CNOT8 and BTG1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid, pull down, two hybrid)
HPRD (in vitro)

		CNOT8	BTG1
Description		CCR4-NOT transcription complex subunit 8	BTG anti-proliferation factor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol CCR4-NOT Complex CCR4-NOT Core Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	3'-5'-RNA Exonuclease Activity Nucleic Acid Binding RNA Binding Nuclease Activity Exonuclease Activity Poly(A)-specific Ribonuclease Activity Protein Binding Hydrolase Activity Metal Ion Binding	Transcription Coregulator Activity Protein Binding Enzyme Binding Kinase Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Regulation Of Translation Positive Regulation Of Cell Population Proliferation Regulatory NcRNA-mediated Gene Silencing MiRNA-mediated Gene Silencing By MRNA Destabilization Positive Regulation Of MRNA Catabolic Process	Regulation Of DNA-templated Transcription Response To Oxidative Stress Spermatogenesis Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Cell Migration Negative Regulation Of Cell Growth Response To Peptide Hormone Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Fibroblast Apoptotic Process
Pathways		Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain M-decay: degradation of maternal mRNAs by maternally stored factors	FOXO-mediated transcription of cell cycle genes
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494)	Heart failure ( 20445134) Metabolite levels ( 23823483) Schizophrenia ( 28991256 29483656 30285260)
Interacting Genes		11 interacting genes: BTG1 BTG2 BTG3 CNOT1 CNOT2 CNOT3 CNOT4 CNOT6 CRYAA PRMT1 TOB2	16 interacting genes: CCNA2 CDKN2D CNOT7 CNOT8 FADD GRB2 HOXB9 NCK2 PRMT1 RARA RNF181 SKP2 THRA THRB TUBA1A XRCC6
Entrez ID		9337	694
HPRD ID		07225	15912
Ensembl ID		ENSG00000155508	ENSG00000133639
Uniprot IDs		B7Z9U0 E5RHL9 Q9UFF9	P62324 Q6IBC8
PDB IDs
Enriched GO Terms of Interacting Partners?		CCR4-NOT Complex Nuclear-transcribed MRNA Poly(A) Tail Shortening CCR4-NOT Core Complex Nuclear-transcribed MRNA Catabolic Process Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly MRNA Catabolic Process Negative Regulation Of Gene Expression Poly(A)-specific Ribonuclease Activity Regulation Of Translation RNA Catabolic Process Trophectodermal Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Nucleobase-containing Compound Catabolic Process Negative Regulation Of Metabolic Process Regulatory NcRNA-mediated Gene Silencing Regulation Of Stem Cell Population Maintenance Regulation Of Developmental Process Nucleus Regulation Of Gene Expression MRNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening P-body Positive Regulation Of Organelle Assembly Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of MRNA Catabolic Process Cytoplasm Nucleic Acid Metabolic Process Regulation Of Multicellular Organismal Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of MRNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Translation Regulation Of RNA Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Megakaryocyte Differentiation Regulation Of Intracellular Estrogen Receptor Signaling Pathway Macromolecule Catabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Myeloid Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Organelle Assembly GATOR1 Complex Binding	Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Positive Regulation Of RNA Metabolic Process Female Courtship Behavior Positive Regulation Of Macromolecule Metabolic Process Retinoic Acid Receptor Signaling Pathway Nucleobase-containing Compound Metabolic Process Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulator Complex Regulation Of Nucleobase-containing Compound Metabolic Process Thyroid Hormone Binding Positive Regulation Of Lymphocyte Activation MRNA Transcription By RNA Polymerase II Regulation Of Thyroid Hormone Receptor Signaling Pathway CCR4-NOT Core Complex Protein-containing Complex Binding Macromolecule Metabolic Process Nuclear Receptor Activity Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Activation MRNA Transcription Regulation Of Female Receptivity Female Mating Behavior Regulation Of Protein Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Translation Type I Pneumocyte Differentiation Regulation Of RNA Metabolic Process DNA-templated Transcription Protein Domain Specific Binding Poly(A)-specific Ribonuclease Activity Cytosol Chromatin DNA Binding Regulation Of Lymphocyte Activation Positive Regulation Of T Cell Activation CCR4-NOT Complex Nucleobase-containing Compound Biosynthetic Process Gland Development Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Leukocyte Cell-cell Adhesion Nuclear Receptor-mediated Signaling Pathway
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