STT3B and AADAT

Data Source: HiPPIP (Novel)

		STT3B	AADAT
Name		STT3 oligosaccharyltransferase complex catalytic subunit B	aminoadipate aminotransferase
Structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Oligosaccharyltransferase Complex Membrane Protein-containing Complex Oligosaccharyltransferase Complex B	Mitochondrion Mitochondrial Matrix
	Molecular Function	Oligosaccharyl Transferase Activity Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Metal Ion Binding	Transaminase Activity Kynurenine-oxoglutarate Transaminase Activity Transferase Activity Pyridoxal Phosphate Binding Protein Homodimerization Activity Kynurenine-glyoxylate Transaminase Activity 2-aminoadipate Transaminase Activity Glycine:2-oxoglutarate Aminotransferase Activity Methionine-glyoxylate Transaminase Activity
	Biological Process	Protein Glycosylation Protein N-linked Glycosylation Glycoprotein Catabolic Process Response To Unfolded Protein Protein N-linked Glycosylation Via Asparagine ERAD Pathway Post-translational Protein Modification	2-oxoglutarate Metabolic Process Glutamate Metabolic Process L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine Kynurenine Metabolic Process Alpha-amino Acid Metabolic Process
Pathways		Asparagine N-linked glycosylation Maturation of spike protein Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition PD-L1(CD274) glycosylation and translocation to plasma membrane	Lysine catabolism Tryptophan catabolism
Drugs		None	Pyridoxal phosphate Glutamic acid
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134 ) Diabetic retinopathy in type 2 diabetes ( 33607655 ) Periodontal disease-related phenotype (Socransky) ( 24347629 ) Urate levels ( 31578528 )	Adult body size ( 32376654 ) Alcohol consumption ( 31358974 ) Free thyroxine concentration ( 25743335 ) Metabolite levels ( 23823483 ) Thyroid hormone levels ( 23408906 )
Novel Interactors		10 novel interactors: AADAT CAMLG CYP51A1 DDR2 EIF4H GNMT OXSR1 SATB1 SMARCC1 XYLB	1 novel interactors: STT3B
Interacting Genes		2 interacting genes: FILNC1 INCA1	None recorded
Entrez ID		201595	51166
HPRD ID		12268	12392
Ensembl ID		ENSG00000163527	ENSG00000109576
Uniprot IDs		Q8TCJ2	Q4W5N8 Q8N5Z0
PDB IDs		6S7T	2QLR 2R2N 2VGZ 2XH1 3DC1 3UE8 4GDY 4GE4 4GE7 4GE9 4GEB 5EFS 5EUN 5TF5 6D0A 6T8P 6T8Q
GO Terms Enriched among Interactors		Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Sterol 14-demethylase Activity Cholesterol Biosynthetic Process Via 24,25-dihydrolanosterol Xylulose Catabolic Process D-xylulokinase Activity Aspartate Family Amino Acid Metabolic Process Glycine N-methyltransferase Activity Methionine-glyoxylate Transaminase Activity Glycine:2-oxoglutarate Aminotransferase Activity 2-aminoadipate Transaminase Activity Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Hepatic Stellate Cell Proliferation Protein Tyrosine Kinase Collagen Receptor Activity RNA Strand-exchange Activity Eukaryotic Translation Initiation Factor 4F Complex Assembly Xylulose Metabolic Process Sarcosine Metabolic Process S-adenosylhomocysteine Metabolic Process Kynurenine-glyoxylate Transaminase Activity GET Complex Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Phosphorylation Regulation Of Fibroblast Proliferation D-xylose Metabolic Process L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine	Oligosaccharyl Transferase Activity Oligosaccharyltransferase Complex B Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity Oligosaccharyltransferase Complex Protein N-linked Glycosylation Via Asparagine Glycoprotein Catabolic Process ERAD Pathway Response To Unfolded Protein Protein N-linked Glycosylation Protein Glycosylation Macromolecule Glycosylation Glycosylation Glycosyltransferase Activity Carbohydrate Derivative Catabolic Process Glycoprotein Biosynthetic Process Response To Endoplasmic Reticulum Stress Glycoprotein Metabolic Process