ACR and SERPINA5

Number of citations of the paper that reports this interaction (PMID 7521127)
4

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		ACR	SERPINA5
Gene Name		acrosin	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Golgi-associated Vesicle Acrosomal Matrix Protein Complex	Acrosomal Membrane Extracellular Region Extracellular Space External Side Of Plasma Membrane Membrane Platelet Alpha Granule Platelet Dense Tubular Network Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-TMPRSS11E Complex Protein C Inhibitor-PLAT Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-thrombin Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Protein Complex Extracellular Vesicular Exosome Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-coagulation Factor XI Complex
	Molecular Function	DNA Binding Amidase Activity Serine-type Endopeptidase Activity Copper Ion Binding Protein Binding Mannose Binding Drug Binding Zinc Ion Binding Fucose Binding	Retinoic Acid Binding Protease Binding Serine-type Endopeptidase Inhibitor Activity Glycosaminoglycan Binding Heparin Binding Phosphatidylcholine Binding Acrosin Binding
	Biological Process	Acrosome Matrix Dispersal Activation Of Adenylate Cyclase Activity Single Fertilization Binding Of Sperm To Zona Pellucida Acrosome Reaction Penetration Of Zona Pellucida Multicellular Organism Reproduction Response To Steroid Hormone	Lipid Transport Spermatogenesis Fusion Of Sperm To Egg Plasma Membrane Blood Coagulation Negative Regulation Of Endopeptidase Activity
Pathways		Acrosome Reaction Fertilization	Common Pathway Intrinsic Pathway Formation of Fibrin Clot (Clotting Cascade)
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: SERPINA5 ZP2 ZP3	20 interactors: ACR COPS6 F10 F11 F2 FGA FGB FGG HRSP12 KLK1 KLK2 KLK3 KLKB1 PIAS4 PLAT PLAU PROC RCHY1 SEMG2 THBD
Entrez ID		49	5104
HPRD ID		06342	03503
Ensembl ID		ENSG00000100312	ENSG00000188488
Uniprot IDs		P10323	B3KTV6 B4DDH1 B4DPC7 P05154
PDB IDs			1LQ8 1PAI 2HI9 2OL2 2PAI 3DY0
Enriched GO Terms of Interacting Partners?		Single Fertilization Fertilization Binding Of Sperm To Zona Pellucida Sperm-egg Recognition Cell-cell Recognition Sexual Reproduction Multicellular Organism Reproduction Cell Recognition Reproduction Positive Regulation Of Ovarian Follicle Development Positive Regulation Of Antral Ovarian Follicle Growth Positive Regulation Of Acrosomal Vesicle Exocytosis Positive Regulation Of Type IV Hypersensitivity Single Organism Reproductive Process Reproductive Process Egg Coat Formation Regulation Of Ovarian Follicle Development Negative Regulation Of Binding Of Sperm To Zona Pellucida Positive Regulation Of Phosphatidylinositol Biosynthetic Process Positive Regulation Of Phospholipid Biosynthetic Process Positive Regulation Of Acrosome Reaction Prevention Of Polyspermy Positive Regulation Of Hypersensitivity Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Manganese Ion Transmembrane Transport Regulation Of Acrosome Reaction Manganese Ion Transport Positive Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Female Gonad Development Positive Regulation Of Calcium Ion Import Fusion Of Sperm To Egg Plasma Membrane Positive Regulation Of Humoral Immune Response Gamete Generation Positive Regulation Of Calcium Ion-dependent Exocytosis Plasma Membrane Fusion Egg Activation Regulation Of Calcium Ion Import Positive Regulation Of Interleukin-4 Production Multicellular Organismal Reproductive Process Positive Regulation Of Acute Inflammatory Response Protein Kinase C Signaling Regulation Of Interleukin-4 Production Intracellular Protein Transport Blastocyst Formation Oocyte Development Oocyte Differentiation Regulation Of Humoral Immune Response Positive Regulation Of Interferon-gamma Production Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Lipid Biosynthetic Process	Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Regulation Of Blood Coagulation Blood Coagulation Hemostasis Regulation Of Wound Healing Regulation Of Body Fluid Levels Wound Healing Response To Wounding Regulation Of Fibrinolysis Blood Coagulation, Intrinsic Pathway Plasminogen Activation Fibrinolysis Proteolysis Protein Activation Cascade Positive Regulation Of Fibrinolysis Positive Regulation Of Heterotypic Cell-cell Adhesion Peptidyl-glutamic Acid Carboxylation Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Endothelial Cell Apoptotic Process Protein Metabolic Process Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Zymogen Activation Factor XII Activation Positive Regulation Of Vasoconstriction Regulation Of Substrate Adhesion-dependent Cell Spreading Response To Stress Regulation Of Endothelial Cell Apoptotic Process Platelet Aggregation Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Vasoconstriction Platelet Activation Positive Regulation Of Exocytosis Regulation Of Cell-substrate Adhesion Platelet Degranulation Negative Regulation Of Fibrinolysis Acute Inflammatory Response Plasma Kallikrein-kinin Cascade Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Peptide Hormone Secretion Protein Processing Positive Regulation Of Peptide Secretion Extracellular Matrix Disassembly Protein Polymerization Positive Regulation Of Hormone Secretion Negative Regulation Of Platelet Activation Response To Calcium Ion
Tagcloud ?		allelic asymptomatic bacilli cassette crystallin cultures deltaacr equivalent establish exchange growing h37rv homologue hpt hygromycin hypoxic infectivity latent logarithmically macrophages maintenance mildly mtb mycobacterium replaced stationary thp undetectable viability	across agr2 assigned differently effector endocrine ergs estradiol exploitable greb1 interpretation menstrual mirroring pdzk1 pgr premenopausal progesterone rankl responsiveness rhythm runx1 tff1 tumours varies w1 w2 w3 windows
Tagcloud (Difference) ?		allelic asymptomatic bacilli cassette crystallin cultures deltaacr equivalent establish exchange growing h37rv homologue hpt hygromycin hypoxic infectivity latent logarithmically macrophages maintenance mildly mtb mycobacterium replaced stationary thp undetectable viability	across agr2 assigned differently effector endocrine ergs estradiol exploitable greb1 interpretation menstrual mirroring pdzk1 pgr premenopausal progesterone rankl responsiveness rhythm runx1 tff1 tumours varies w1 w2 w3 windows
Tagcloud (Intersection) ?