OTC

Description		ornithine transcarbamylase
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix
	Molecular Function	Ornithine Carbamoyltransferase Activity Phospholipid Binding Amino Acid Binding Transferase Activity Carboxyl- Or Carbamoyltransferase Activity Phosphate Ion Binding Identical Protein Binding
	Biological Process	Urea Cycle Liver Development Amino Acid Metabolic Process L-arginine Biosynthetic Process Ornithine Metabolic Process L-ornithine Catabolic Process Midgut Development Amino Acid Biosynthetic Process Response To Xenobiotic Stimulus Response To Zinc Ion Citrulline Biosynthetic Process Response To Nutrient Levels Response To Insulin L-arginine Biosynthetic Process Via Ornithine Monoatomic Anion Homeostasis Response To Biotin Ammonium Homeostasis
Pathways		Mitochondrial protein import Mitochondrial protein import Urea cycle
Drugs		Ornithine Citrulline N-(Phosphonoacetyl)-L-Ornithine Norvaline
Diseases		Ornithine transcarbamylase deficiency
GWAS
Interacting Genes		2 interacting genes: CFTR TOMM20
Entrez ID		5009
HPRD ID		08947
Ensembl ID		ENSG00000036473
Uniprot IDs		P00480
PDB IDs		1C9Y 1EP9 1FVO 1OTH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Protein-transporting ATPase Activity TRNA Import Into Mitochondrion Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Enamel Mineralization Migrasome Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization TRNA Transport RNA Import Into Mitochondrion TOM Complex Mitochondrion Targeting Sequence Binding Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Amelogenesis Mitochondrial Outer Membrane Translocase Complex ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Protein Insertion Into Mitochondrial Outer Membrane Golgi-associated Vesicle Membrane Cellular Response To Forskolin Mitochondrial Envelope Response To Forskolin Chloride Transmembrane Transporter Activity Sperm Capacitation Bicarbonate Transport Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Protein Import Into Mitochondrial Matrix Water Transport Protein Transmembrane Transporter Activity Multicellular Organismal-level Water Homeostasis Protein Targeting To Mitochondrion Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Ion Transmembrane Transporter Activity Cholesterol Biosynthetic Process 14-3-3 Protein Binding Fluid Transport Transmembrane Transport Transepithelial Transport Establishment Of Protein Localization To Mitochondrial Membrane Protein Insertion Into Mitochondrial Membrane Vesicle Docking Involved In Exocytosis
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