NFE2L2 and PRKCH

Number of citations of the paper that reports this interaction (PMID 19920073)
28

Data Source:
BioGRID (enzymatic study)

		NFE2L2	PRKCH
Gene Name		nuclear factor, erythroid 2-like 2	protein kinase C, eta
Image
Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Plasma Membrane	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Extracellular Vesicular Exosome
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Transcription Cofactor Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Transcription Regulatory Region DNA Binding	Protein Kinase C Activity Calcium-independent Protein Kinase C Activity ATP Binding Ral GTPase Binding Enzyme Binding Metal Ion Binding
	Biological Process	Transcription From RNA Polymerase II Promoter Proteasomal Ubiquitin-independent Protein Catabolic Process Positive Regulation Of Gene Expression Protein Ubiquitination Positive Regulation Of Blood Coagulation Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Embryonic Development Cellular Response To Hydrogen Peroxide Cellular Response To Tumor Necrosis Factor Cellular Response To Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hydrogen Peroxide-induced Cell Death Regulation Of Removal Of Superoxide Radicals Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process	Protein Phosphorylation Signal Transduction Blood Coagulation Positive Regulation Of Macrophage Derived Foam Cell Differentiation Platelet Activation Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Glial Cell Proliferation Protein Kinase C Signaling Regulation Of Tight Junction Assembly
Pathways			G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK G alpha (z) signalling events Platelet activation, signaling and aggregation Effects of PIP2 hydrolysis
Drugs
Diseases
GWAS			Obesity (early onset extreme) ( 23563609) Reading and spelling ( 23738518) Rheumatoid arthritis ( 22446963) Word reading ( 23738518)
Protein-Protein Interactions		35 interactors: ATF4 BPTF CASP1 CASP3 CHD6 COPS7A CREB3 CREBBP DYT10 EIF2AK3 GSK3B JUN JUND KEAP1 KPNA3 MAFF MAFG MAFK MAPK7 NCOR2 NFE2 NFE2L3 PMF1 PPARG PRKCA PRKCD PRKCG PRKCH PRKCQ RBMX SUMO1 TNNT1 TRIM24 UBE2E2 WAC	13 interactors: BANP CDK2 FYN GSK3A ITGB2 NFE2L2 NUMB PARD6A PPP1R14A PRKD1 PTPN11 SRC ZBTB8OS
Entrez ID		4780	5583
HPRD ID		02732	05669
Ensembl ID		ENSG00000116044	ENSG00000027075
Uniprot IDs		Q16236	P24723
PDB IDs		2FLU 2LZ1 3ZGC	2FK9 3TXO
Enriched GO Terms of Interacting Partners?		Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Response To Stress Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Cellular Response To Organic Substance Regulation Of Metabolic Process Transcription, DNA-templated Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Response To Organic Substance Regulation Of Body Fluid Levels Regulation Of Apoptotic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Regulation Of Cell Death Response To Stimulus Transcription From RNA Polymerase II Promoter Response To Wounding Cellular Metabolic Process Negative Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Blood Coagulation Cellular Macromolecule Biosynthetic Process RNA Metabolic Process Hemostasis Cellular Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Innate Immune Response Regulation Of Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cellular Response To Stimulus Regulation Of Cellular Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Hydrolase Activity	Cellular Response To Growth Factor Stimulus Response To Growth Factor Integrin-mediated Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Blood Coagulation Innate Immune Response Hemostasis Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Immune Response-regulating Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Protein Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Leukocyte Migration Neurotrophin Signaling Pathway T Cell Costimulation Regulation Of Body Fluid Levels Chemotaxis Fc Receptor Signaling Pathway Wound Healing Regulation Of Cellular Response To Insulin Stimulus Cellular Response To Platelet-derived Growth Factor Stimulus Cellular Response To Peptide Hormone Stimulus Response To Platelet-derived Growth Factor Negative Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ephrin Receptor Signaling Pathway Cellular Response To Peptide Cellular Response To Organic Substance Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Wounding Activated T Cell Proliferation Cell Proliferation Locomotion Immune Response Regulation Of Phosphorylation Defense Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Signal Transduction Axon Guidance Cell Migration Phosphatidylinositol-mediated Signaling Response To Oxidative Stress Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Movement Of Cell Or Subcellular Component Regulation Of Phosphorus Metabolic Process Cell Motility
Tagcloud ?		adapt anionic cannabidiol cannabinoid cbd combinatorial endowed gbm gsc gscs id1 mes modulators pn proneural psychoactive redox regrowth renewal reprogramming resist ros slc7a11 solute sox2 taqman therapeutics xc xct	adjust adora2a avp cart cecal clp gng7 intramuscular ku myh7 oxt pde1b pdyn preconditioning prkcd puncture ratref reproduced rgs9 rxrg s100a8 sepsis six3 slc17a6 slco1a5 sostdc1 tac1 ttr ulinastatin
Tagcloud (Difference) ?		adapt anionic cannabidiol cannabinoid cbd combinatorial endowed gbm gsc gscs id1 mes modulators pn proneural psychoactive redox regrowth renewal reprogramming resist ros slc7a11 solute sox2 taqman therapeutics xc xct	adjust adora2a avp cart cecal clp gng7 intramuscular ku myh7 oxt pde1b pdyn preconditioning prkcd puncture ratref reproduced rgs9 rxrg s100a8 sepsis six3 slc17a6 slco1a5 sostdc1 tac1 ttr ulinastatin
Tagcloud (Intersection) ?