CNOT8 and BTG2

Number of citations of the paper that reports this interaction (PMID 11136725)
30

Data Source:
HPRD (in vivo, in vitro)

		CNOT8	BTG2
Gene Name		CCR4-NOT transcription complex, subunit 8	BTG family, member 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Cytosol CCR4-NOT Complex	Extracellular Vesicular Exosome
	Molecular Function	3'-5'-exoribonuclease Activity Sequence-specific DNA Binding Transcription Factor Activity RNA Binding Poly(A)-specific Ribonuclease Activity Protein Binding Metal Ion Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Translation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Gene Expression Gene Silencing By MiRNA Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Positive Regulation Of MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	DNA Repair Transcription, DNA-templated Protein Methylation Cellular Response To DNA Damage Stimulus Negative Regulation Of Cell Proliferation Associative Learning Response To Mechanical Stimulus Anterior/posterior Pattern Specification Response To Organic Cyclic Compound Negative Regulation Of Translation Dentate Gyrus Development Central Nervous System Neuron Development Neuron Projection Development Skeletal Muscle Cell Differentiation Response To Peptide Hormone Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Electrical Stimulus Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Neural Precursor Cell Proliferation
Pathways		Deadenylation of mRNA Deadenylation-dependent mRNA decay
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: BTG1 BTG2 CNOT1 CNOT2 CNOT3 CNOT4 CNOT6 PRMT1 TOB2	13 interactors: CNOT7 CNOT8 DYT10 HMGN1 HOXB9 HOXC8 PICK1 PRKCA PRMT1 SKP2 SMAD1 SMAD9 SRA1
Entrez ID		9337	7832
HPRD ID		07225	03357
Ensembl ID		ENSG00000155508	ENSG00000159388
Uniprot IDs		B0AZS3 B7Z8R1 Q9UFF9	P78543
PDB IDs			3DJU 3E9V
Enriched GO Terms of Interacting Partners?		Nuclear-transcribed MRNA Poly(A) Tail Shortening Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MRNA 3'-end Processing RNA 3'-end Processing Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Nuclear-transcribed MRNA Catabolic Process Regulation Of Cytoplasmic MRNA Processing Body Assembly MRNA Catabolic Process RNA Catabolic Process Gene Silencing By RNA Regulation Of Translation Gene Silencing Regulation Of Stem Cell Maintenance Positive Regulation Of Organelle Assembly RNA Phosphodiester Bond Hydrolysis, Exonucleolytic MRNA Processing Aromatic Compound Catabolic Process Posttranscriptional Regulation Of Gene Expression MRNA Metabolic Process RNA Processing Regulation Of Cell Differentiation Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cellular Macromolecule Catabolic Process RNA Phosphodiester Bond Hydrolysis Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of MRNA 3'-end Processing Regulation Of Gene Expression Trophectodermal Cell Differentiation Positive Regulation Of MRNA Catabolic Process Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Gene Expression Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Gene Silencing By MiRNA Blastocyst Formation Posttranscriptional Gene Silencing Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Component Biogenesis Nucleic Acid Phosphodiester Bond Hydrolysis Regulation Of RNA Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Catabolic Process RNA Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Organelle Organization Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Myeloid Cell Differentiation	Gene Silencing By MiRNA Posttranscriptional Gene Silencing Regulation Of Gene Expression, Epigenetic Gene Silencing By RNA Skeletal System Development Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Gene Silencing Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Cell Proliferation Transcription, DNA-templated Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of MRNA Catabolic Process RNA Biosynthetic Process Positive Regulation Of Metabolic Process Gene Expression Positive Regulation Of Cellular Biosynthetic Process Heterocycle Metabolic Process Nuclear-transcribed MRNA Poly(A) Tail Shortening Cellular Aromatic Compound Metabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Cellular Nitrogen Compound Metabolic Process Cartilage Development Regulation Of Transcription From RNA Polymerase II Promoter RNA Processing Developmental Process Nitrogen Compound Metabolic Process Connective Tissue Development System Development Negative Regulation Of Cell Proliferation Regulation Of Cellular Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Transcription, DNA-templated RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Cell Proliferation Multicellular Organismal Development Positive Regulation Of Gene Expression BMP Signaling Pathway Cellular Macromolecule Biosynthetic Process Anatomical Structure Development
Tagcloud ?			abolished androgen ar attenuated attenuates cisplatin directed dosage element expressions fragment ggaaaggaa ggaaagtcc gggcacc gggcagagccc go lncap mutagenesis nfkappab null p53 partly pc prostate psa repressed treatments upregulation upstream
Tagcloud (Difference) ?			abolished androgen ar attenuated attenuates cisplatin directed dosage element expressions fragment ggaaaggaa ggaaagtcc gggcacc gggcagagccc go lncap mutagenesis nfkappab null p53 partly pc prostate psa repressed treatments upregulation upstream
Tagcloud (Intersection) ?