CNOT8 and CNOT4

Number of citations of the paper that reports this interaction (PubMedID 10637334)
44

Data Source:
HPRD (two hybrid)

		CNOT8	CNOT4
Description		CCR4-NOT transcription complex subunit 8	CCR4-NOT transcription complex subunit 4
Image		No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol CCR4-NOT Complex CCR4-NOT Core Complex	Nucleus Cytoplasm Cytosol CCR4-NOT Complex
	Molecular Function	3'-5'-RNA Exonuclease Activity Nucleic Acid Binding RNA Binding Nuclease Activity Exonuclease Activity Poly(A)-specific Ribonuclease Activity Protein Binding Hydrolase Activity Metal Ion Binding	Nucleic Acid Binding RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Regulation Of Translation Positive Regulation Of Cell Population Proliferation Regulatory NcRNA-mediated Gene Silencing MiRNA-mediated Gene Silencing By MRNA Destabilization Positive Regulation Of MRNA Catabolic Process	Nuclear-transcribed MRNA Poly(A) Tail Shortening Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Regulation Of Megakaryocyte Differentiation Protein Autoubiquitination
Pathways		Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain M-decay: degradation of maternal mRNAs by maternally stored factors	Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain M-decay: degradation of maternal mRNAs by maternally stored factors
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494)	Appendicular lean mass ( 33097823) Clostridioides difficle infection ( 33841421) Heel bone mineral density ( 30598549) Household income (MTAG) ( 31844048) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Meat-related diet ( 32066663) Numerical cognitive ability ( 31620175)
Interacting Genes		11 interacting genes: BTG1 BTG2 BTG3 CNOT1 CNOT2 CNOT3 CNOT4 CNOT6 CRYAA PRMT1 TOB2	18 interacting genes: BCAS2 CNOT1 CNOT3 CNOT6 CNOT8 EP300 IL36RN KDM5C RBM15 UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2W
Entrez ID		9337	4850
HPRD ID		07225	05369
Ensembl ID		ENSG00000155508	ENSG00000080802
Uniprot IDs		B7Z9U0 E5RHL9 Q9UFF9	O95628
PDB IDs			1E4U 1UR6
Enriched GO Terms of Interacting Partners?		CCR4-NOT Complex Nuclear-transcribed MRNA Poly(A) Tail Shortening CCR4-NOT Core Complex Nuclear-transcribed MRNA Catabolic Process Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly MRNA Catabolic Process Negative Regulation Of Gene Expression Poly(A)-specific Ribonuclease Activity Regulation Of Translation RNA Catabolic Process Trophectodermal Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Nucleobase-containing Compound Catabolic Process Negative Regulation Of Metabolic Process Regulatory NcRNA-mediated Gene Silencing Regulation Of Stem Cell Population Maintenance Regulation Of Developmental Process Nucleus Regulation Of Gene Expression MRNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening P-body Positive Regulation Of Organelle Assembly Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of MRNA Catabolic Process Cytoplasm Nucleic Acid Metabolic Process Regulation Of Multicellular Organismal Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of MRNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Translation Regulation Of RNA Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Megakaryocyte Differentiation Regulation Of Intracellular Estrogen Receptor Signaling Pathway Macromolecule Catabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Myeloid Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Organelle Assembly GATOR1 Complex Binding	Ubiquitin Conjugating Enzyme Activity Macromolecule Catabolic Process Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein K48-linked Ubiquitination Catabolic Process Protein K11-linked Ubiquitination CCR4-NOT Complex Protein Monoubiquitination Nuclear-transcribed MRNA Poly(A) Tail Shortening Protein Ubiquitination Protein Modification By Small Protein Conjugation CCR4-NOT Core Complex Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Modification-dependent Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Proteolysis Involved In Protein Catabolic Process Poly(A)-specific Ribonuclease Activity Negative Regulation Of Biosynthetic Process TORC1 Signaling Nucleus Nucleic Acid Metabolic Process Protein K63-linked Ubiquitination Protein Modification Process TOR Signaling Transferase Activity Regulation Of TORC1 Signaling ATP Binding Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Negative Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Proteolysis Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Regulation Of TOR Signaling Nucleotide Binding Nucleobase-containing Compound Catabolic Process Regulatory NcRNA-mediated Gene Silencing Protein Catabolic Process Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process RNA Catabolic Process Negative Regulation Of TORC1 Signaling Protein Autoubiquitination Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Metabolic Process
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