OCA2 and ATP13A2

Number of citations of the paper that reports this interaction (PMID 22645275)
9

Data Source:
BioGRID (two hybrid)

		OCA2	ATP13A2
Gene Name		oculocutaneous albinism II	ATPase type 13A2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Lysosomal Membrane Endoplasmic Reticulum Membrane Endosome Membrane Integral Component Of Membrane Melanosome Membrane	Lysosome Lysosomal Membrane Integral Component Of Membrane
	Molecular Function	Transporter Activity L-tyrosine Transmembrane Transporter Activity Protein Binding	Protein Binding ATP Binding ATPase Activity Metal Ion Binding
	Biological Process	Eye Pigment Biosynthetic Process Spermatid Development Cell Proliferation Tyrosine Transport Melanocyte Differentiation Melanin Biosynthetic Process Transmembrane Transport	Cation Transport Metabolic Process Cellular Response To Manganese Ion
Pathways
Drugs
Diseases
GWAS		Black vs. blond hair color ( 18483556) Black vs. red hair color ( 18483556) Blond vs. brown hair color ( 17952075) Blue vs. brown eyes ( 17952075) Blue vs. green eyes ( 17952075) Eye color ( 23548203 23118974 20585627) Hair color ( 20585627) Parkinson's disease (age of onset) ( 19772629) Vitiligo ( 22561518)	Height ( 20189936)
Protein-Protein Interactions		1 interactors: ATP13A2	36 interactors: ACKR3 ATP5G2 CCKBR CMTM6 COL1A1 CXCR4 CYGB DCAF7 EMC7 F2R FAM111B FAM192A FAM8A1 FKBP8 FUNDC2 GPR21 HIPK1 ICAM2 LMAN2 LRP6 MEX3B MYCBP2 NPY1R NRXN1 OCA2 OSTC PCDHB10 PCMTD2 PDIA6 SEC61B SPCS2 TSPAN14 UBE2J2 VAMP2 WDR5B WDR83OS
Entrez ID		4948	23400
HPRD ID		01945	13677
Ensembl ID		ENSG00000104044	ENSG00000159363
Uniprot IDs		Q04671	Q9NQ11
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Manganese Ion Response To Manganese Ion Cellular Response To Metal Ion Cellular Response To Inorganic Substance Response To Metal Ion	Positive Regulation Of Cytosolic Calcium Ion Concentration Cytosolic Calcium Ion Homeostasis Protein Localization To Membrane Embryonic Retina Morphogenesis In Camera-type Eye Establishment Of Protein Localization To Membrane Regulation Of Signaling Establishment Of Protein Localization Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Cellular Localization Membrane Organization Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cardiovascular System Development Synaptic Transmission Motor Neuron Axon Guidance Cell-cell Signaling Locomotion Positive Regulation Of Signal Transduction Chemotaxis Face Morphogenesis Embryonic Camera-type Eye Morphogenesis ER-associated Ubiquitin-dependent Protein Catabolic Process Head Morphogenesis Positive Regulation Of Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Canonical Wnt Signaling Pathway Involved In Cardiac Neural Crest Cell Differentiation Involved In Heart Development Negative Regulation Of Planar Cell Polarity Pathway Involved In Neural Tube Closure Negative Regulation Of Planar Cell Polarity Pathway Involved In Outflow Tract Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Pericardium Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Cardiac Right Atrium Morphogenesis Negative Regulation Of Renin Secretion Into Blood Stream Negative Regulation Of Planar Cell Polarity Pathway Involved In Cardiac Muscle Tissue Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Ventricular Septum Morphogenesis Cellular Response To Fluoride Protein Complex Assembly Involved In Synapse Maturation Gamma-aminobutyric Acid Receptor Clustering Tyrosine Transport Synapse Organization Protein Localization To Nucleus Embryonic Eye Morphogenesis Cellular Protein Localization Regulation Of Protein Secretion Cellular Metal Ion Homeostasis Response To External Stimulus Cellular Homeostasis Cerebellum Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Face Development Regulation Of Signal Transduction Cellular Protein Metabolic Process Regulation Of Insulin Secretion
Tagcloud ?		albinism bloc colocalize confocal constituents disrupt disrupted encoded hair hypopigmentation lamp2 localizations matp melanogenic melanosomal melanosomes misrouting oca4 oculocutaneous organelles pigmentation severely slc45a2 sorting subcellular trafficking transporters tyrosinase	ataxin atxn3 b12 cag cgg chediak coexist cytopathies fmr1 fragile gaucher gba glucocerebrosidase hereditary higashi idiopathic joseph kufor levodopa lyst machado park2 parkin parkinsonism pn polg1 premutation rakeb tremor
Tagcloud (Difference) ?		albinism bloc colocalize confocal constituents disrupt disrupted encoded hair hypopigmentation lamp2 localizations matp melanogenic melanosomal melanosomes misrouting oca4 oculocutaneous organelles pigmentation severely slc45a2 sorting subcellular trafficking transporters tyrosinase	ataxin atxn3 b12 cag cgg chediak coexist cytopathies fmr1 fragile gaucher gba glucocerebrosidase hereditary higashi idiopathic joseph kufor levodopa lyst machado park2 parkin parkinsonism pn polg1 premutation rakeb tremor
Tagcloud (Intersection) ?