ACR and ZP2

Number of citations of the paper that reports this interaction (PMID 11739644)
6

Data Source:
HPRD (in vitro)

		ACR	ZP2
Gene Name		acrosin	zona pellucida glycoprotein 2 (sperm receptor)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Golgi-associated Vesicle Acrosomal Matrix Protein Complex	Extracellular Region Proteinaceous Extracellular Matrix Multivesicular Body Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Membrane Secretory Granule Extracellular Matrix
	Molecular Function	DNA Binding Amidase Activity Serine-type Endopeptidase Activity Copper Ion Binding Protein Binding Mannose Binding Drug Binding Zinc Ion Binding Fucose Binding	Coreceptor Activity Acrosin Binding
	Biological Process	Acrosome Matrix Dispersal Activation Of Adenylate Cyclase Activity Single Fertilization Binding Of Sperm To Zona Pellucida Acrosome Reaction Penetration Of Zona Pellucida Multicellular Organism Reproduction Response To Steroid Hormone	Manganese Ion Transport Intracellular Protein Transport Signal Transduction Single Fertilization Binding Of Sperm To Zona Pellucida Multicellular Organism Reproduction Regulation Of Acrosome Reaction Prevention Of Polyspermy
Pathways		Acrosome Reaction Fertilization	Interaction With The Zona Pellucida Fertilization
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: SERPINA5 ZP2 ZP3	2 interactors: ACR ZPBP
Entrez ID		49	7783
HPRD ID		06342	01689
Ensembl ID		ENSG00000100312	ENSG00000103310
Uniprot IDs		P10323	Q05996
PDB IDs
Enriched GO Terms of Interacting Partners?		Single Fertilization Fertilization Binding Of Sperm To Zona Pellucida Sperm-egg Recognition Cell-cell Recognition Sexual Reproduction Multicellular Organism Reproduction Cell Recognition Reproduction Positive Regulation Of Ovarian Follicle Development Positive Regulation Of Antral Ovarian Follicle Growth Positive Regulation Of Acrosomal Vesicle Exocytosis Positive Regulation Of Type IV Hypersensitivity Single Organism Reproductive Process Reproductive Process Egg Coat Formation Regulation Of Ovarian Follicle Development Negative Regulation Of Binding Of Sperm To Zona Pellucida Positive Regulation Of Phosphatidylinositol Biosynthetic Process Positive Regulation Of Phospholipid Biosynthetic Process Positive Regulation Of Acrosome Reaction Prevention Of Polyspermy Positive Regulation Of Hypersensitivity Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Manganese Ion Transmembrane Transport Regulation Of Acrosome Reaction Manganese Ion Transport Positive Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Female Gonad Development Positive Regulation Of Calcium Ion Import Fusion Of Sperm To Egg Plasma Membrane Positive Regulation Of Humoral Immune Response Gamete Generation Positive Regulation Of Calcium Ion-dependent Exocytosis Plasma Membrane Fusion Egg Activation Regulation Of Calcium Ion Import Positive Regulation Of Interleukin-4 Production Multicellular Organismal Reproductive Process Positive Regulation Of Acute Inflammatory Response Protein Kinase C Signaling Regulation Of Interleukin-4 Production Intracellular Protein Transport Blastocyst Formation Oocyte Development Oocyte Differentiation Regulation Of Humoral Immune Response Positive Regulation Of Interferon-gamma Production Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Lipid Biosynthetic Process	Binding Of Sperm To Zona Pellucida Sperm-egg Recognition Cell-cell Recognition Cell Recognition Single Fertilization Fertilization Acrosome Matrix Dispersal Sexual Reproduction Multicellular Organism Reproduction Acrosome Assembly Reproduction Acrosome Reaction Activation Of Adenylate Cyclase Activity Single Organism Reproductive Process Positive Regulation Of Adenylate Cyclase Activity Reproductive Process Secretory Granule Organization Calcium Ion-dependent Exocytosis Positive Regulation Of Lyase Activity Regulation Of Adenylate Cyclase Activity Positive Regulation Of CAMP Biosynthetic Process Regulation Of Cyclase Activity Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Spermatid Development Spermatid Differentiation Vesicle Organization
Tagcloud ?		allelic asymptomatic bacilli cassette crystallin cultures deltaacr equivalent establish exchange growing h37rv homologue hpt hygromycin hypoxic infectivity latent logarithmically macrophages maintenance mildly mtb mycobacterium replaced stationary thp undetectable viability	bird coat deglycosylated disc egg eggs enzymatically follicles germinal glycoproteins glycosylated granulosa heavily immature immunohistological maturing oocyte ovulated pellucida penetration preferential sperm surrounded yellow zona zp3 zp4 zpd
Tagcloud (Difference) ?		allelic asymptomatic bacilli cassette crystallin cultures deltaacr equivalent establish exchange growing h37rv homologue hpt hygromycin hypoxic infectivity latent logarithmically macrophages maintenance mildly mtb mycobacterium replaced stationary thp undetectable viability	bird coat deglycosylated disc egg eggs enzymatically follicles germinal glycoproteins glycosylated granulosa heavily immature immunohistological maturing oocyte ovulated pellucida penetration preferential sperm surrounded yellow zona zp3 zp4 zpd
Tagcloud (Intersection) ?