PKP4 and PDZD2

Number of citations of the paper that reports this interaction (PubMedID 10896674)
0

Data Source:
HPRD (in vitro, in vivo)

		PKP4	PDZD2
Description		plakophilin 4	PDZ domain containing 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Spindle Pole Cornified Envelope Nucleus Cytoplasm Spindle Cytoskeleton Plasma Membrane Cell-cell Junction Adherens Junction Cytoplasmic Side Of Plasma Membrane Postsynaptic Density Membrane Cell Junction Desmosome Midbody Organelle Cell-cell Contact Zone Perinuclear Region Of Cytoplasm Spindle Midzone Anchoring Junction Mitotic Spindle	Extracellular Region Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Cell-cell Junction Centriolar Satellite
	Molecular Function	Protein Binding Cadherin Binding
	Biological Process	Cell-cell Junction Assembly Cell Adhesion Cell-cell Signaling Regulation Of Cell Adhesion Positive Regulation Of Cytokinesis Regulation Of Rho Protein Signal Transduction Cell-cell Adhesion	Cell Adhesion
Pathways		Keratinization Formation of the cornified envelope RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle
Drugs
Diseases
GWAS		Borderline personality disorder ( 28632202) Obesity-related traits ( 23251661) Restless legs syndrome ( 29029846)	Cerebrospinal fluid t-tau levels in Alzheimer's disease dementia ( 29274321) Chronic obstructive pulmonary disease ( 29394082) Corpus callosum central volume ( 31530798) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 28552196) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intracranial aneurysm ( 29531279) Myocardial infarction ( 26708285) Obesity-related traits ( 23251661) Optic disc size ( 31809533) Renal cell carcinoma ( 23184150) Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels) ( 24528284) Reticulocyte fraction of red cells ( 32888494) Self-reported childhood asthma in adult smokers ( 30373671) Vertical cup-disc ratio ( 31798171 28073927) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Weight ( 34074324) Working memory ( 31598132)
Interacting Genes		20 interacting genes: ATPAF2 CDH1 CDH2 CDH5 DSC3 DSP ERBIN GABARAP GOLGA2 LNX1 LZTS2 MINK1 OGT OSGEP PAXIP1 PDZD2 PGAM1 PSEN1 TRIM23 UBASH3B	5 interacting genes: ADGRB1 CST3 CTNND2 NRXN1 PKP4
Entrez ID		8502	23037
HPRD ID		05043	10142
Ensembl ID		ENSG00000144283	ENSG00000133401
Uniprot IDs		Q99569	O15018
PDB IDs
Enriched GO Terms of Interacting Partners?		Desmosome Cell Junction Cell Adhesion Gamma-catenin Binding Adherens Junction Organization Cell-cell Adhesion Cell-cell Junction Catenin Complex Beta-catenin Binding Anchoring Junction Intracellular Protein Localization Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-cell Adhesion Mediated By Cadherin Cell Junction Organization Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cytoplasm Cadherin Binding Fascia Adherens Cell-cell Junction Organization Adherens Junction Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Desmosome Organization Postsynapse Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Synapse Organization Protein Localization To Cell-cell Junction Smooth Endoplasmic Reticulum Brain Morphogenesis Regulation Of Cellular Localization Cell-cell Junction Assembly Regulation Of Protein Localization To Synapse Regulation Of Protein Localization Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Receptor Localization To Synapse Plasma Membrane Protein Glycosylation Macromolecule Glycosylation Regulation Of Rac Protein Signal Transduction Cell-cell Adhesion Mediator Activity Regulation Of Protein Localization To Nucleus Cytoskeleton Organization Glycosylation Regulation Of Protein Catabolic Process Positive Regulation Of Protein Import Into Nucleus Protein Tyrosine Kinase Binding Cellular Component Assembly Regulation Of Protein Localization To Membrane Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Core Promoter Binding Protein N-acetylglucosaminyltransferase Complex	Cell Projection Morphogenesis Postsynaptic Density Cell Adhesion Neuron Projection Morphogenesis Positive Regulation Of Synapse Assembly Anchoring Junction Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Elastin Catabolic Process Cell-cell Adhesion Cell Junction Organization Positive Regulation Of Presynaptic Active Zone Assembly Positive Regulation Of Presynapse Assembly Positive Regulation Of CAMP-mediated Signaling Protein-containing Complex Assembly Involved In Synapse Maturation Positive Regulation Of Cell Junction Assembly Negative Regulation Of Protein Catabolic Process Negative Regulation Of Blood Vessel Remodeling Protein Complex Involved In Cell-cell Adhesion Guanylate Kinase-associated Protein Clustering Regulation Of Synapse Assembly Positive Regulation Of Neuromuscular Synaptic Transmission Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Transmembrane Signaling Receptor Activity Engulfment Of Apoptotic Cell Cell-cell Junction Cell Junction Plasma Membrane Vesicle Regulation Of Collagen Catabolic Process Adherens Junction Negative Regulation Of Filopodium Assembly Cerebellar Granule Cell Differentiation Postsynaptic Density Protein 95 Clustering Neuronal Signal Transduction NMDA Selective Glutamate Receptor Signaling Pathway NMDA Glutamate Receptor Clustering Gamma-aminobutyric Acid Receptor Clustering Trans-synaptic Protein Complex Gephyrin Clustering Involved In Postsynaptic Density Assembly AMPA Selective Glutamate Receptor Signaling Pathway Neuroligin Family Protein Binding Type 1 Fibroblast Growth Factor Receptor Binding Postsynaptic Membrane Assembly Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Cell Junction Assembly Cell Projection Organization Synapse Organization Cell Junction Assembly Vocal Learning
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