ACR and ZP3

Number of citations: 0 (PubMedID 11739644)
Data Source: HPRD (in vitro)

		ACR	ZP3
Name		acrosin	zona pellucida glycoprotein 3
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Extracellular Region Nucleus Golgi-associated Vesicle Protein-containing Complex Acrosomal Matrix	Extracellular Region Extracellular Space Plasma Membrane Membrane Extracellular Matrix Egg Coat
	Molecular Function	Protease Binding DNA Binding Amidase Activity Serine-type Endopeptidase Activity Copper Ion Binding Protein Binding D-mannose Binding Peptidase Activity Serine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Fucose Binding	Extracellular Matrix Structural Constituent Protein Binding Carbohydrate Binding Acrosin Binding Structural Constituent Of Egg Coat Identical Protein Binding Receptor Ligand Activity
	Biological Process	Acrosome Matrix Dispersal Proteolysis Activation Of Adenylate Cyclase Activity Single Fertilization Binding Of Sperm To Zona Pellucida Acrosome Reaction Penetration Of Zona Pellucida Protein Catabolic Process Response To Steroid Hormone	Positive Regulation Of Type IV Hypersensitivity Blastocyst Formation Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Leukocyte Migration Positive Regulation Of Humoral Immune Response Signal Transduction Single Fertilization Binding Of Sperm To Zona Pellucida Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-4 Production Egg Coat Formation Positive Regulation Of T Cell Proliferation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Oocyte Development Positive Regulation Of Inflammatory Response Positive Regulation Of Acrosome Reaction Negative Regulation Of Binding Of Sperm To Zona Pellucida Positive Regulation Of Acrosomal Vesicle Exocytosis Positive Regulation Of Ovarian Follicle Development Positive Regulation Of Antral Ovarian Follicle Growth
Pathways		Acrosome Reaction and Sperm:Oocyte Membrane Binding	Interaction With Cumulus Cells And The Zona Pellucida
GWAS		No GWAS studies recorded	Parkinson disease and lewy body pathology ( 25663231 )
Interacting Genes		3 interacting genes: SERPINA5 ZP2 ZP3	11 interacting genes: ACR CLDN11 ENGASE FURIN MALL MICALL1 MRPS16 OR2L13 PCDH17 SPACA3 UBAP2L
Entrez ID		49	7784
HPRD ID		06342	01690
Ensembl ID		ENSG00000100312	ENSG00000188372
Uniprot IDs		P10323	P21754
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Acrosin Binding Structural Constituent Of Egg Coat Egg Coat Single Fertilization Fertilization Regulation Of Acrosome Reaction Binding Of Sperm To Zona Pellucida Extracellular Matrix Sperm-egg Recognition Cell-cell Recognition Negative Regulation Of Reproductive Process Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-TMPRSS11E Complex Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Protein C Inhibitor-thrombin Complex Protein C Inhibitor-coagulation Factor XI Complex Protein C Inhibitor-PLAT Complex Cell Recognition Positive Regulation Of Type IV Hypersensitivity Positive Regulation Of Antral Ovarian Follicle Growth Seminal Clot Liquefaction Regulation Of Reproductive Process Positive Regulation Of Acrosomal Vesicle Exocytosis Positive Regulation Of Ovarian Follicle Development Egg Coat Formation Reproductive Process Platelet Dense Tubular Network Regulation Of Acrosomal Vesicle Exocytosis Negative Regulation Of Binding Of Sperm To Zona Pellucida Regulation Of Type IV Hypersensitivity Prevention Of Polyspermy Regulation Of Binding Of Sperm To Zona Pellucida Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of Ovarian Follicle Development Positive Regulation Of Hypersensitivity Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Acrosome Reaction Regulation Of Fertilization Extracellular Region Positive Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Acute Inflammatory Response To Antigenic Stimulus Oocyte Development Positive Regulation Of Calcium Ion-dependent Exocytosis Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Platelet Alpha Granule Plasma Membrane Fusion	Acrosomal Matrix Sperm-egg Recognition Cell-cell Recognition Cell Recognition Binding Of Sperm To Zona Pellucida Acrosome Matrix Dispersal Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Mannosyl-glycoprotein Endo-beta-N-acetylglucosaminidase Activity Cytoplasmic Side Of Endosome Membrane Amidase Activity Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Slow Endocytic Recycling Axon Ensheathment Negative Regulation Of Receptor Catabolic Process Presynaptic Active Zone Assembly Protease Binding Acrosomal Vesicle Viral Translation Viral Life Cycle Serine-type Peptidase Activity Plasma Membrane Organization Cytokine Precursor Processing Nerve Growth Factor Binding Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Transforming Growth Factor Beta1 Production Regulation Of Synaptic Vesicle Clustering Serine-type Endopeptidase Activity Fucose Binding Positive Regulation Of Stress Granule Assembly Lysozyme Activity