NEUROG1 and RUNX1T1

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		NEUROG1	RUNX1T1
Description		neurogenin 1	RUNX1 partner transcriptional co-repressor 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Neuronal Cell Body Perikaryon	Nucleus Nucleoplasm Nuclear Matrix
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Protein Dimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding	DNA Binding Transcription Corepressor Activity Protein Binding Zinc Ion Binding Metal Ion Binding DNA-binding Transcription Factor Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Thorax And Anterior Abdomen Determination Nervous System Development Sensory Organ Development Exit From Mitosis Trigeminal Nerve Development Vestibulocochlear Nerve Formation Neurogenesis Cell Differentiation Neuron Differentiation Peristalsis Forebrain Development Auditory Behavior Positive Regulation Of Exit From Mitosis Genitalia Morphogenesis Inner Ear Morphogenesis Cell Fate Commitment Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Muscle Organ Development Genitalia Development Inner Ear Development Neuromuscular Process Controlling Balance Positive Regulation Of DNA-binding Transcription Factor Activity Axon Development Mastication Cochlea Development Cochlea Morphogenesis Craniofacial Suture Morphogenesis Learned Vocalization Behavior Negative Regulation Of Relaxation Of Muscle Negative Regulation Of Saliva Secretion Hard Palate Morphogenesis	DNA-templated Transcription Negative Regulation Of Fat Cell Differentiation Negative Regulation Of DNA-templated Transcription
Pathways
Drugs
Diseases			Acute myeloid leukemia (AML)
GWAS			Adult body size ( 32376654) Chronotype ( 30696823) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549) Intelligence (MTAG) ( 29326435) Number of sexual partners ( 30643258) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070) Plasma anti-thyroglobulin levels ( 29678681) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking initiation ( 30617275 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		7 interacting genes: CBFA2T2 CREBBP RUNX1T1 SMAD1 TARBP2 TCF12 TCF4	99 interacting genes: ABI3 ADAMTSL4 ARHGAP9 ATN1 BCL6 BIRC2 BRCA1 BRME1 CBFA2T3 CBY2 CCDC197 CDC23 CDR2 CEP170P1 CEP83 COG6 CPSF7 CREB3L1 DEUP1 DNMT1 EFHC2 EPS8 ETS1 FAM136A FAM9A GFI1 GSE1 HDAC1 HDAC3 HDAC8 HOMER3 HOXB2 HSP90AA1 ID1 ID3 IHO1 KIAA0408 KIFC3 KPNA1 KPNB1 KRT23 KRT27 KRT33B KRT35 KRTAP13-3 KRTAP19-6 KRTAP6-2 KRTAP6-3 LHX3 LPXN LZTS1 LZTS2 MEOX2 MID2 NCOR1 NCOR2 NECAB2 NEUROG1 OIP5 PCBD2 PIAS2 PLSCR3 PRDM16 PRDM6 PRKAR1B PRKAR2A RAD54L2 REL RNF4 RTN4IP1 SH3RF1 SIN3A SORBS3 SPEN SPRY2 STX11 SYCE1 TAF9B TAL2 TCF12 TCF3 TCF4 TEKT1 TFIP11 TRIM42 TRIM54 UBQLN4 VDR VPS52 WBP11 XIAP ZBTB16 ZFP36 ZFP90 ZMAT1 ZMYM4 ZNF343 ZNF652 ZNF655
Entrez ID		4762	862
HPRD ID		03430	00590
Ensembl ID		ENSG00000181965	ENSG00000079102
Uniprot IDs		F1T0H3 Q92886	A0A0A0MSU1 B2R6I9 E5RH72 Q06455 W8FW32
PDB IDs			1WQ6 2DJ8 2H7B 2KNH 2KYG 2OD1 2ODD 2PP4 4JOL
Enriched GO Terms of Interacting Partners?		Transcription Regulator Complex Transcription Corepressor Activity DNA-binding Transcription Factor Binding MiRNA Processing Nucleoplasm Regulation Of Cell Differentiation E-box Binding DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Nucleic Acid Metabolic Process Nucleus Histone H3K27 Acetyltransferase Activity Chromatin Homomeric SMAD Protein Complex DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Cell Differentiation Regulation Of SiRNA Processing Positive Regulation Of Neuron Differentiation Regulation Of RNA Metabolic Process Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Mesodermal Cell Fate Commitment Osteoblast Fate Commitment Global Gene Silencing By MRNA Cleavage Beta-catenin-TCF7L2 Complex Mpp10 Complex Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Developmental Process Negative Regulation Of Defense Response To Virus By Host TFIIB-class Transcription Factor Binding RNA Metabolic Process Regulation Of Developmental Process MRF Binding Regulation Of Transcription By RNA Polymerase II Regulation Of Muscle Cell Differentiation Positive Regulation Of Neuron Projection Development Anti-Mullerian Hormone Receptor Signaling Pathway Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Protein Dimerization Activity	Transcription Repressor Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Binding Regulation Of Transcription By RNA Polymerase II Transcription Corepressor Activity Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II DNA Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Heterochromatin Formation Regulation Of Primary Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Protein Decrotonylase Activity Histone Decrotonylase Activity Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Negative Regulation Of Androgen Receptor Signaling Pathway Transcription Cis-regulatory Region Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Intermediate Filament Histone Deacetylase Complex Regulation Of Apoptotic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Programmed Cell Death Zinc Ion Binding Transcription Corepressor Binding Chromatin Positive Regulation Of Neuron Differentiation RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Metabolic Process E-box Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Histone Deacetylase Activity, Hydrolytic Mechanism Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Epigenetic Regulation Of Gene Expression DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process
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