ARK2C and UBE2W

Number of citations of the paper that reports this interaction (PubMedID 19690564)
61

Data Source:
BioGRID (two hybrid)

		ARK2C	UBE2W
Description		arkadia (RNF111) C-terminal like ring finger ubiquitin ligase 2C	ubiquitin conjugating enzyme E2 W
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GO Annotations	Cellular Component	Nucleus Protein-containing Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Polyubiquitination Axonogenesis Motor Neuron Axon Guidance Protein Catabolic Process Positive Regulation Of BMP Signaling Pathway Forelimb Morphogenesis Limb Development Innervation Muscle Structure Development	Protein Polyubiquitination DNA Repair Protein Monoubiquitination Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins DNA Damage Response Protein Ubiquitination Cellular Response To Nutrient Levels TORC1 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Cellular Response To Misfolded Protein Antiviral Innate Immune Response Negative Regulation Of TORC1 Signaling
Pathways			Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Cervical high-risk human papilloma virus infection ( 33225922) Malaria ( 31844061) Manganese levels ( 26025379) Urate levels in obese individuals ( 25811787)
Interacting Genes		8 interacting genes: UBC UBE2D1 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2W	81 interacting genes: AKR1C3 AMFR ARK2C ATXN3 BARD1 BFAR BIRC2 BIRC8 BRCA1 CADPS2 CBL CHFR CNOT4 DNMT3B DTX3 DTX3L DZIP3 EED FANCL LRSAM1 MAP3K1 MAPT MARCHF3 MARCHF5 MGRN1 MIB1 MID1 MKRN1 MKRN3 MUL1 PJA2 POLR2C PSTPIP1 RFWD3 RMND5B RNF10 RNF103 RNF111 RNF114 RNF123 RNF125 RNF138 RNF14 RNF150 RNF152 RNF166 RNF167 RNF183 RNF185 RNF2 RNF26 RNF31 RNF4 RNF5 RNF8 ROPN1 SNCA STUB1 TOPORS TRIM17 TRIM2 TRIM21 TRIM23 TRIM27 TRIM3 TRIM31 TRIM35 TRIM39 TRIM5 TRIM59 TRIM7 TRIM8 UBA1 UBOX5 UFM1 UHRF2 USHBP1 XIAP ZNRF1 ZNRF2 ZNRF4
Entrez ID		494470	55284
HPRD ID			07724
Ensembl ID		ENSG00000141622	ENSG00000104343
Uniprot IDs		A0A059NXK6 Q6ZSG1	Q96B02 Q96FI0 X6REH9
PDB IDs		5D0I 5D0K 5D0M 5ULH 5ULK 7R70 7R71	2A7L 2MT6 8A58
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Ubiquitination Protein Polyubiquitination Protein Modification By Small Protein Conjugation Protein Monoubiquitination Post-translational Protein Modification Modification-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein K11-linked Ubiquitination Protein Modification Process Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis ATP Binding Protein Metabolic Process Nucleotide Binding Transferase Activity Catabolic Process TORC1 Signaling Negative Regulation Of TORC1 Signaling Protein K63-linked Ubiquitination TOR Signaling Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Polyubiquitination Regulation Of TOR Signaling Proteasomal Protein Catabolic Process Macromolecule Metabolic Process Protein K6-linked Ubiquitination Regulation Of Protein Polyubiquitination Protein Catabolic Process Cellular Response To Nutrient Levels Nucleoplasm Ubiquitin Protein Ligase Binding Nucleus Negative Regulation Of BMP Signaling Pathway Antiviral Innate Immune Response Positive Regulation Of Protein Ubiquitination Response To Nutrient Levels Ubiquitin Ligase Complex Regulation Of BMP Signaling Pathway DNA Repair UBC13-MMS2 Complex Negative Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Post-translational Protein Modification ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Complex	Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein Modification Process Transferase Activity Zinc Ion Binding Protein Metabolic Process Metal Ion Binding Macromolecule Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Protein Autoubiquitination Proteolysis Catabolic Process Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein Catabolic Process Response To Stress Proteasomal Protein Catabolic Process Cellular Response To Stress Protein K6-linked Ubiquitination Ubiquitin Ligase Complex Regulation Of Intracellular Signal Transduction Protein Monoubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Signal Transduction Cytoplasm Canonical NF-kappaB Signal Transduction Suppression Of Viral Release By Host Positive Regulation Of Catabolic Process Innate Immune Response Immune System Process DNA Damage Response Positive Regulation Of Autophagy Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Response To Other Organism Regulation Of Autophagy Regulation Of Signaling Regulation Of Cell Communication Regulation Of Defense Response Defense Response To Symbiont Endoplasmic Reticulum Mannose Trimming Intracellular Signal Transduction Defense Response To Other Organism Response To External Biotic Stimulus
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