NEUROG1 and TARBP2

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		NEUROG1	TARBP2
Description		neurogenin 1	TARBP2 subunit of RISC loading complex
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Neuronal Cell Body Perikaryon	Nucleus Nucleoplasm Cytoplasm Cytosol RISC Complex Nuclear Body Perinuclear Region Of Cytoplasm RISC-loading Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Protein Dimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding	RNA Binding Double-stranded RNA Binding Protein Binding Enzyme Binding SiRNA Binding MiRNA Binding Pre-mRNA Binding Identical Protein Binding Protein Homodimerization Activity Pre-miRNA Binding Protein Sequestering Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Thorax And Anterior Abdomen Determination Nervous System Development Sensory Organ Development Exit From Mitosis Trigeminal Nerve Development Vestibulocochlear Nerve Formation Neurogenesis Cell Differentiation Neuron Differentiation Peristalsis Forebrain Development Auditory Behavior Positive Regulation Of Exit From Mitosis Genitalia Morphogenesis Inner Ear Morphogenesis Cell Fate Commitment Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Muscle Organ Development Genitalia Development Inner Ear Development Neuromuscular Process Controlling Balance Positive Regulation Of DNA-binding Transcription Factor Activity Axon Development Mastication Cochlea Development Cochlea Morphogenesis Craniofacial Suture Morphogenesis Learned Vocalization Behavior Negative Regulation Of Relaxation Of Muscle Negative Regulation Of Saliva Secretion Hard Palate Morphogenesis	Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Translation Negative Regulation Of Protein Kinase Activity Spermatid Development Single Fertilization Post-transcriptional Regulation Of Gene Expression SiRNA Processing Regulatory NcRNA-mediated Gene Silencing Pre-miRNA Processing MiRNA Processing Multicellular Organism Growth Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Skeletal Muscle Tissue Regeneration Positive Regulation Of Viral Genome Replication Positive Regulation Of Translation Regulation Of Viral Transcription Negative Regulation Of Defense Response To Virus By Host Positive Regulation Of Muscle Cell Differentiation Regulation Of Protein Metabolic Process Neural Precursor Cell Proliferation Protein K63-linked Ubiquitination Regulation Of Regulatory NcRNA Processing Regulation Of SiRNA Processing RISC Complex Assembly Global Gene Silencing By MRNA Cleavage Regulation Of MiRNA Processing
Pathways			MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis PKR-mediated signaling
Drugs
Diseases
GWAS			Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		7 interacting genes: CBFA2T2 CREBBP RUNX1T1 SMAD1 TARBP2 TCF12 TCF4	32 interacting genes: ADARB1 AGO2 APP CDK9 DICER1 EIF2AK2 FOXP1 HDHD2 HSPB1 IKBKG KCNIP3 MAPK8IP2 MED21 NEDD4L NEUROG1 NF2 NKRF NUDT18 OGT PNKP PRKRA RBM14 RNF10 TCEA2 TCEANC TGIF2 TOP1 TRAF4 VAV2 ZMAT3 ZMAT4 ZNF346
Entrez ID		4762	6895
HPRD ID		03430	05446
Ensembl ID		ENSG00000181965	ENSG00000139546
Uniprot IDs		F1T0H3 Q92886	Q15633
PDB IDs			2CPN 3ADL 3LLH 4WYQ 5N8L 5N8M 5ZAK 5ZAL 5ZAM 6ZBK
Enriched GO Terms of Interacting Partners?		Transcription Regulator Complex Transcription Corepressor Activity DNA-binding Transcription Factor Binding MiRNA Processing Nucleoplasm Regulation Of Cell Differentiation E-box Binding DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Nucleic Acid Metabolic Process Nucleus Histone H3K27 Acetyltransferase Activity Chromatin Homomeric SMAD Protein Complex DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Cell Differentiation Regulation Of SiRNA Processing Positive Regulation Of Neuron Differentiation Regulation Of RNA Metabolic Process Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Mesodermal Cell Fate Commitment Osteoblast Fate Commitment Global Gene Silencing By MRNA Cleavage Beta-catenin-TCF7L2 Complex Mpp10 Complex Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Developmental Process Negative Regulation Of Defense Response To Virus By Host TFIIB-class Transcription Factor Binding RNA Metabolic Process Regulation Of Developmental Process MRF Binding Regulation Of Transcription By RNA Polymerase II Regulation Of Muscle Cell Differentiation Positive Regulation Of Neuron Projection Development Anti-Mullerian Hormone Receptor Signaling Pathway Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Protein Dimerization Activity	Double-stranded RNA Binding Nucleus Negative Regulation Of Schwann Cell Proliferation RISC-loading Complex SiRNA Processing RISC Complex Assembly SiRNA Binding Regulation Of Primary Metabolic Process Pre-miRNA Processing Regulation Of Macromolecule Metabolic Process Negative Regulation Of Glial Cell Proliferation Regulation Of Transcription By RNA Polymerase II Nucleic Acid Binding Regulation Of Metabolic Process RNA Endonuclease Activity Producing 5'-phosphomonoesters, Hydrolytic Mechanism Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleoplasm MiRNA Processing Cell Death Programmed Cell Death Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Translational Initiation Regulation Of Glial Cell Proliferation Negative Regulation Of Gliogenesis Defense Response To Symbiont Regulation Of RNA Metabolic Process Regulation Of Nervous System Process Defense Response To Other Organism RNA Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Pre-miRNA Binding Response To External Biotic Stimulus Regulation Of Macromolecule Biosynthetic Process Defense Response Innate Immune Response Response To Other Organism Apoptotic Process Negative Regulation Of Osteoblast Proliferation Positive Regulation Of Metabolic Process Regulation Of Tumor Necrosis Factor Production Nucleolus Regulation Of Programmed Cell Death Endonuclease Activity Regulation Of Developmental Process Response To Stress Negative Regulation Of Cell Population Proliferation Regulation Of Cell Migration
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