ACR and ZP3

Number of citations of the paper that reports this interaction (PMID 11739644)
6

Data Source:
HPRD (in vitro)

		ACR	ZP3
Gene Name		acrosin	zona pellucida glycoprotein 3 (sperm receptor)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Golgi-associated Vesicle Acrosomal Matrix Protein Complex	Acrosomal Vesicle Outer Acrosomal Membrane Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Cytoplasm Multivesicular Body Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Membrane Secretory Granule Extracellular Matrix Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Binding Amidase Activity Serine-type Endopeptidase Activity Copper Ion Binding Protein Binding Mannose Binding Drug Binding Zinc Ion Binding Fucose Binding	Signal Transducer Activity Manganese Ion Transmembrane Transporter Activity Protein Binding Store-operated Calcium Channel Activity Carbohydrate Binding Acrosin Binding
	Biological Process	Acrosome Matrix Dispersal Activation Of Adenylate Cyclase Activity Single Fertilization Binding Of Sperm To Zona Pellucida Acrosome Reaction Penetration Of Zona Pellucida Multicellular Organism Reproduction Response To Steroid Hormone	Positive Regulation Of Type IV Hypersensitivity Blastocyst Formation Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Leukocyte Migration Positive Regulation Of Humoral Immune Response Manganese Ion Transport Intracellular Protein Transport Single Fertilization Binding Of Sperm To Zona Pellucida Positive Regulation Of Phosphatidylinositol Biosynthetic Process Multicellular Organism Reproduction Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-4 Production Intracellular Signal Transduction Egg Coat Formation Positive Regulation Of T Cell Proliferation Positive Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Phosphatidylinositol-mediated Signaling Oocyte Development Positive Regulation Of Inflammatory Response Positive Regulation Of Protein Kinase B Signaling Protein Kinase C Signaling Calcium Ion Transmembrane Transport Manganese Ion Transmembrane Transport Positive Regulation Of Calcium Ion Import Positive Regulation Of Acrosome Reaction Negative Regulation Of Binding Of Sperm To Zona Pellucida Positive Regulation Of Acrosomal Vesicle Exocytosis Positive Regulation Of Ovarian Follicle Development Positive Regulation Of Antral Ovarian Follicle Growth
Pathways		Acrosome Reaction Fertilization	Interaction With The Zona Pellucida Fertilization
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: SERPINA5 ZP2 ZP3	9 interactors: ACR ENGASE FURIN MICALL1 MRPS16 OR2L13 PCDH17 SPACA3 UBAP2L
Entrez ID		49	7784
HPRD ID		06342	01690
Ensembl ID		ENSG00000100312	ENSG00000188372
Uniprot IDs		P10323	P21754
PDB IDs
Enriched GO Terms of Interacting Partners?		Single Fertilization Fertilization Binding Of Sperm To Zona Pellucida Sperm-egg Recognition Cell-cell Recognition Sexual Reproduction Multicellular Organism Reproduction Cell Recognition Reproduction Positive Regulation Of Ovarian Follicle Development Positive Regulation Of Antral Ovarian Follicle Growth Positive Regulation Of Acrosomal Vesicle Exocytosis Positive Regulation Of Type IV Hypersensitivity Single Organism Reproductive Process Reproductive Process Egg Coat Formation Regulation Of Ovarian Follicle Development Negative Regulation Of Binding Of Sperm To Zona Pellucida Positive Regulation Of Phosphatidylinositol Biosynthetic Process Positive Regulation Of Phospholipid Biosynthetic Process Positive Regulation Of Acrosome Reaction Prevention Of Polyspermy Positive Regulation Of Hypersensitivity Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Manganese Ion Transmembrane Transport Regulation Of Acrosome Reaction Manganese Ion Transport Positive Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Female Gonad Development Positive Regulation Of Calcium Ion Import Fusion Of Sperm To Egg Plasma Membrane Positive Regulation Of Humoral Immune Response Gamete Generation Positive Regulation Of Calcium Ion-dependent Exocytosis Plasma Membrane Fusion Egg Activation Regulation Of Calcium Ion Import Positive Regulation Of Interleukin-4 Production Multicellular Organismal Reproductive Process Positive Regulation Of Acute Inflammatory Response Protein Kinase C Signaling Regulation Of Interleukin-4 Production Intracellular Protein Transport Blastocyst Formation Oocyte Development Oocyte Differentiation Regulation Of Humoral Immune Response Positive Regulation Of Interferon-gamma Production Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Lipid Biosynthetic Process	Sperm-egg Recognition Cell-cell Recognition Cell Recognition Single Fertilization Fertilization Binding Of Sperm To Zona Pellucida Acrosome Matrix Dispersal Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Slow Endocytic Recycling Nerve Growth Factor Production Negative Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Receptor Catabolic Process Nerve Growth Factor Processing Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Production Cell Wall Macromolecule Catabolic Process Sexual Reproduction Monocyte Activation Protein Localization To Endosome Peptidoglycan Catabolic Process Retrograde Transport, Endosome To Plasma Membrane Viral Protein Processing Positive Regulation Of Macrophage Activation Positive Regulation Of Membrane Protein Ectodomain Proteolysis Peptidyl-glutamic Acid Carboxylation Reproduction
Tagcloud ?		allelic asymptomatic bacilli cassette crystallin cultures deltaacr equivalent establish exchange growing h37rv homologue hpt hygromycin hypoxic infectivity latent logarithmically macrophages maintenance mildly mtb mycobacterium replaced stationary thp undetectable viability	blastocyst build careful cdx2 correct embryo embryogenesis embryos epiblast filmed generates genotyped gives icm individually loxp morula onwards oocyte placenta pluripotent pools segregation specification starts te trophectoderm unambiguously zygotic
Tagcloud (Difference) ?		allelic asymptomatic bacilli cassette crystallin cultures deltaacr equivalent establish exchange growing h37rv homologue hpt hygromycin hypoxic infectivity latent logarithmically macrophages maintenance mildly mtb mycobacterium replaced stationary thp undetectable viability	blastocyst build careful cdx2 correct embryo embryogenesis embryos epiblast filmed generates genotyped gives icm individually loxp morula onwards oocyte placenta pluripotent pools segregation specification starts te trophectoderm unambiguously zygotic
Tagcloud (Intersection) ?