OTC and TOMM20

Number of citations of the paper that reports this interaction (PubMedID 9756929)
0

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		OTC	TOMM20
Description		ornithine transcarbamylase	translocase of outer mitochondrial membrane 20
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix	Mitochondrion Mitochondrial Envelope Mitochondrial Outer Membrane Mitochondrial Outer Membrane Translocase Complex Membrane Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Cell Periphery Sperm Midpiece Migrasome TOM Complex
	Molecular Function	Ornithine Carbamoyltransferase Activity Phospholipid Binding Amino Acid Binding Transferase Activity Carboxyl- Or Carbamoyltransferase Activity Phosphate Ion Binding Identical Protein Binding	Protein Binding Protein Transmembrane Transporter Activity Protein-transporting ATPase Activity Mitochondrion Targeting Sequence Binding Unfolded Protein Binding
	Biological Process	Urea Cycle Liver Development Amino Acid Metabolic Process L-arginine Biosynthetic Process Ornithine Metabolic Process L-ornithine Catabolic Process Midgut Development Amino Acid Biosynthetic Process Response To Xenobiotic Stimulus Response To Zinc Ion Citrulline Biosynthetic Process Response To Nutrient Levels Response To Insulin L-arginine Biosynthetic Process Via Ornithine Monoatomic Anion Homeostasis Response To Biotin Ammonium Homeostasis	Protein Targeting Protein Targeting To Mitochondrion Intracellular Protein Transport Protein Transport TRNA Import Into Mitochondrion Protein Import Into Mitochondrial Matrix Protein Insertion Into Mitochondrial Outer Membrane
Pathways		Mitochondrial protein import Mitochondrial protein import Urea cycle	Mitochondrial protein import PINK1-PRKN Mediated Mitophagy Ub-specific processing proteases
Drugs		Ornithine Citrulline N-(Phosphonoacetyl)-L-Ornithine Norvaline
Diseases		Ornithine transcarbamylase deficiency
GWAS			Apolipoprotein A1 levels ( 32203549) Cholesterol, total ( 20686565) Cobalt levels ( 26025379) Immune reponse to smallpox (secreted IL-2) ( 22610502) LDL cholesterol ( 20686565) LDL cholesterol levels ( 32203549) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		2 interacting genes: CFTR TOMM20	22 interacting genes: AIP APOA1 ATXN1 BAG6 BCL2 CDC73 CEP126 DHFR FBXO7 FEZ1 HAP1 HSD17B10 OTC PINK1 PPHLN1 PTN RECQL4 SNCA TOMM22 UCP1 USP40 VDAC1
Entrez ID		5009	9804
HPRD ID		08947	03507
Ensembl ID		ENSG00000036473	ENSG00000173726
Uniprot IDs		P00480	Q15388
PDB IDs		1C9Y 1EP9 1FVO 1OTH	4APO 7VBY 7VC9 8XVA 9EIH 9EII 9EIJ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Protein-transporting ATPase Activity TRNA Import Into Mitochondrion Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Enamel Mineralization Migrasome Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization TRNA Transport RNA Import Into Mitochondrion TOM Complex Mitochondrion Targeting Sequence Binding Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Amelogenesis Mitochondrial Outer Membrane Translocase Complex ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Protein Insertion Into Mitochondrial Outer Membrane Golgi-associated Vesicle Membrane Cellular Response To Forskolin Mitochondrial Envelope Response To Forskolin Chloride Transmembrane Transporter Activity Sperm Capacitation Bicarbonate Transport Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Protein Import Into Mitochondrial Matrix Water Transport Protein Transmembrane Transporter Activity Multicellular Organismal-level Water Homeostasis Protein Targeting To Mitochondrion Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Ion Transmembrane Transporter Activity Cholesterol Biosynthetic Process 14-3-3 Protein Binding Fluid Transport Transmembrane Transport Transepithelial Transport Establishment Of Protein Localization To Mitochondrial Membrane Protein Insertion Into Mitochondrial Membrane Vesicle Docking Involved In Exocytosis	Regulation Of Protein Stability Mitochondrion Organization Regulation Of Reactive Oxygen Species Metabolic Process Mitochondrion Establishment Of Protein Localization To Mitochondrion Mitochondrial Outer Membrane Neuron Projection Regeneration Regulation Of Autophagy Positive Regulation Of Mitophagy Positive Regulation Of Autophagy Of Mitochondrion Protein Targeting Protein Targeting To Mitochondrion Negative Regulation Of Autophagy Mitochondrial Transport Growth Cone Regulation Of Mitophagy Regulation Of Calcium Ion Transmembrane Transport Negative Regulation Of Metabolic Process Regulation Of Autophagy Of Mitochondrion Negative Regulation Of Neuron Apoptotic Process Establishment Of Protein Localization To Organelle Regulation Of Organelle Transport Along Microtubule Negative Regulation Of Apoptotic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Programmed Cell Death Positive Regulation Of Type 2 Mitophagy Negative Regulation Of Catabolic Process Regulation Of Macroautophagy Negative Regulation Of Autophagosome Assembly Pore Complex Regulation Of Biological Quality Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Calcium Ion Transport Regulation Of Hydrogen Peroxide Metabolic Process Inclusion Body Positive Regulation Of Macroautophagy Regulation Of Neuron Apoptotic Process Axon Regeneration Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Cellular Response To Oxidative Stress Dopamine Transport Regulation Of Oxidative Phosphorylation Mitochondrial Transmembrane Transport Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Mitochondrial Membrane Organization Cellular Localization Regulation Of Dopamine Secretion Establishment Of Localization In Cell
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