling GPVI-mediated activation cascade Signaling by GPCR FCERI mediated MAPK activation SHC1 events in ERBB2 signaling Signaling by SCF-KIT DAP12 signaling Toll Like Receptor 9 (TLR9) Cascade Signaling by PDGF DAP12 interactions Regulation of IFNA signaling G-protein beta:gamma signalling GRB2 events in EGFR signaling SHC-related events triggered by IGF1R Signaling by ERBB4 Antiviral mechanism by IFN-stimulated genes Signaling by ERBB2 Toll Like Receptor 2 (TLR2) Cascade Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Toll Like Receptor 4 (TLR4) Cascade Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling Interleukin-3, 5 and GM-CSF signaling Signaling by Leptin Signalling to ERKs Prolonged ERK activation events ERK activation Toll Like Receptor 7/8 (TLR7/8) Cascade IGF1R signaling cascade Toll Like Receptor TLR6:TLR2 Cascade IRS-related events triggered by IGF1R MyD88 cascade initiated on plasma membrane ERK activation G beta:gamma signalling through PI3Kgamma Downstream signaling of activated FGFR Interferon alpha/beta signaling Signalling by NGF SOS-mediated signalling MAP kinase activation in TLR cascade SHC-mediated signalling Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Signaling by Overexpressed Wild-Type EGFR in Cancer ERK2 activation SHC1 events in EGFR signaling FRS2-mediated cascade IRS-mediated signalling ERK2 activation Regulation of IFNG signaling
Drugs
Diseases
GWAS		Bone mineral density ( 19874204)
Protein-Protein Interactions		2 interactors: IL21 JAK1	69 interactors: ABL1 BRCA1 BTK CCR1 CCR5 CSF2RB CSF3R CXCR4 EIF2AK2 ELP2 ERBB2 FER FES GHR GNB2L1 GRB2 HIST3H3 IFNAR2 IFNGR1 IGF1R IL10RA IL21R IL2RB IL2RG IL3RA IL4R IL5RA IL6ST IL7R IL9R INPP5D INSR IRS1 IRS2 JAK3 JAKMIP1 MDK OSMR PDGFRA PDGFRB PIK3R1 PLA2G4A PLAUR PLCG2 PRKCZ PRMT5 PTK2B PTPN11 PTPN2 PTPN6 PTPRC RAF1 SH2B2 SHB SOCS1 SOCS3 STAM STAM2 STAT1 STAT2 STAT3 STAT5A STAT6 SYK TEC TNFRSF1A TOP1 TSHR TYK2
Entrez ID		50615	3716
HPRD ID		05649	00992
Ensembl ID			ENSG00000162434
Uniprot IDs		Q9HBE5	P23458
PDB IDs		3TGX	3EYG 3EYH 4E4L 4E4N 4E5W 4EHZ 4EI4 4FK6 4GS0 4I5C 4IVB 4IVC 4IVD 4K6Z 4K77 4L00 4L01
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Natural Killer Cell Cytokine Production Regulation Of Innate Immune Response Interleukin-2-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of Interferon-gamma Biosynthetic Process Positive Regulation Of Interleukin-17 Production Response To Interleukin-2 Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of Natural Killer Cell Differentiation Regulation Of Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Tissue Remodeling Positive Regulation Of Interleukin-10 Production Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Immune Response Regulation Of Immune System Process Peptidyl-tyrosine Autophosphorylation Positive Regulation Of B Cell Proliferation Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Cell Proliferation Positive Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Interferon-gamma Production Regulation Of B Cell Proliferation Response To Antibiotic Positive Regulation Of JAK-STAT Cascade Regulation Of Tissue Remodeling Positive Regulation Of Cytokine Biosynthetic Process Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of B Cell Activation Positive Regulation Of T Cell Proliferation Regulation Of Interferon-gamma Production Regulation Of JAK-STAT Cascade Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Inflammatory Response Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Leukocyte Mediated Cytotoxicity Immune System Process Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Regulation Of Cytokine Biosynthetic Process	Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Cellular Response To Organic Substance Cellular Response To Cytokine Stimulus Response To Organic Substance Response To Cytokine Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Immune Response Defense Response Signaling Cell Communication Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Immune System Process Immune System Process Immune Response Cellular Response To Stimulus Innate Immune Response Response To Stimulus Intracellular Signal Transduction Cellular Response To Organonitrogen Compound JAK-STAT Cascade Growth Hormone Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Regulation Of Cell Proliferation Cellular Response To Growth Hormone Stimulus Response To Stress Cellular Response To Peptide Regulation Of Cell Activation Regulation Of Signal Transduction Response To Organonitrogen Compound Regulation Of Signaling Response To Hormone JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Peptidyl-tyrosine Autophosphorylation Response To Peptide Hormone Peptidyl-tyrosine Phosphorylation Response To Peptide Response To Growth Hormone Cellular Response To Hormone Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Cell Activation Positive Regulation Of Immune System Process Regulation Of Lymphocyte Activation Protein Autophosphorylation Epidermal Growth Factor Receptor Signaling Pathway Immune Response-regulating Signaling Pathway ERBB Signaling Pathway
Tagcloud ?		acquire antigen autoreactive beacon broke ccr7 cd4 cd40 cd40l cd8 cd86 consequently crosslinking dcs draining expanded histocompatibility impairing infiltration islets mhc migrate pancreas reach restored sufficient transferred transferring	2c4 assign b10 b3 b9 cd2 complementation crossed crosses crossing facs gbp guanylate hlas hybrids ifn oas oligoadenylate pairwise permitted responsiveness restore rounds submitted synthetase u3 u4 unresponsive unresponsiveness
Tagcloud (Difference) ?		acquire antigen autoreactive beacon broke ccr7 cd4 cd40 cd40l cd8 cd86 consequently crosslinking dcs draining expanded histocompatibility impairing infiltration islets mhc migrate pancreas reach restored sufficient transferred transferring	2c4 assign b10 b3 b9 cd2 complementation crossed crosses crossing facs gbp guanylate hlas hybrids ifn oas oligoadenylate pairwise permitted responsiveness restore rounds submitted synthetase u3 u4 unresponsive unresponsiveness
Tagcloud (Intersection) ?