TBXT and NFIA

Number of citations of the paper that reports this interaction (PubMedID 35140242)
106

Data Source:
BioGRID (proximity labelling technology, pull down)

		TBXT	NFIA
Description		T-box transcription factor T	nuclear factor I A
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Chromatin Nucleus Nucleoplasm Cell Junction
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Mesoderm Formation Cell Fate Specification Somitogenesis Heart Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Signal Transduction Mesoderm Development Anterior/posterior Axis Specification, Embryo Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cardiac Muscle Cell Myoblast Differentiation Primitive Streak Formation	Cell Morphogenesis DNA Replication Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Response To Wounding Exit From Mitosis Gene Expression Glial Cell Proliferation Viral Genome Replication Glial Cell Fate Specification Neurogenesis BMP Signaling Pathway Limb Morphogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Specification Generation Of Neurons Cartilage Development Retina Development In Camera-type Eye Synapse Maturation Neural Precursor Cell Proliferation Ureter Development
Pathways		Cardiogenesis Germ layer formation at gastrulation Epithelial-Mesenchymal Transition (EMT) during gastrulation Formation of paraxial mesoderm Formation of axial mesoderm Formation of definitive endoderm	RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation
Drugs
Diseases
GWAS			Arthritis (oligoarticular juvenile idiopathic) ( 34101054) Autism ( 30675382) Bipolar disorder ( 21738484) Blond vs. brown/black hair color ( 30531825) Celiac disease ( 20190752 25920553 30572963) Cobalt levels ( 26025379) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic conduction measures ( 23463857) Electrocardiographic traits (multivariate) ( 32602732) Erectile dysfunction ( 30583798) Feeling nervous ( 29500382) General risk tolerance (MTAG) ( 30643258) Global electrical heterogeneity phenotypes ( 29622589) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 28552196) Homeostasis model assessment of insulin resistance ( 33381925) JT interval (sulfonylurea treatment interaction) ( 27958378) Myopia ( 27182965) Number of sexual partners ( 30643258) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) PR interval ( 32439900) QRS duration ( 27577874 27659466 30679814) QT interval (sulfonylurea treatment interaction) ( 27958378) Refractive error ( 32231278) Regular attendance at a religious group ( 29970889) Risk-taking tendency (4-domain principal component model) ( 30643258) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997) Triglyceride levels ( 32203549)
Interacting Genes		3 interacting genes: NFIA NFIB NFIC	20 interacting genes: CREBBP ELK3 ERG ETV7 FBXO7 FOS FOXL1 GABARAPL1 GATA2 GATA3 KLF16 KLF8 LHX2 LHX3 NHLH1 PLEKHF2 SFN SMAD2 TBXT UBC
Entrez ID		6862	4774
HPRD ID		03236	09007
Ensembl ID		ENSG00000164458	ENSG00000162599
Uniprot IDs		J3KP65 O15178	Q12857
PDB IDs		5QRF 5QRG 5QRH 5QRI 5QRJ 5QRK 5QRL 5QRM 5QRN 5QRO 5QRP 5QRQ 5QRR 5QRS 5QRT 5QRU 5QRV 5QRW 5QRX 5QRY 5QRZ 5QS0 5QS1 5QS2 5QS3 5QS4 5QS5 5QS6 5QS7 5QS8 5QS9 5QSA 5QSB 5QSC 5QSD 5QSE 5QSF 5QSG 5QSH 5QSI 5QSJ 5QSK 5QSL 5QT0 6F58 6F59 6ZU8 7HI8 7HI9 7ZK2 7ZKF 7ZL2 8A10 8A7N 8CDN 8FMU
Enriched GO Terms of Interacting Partners?		Glial Cell Fate Specification DNA Replication Exit From Mitosis Generation Of Neurons Neuron Fate Specification Glial Cell Proliferation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Retina Development In Camera-type Eye Cell Fate Specification DNA-binding Transcription Factor Activity Neural Precursor Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Lung Ciliated Cell Differentiation Neurogenesis DNA Metabolic Process Double-stranded DNA Binding Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Macromolecule Biosynthetic Process Cell Differentiation Involved In Salivary Gland Development Fibrillar Center Negative Regulation Of Mesenchymal Cell Proliferation Involved In Lung Development Brain Renin-angiotensin System Positive Regulation Of Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Principal Sensory Nucleus Of Trigeminal Nerve Development Developmental Maturation Chromatin Response To Wounding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Club Cell Differentiation Positive Regulation Of Macromolecule Metabolic Process Salivary Gland Cavitation Anterior Commissure Morphogenesis Ribosomal Protein S6 Kinase Activity Regulation Of Blood Volume By Renin-angiotensin Positive Regulation Of Transcription By RNA Polymerase II Ureter Development Positive Regulation Of Metabolic Process Gene Expression Multi-ciliated Epithelial Cell Differentiation Type II Pneumocyte Differentiation Cerebellar Mossy Fiber Negative Regulation Of Mesenchymal Cell Proliferation Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Animal Organ Development Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Type I Pneumocyte Differentiation Negative Regulation Of Meiotic Nuclear Division Macromolecule Biosynthetic Process	Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific DNA Binding DNA-binding Transcription Factor Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cell Differentiation Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coactivator Binding Cellular Developmental Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of Primary Metabolic Process Transcription Regulator Complex Neuroepithelial Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Chromatin Binding Transcription Coregulator Binding Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Thyroid-stimulating Hormone-secreting Cell Differentiation Regulation Of Macromolecule Metabolic Process Positive Regulation Of MiRNA Transcription Mesoderm Development RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Neuron Differentiation Positive Regulation Of MiRNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Developmental Process Positive Regulation Of Biosynthetic Process
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