NEU1 and PBX2

		NEU1	PBX2
Description		neuraminidase 1	PBX homeobox 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Lysosome Lysosomal Membrane Plasma Membrane Membrane Cell Junction Cytoplasmic Vesicle Specific Granule Lumen Lysosomal Lumen Extracellular Exosome	Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	Exo-alpha-sialidase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Alpha-sialidase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding DNA-binding Transcription Factor Binding
	Biological Process	Lipid Metabolic Process Ganglioside Catabolic Process Oligosaccharide Catabolic Process Lipid Catabolic Process	Eye Development Regulation Of DNA-templated Transcription Brain Development Animal Organ Morphogenesis Proximal/distal Pattern Formation Embryonic Limb Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Neuron Development
Pathways		Sialic acid metabolism Defective NEU1 causes sialidosis Neutrophil degranulation Glycosphingolipid catabolism
Drugs		Oseltamivir Celecoxib Acetylsalicylic acid
Diseases		Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD) Sialidosis; Mucolipidosis I Galactosialidosis
GWAS		A body shape index ( 34021172) Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Basal cell carcinoma ( 27539887) Estimated glomerular filtration rate ( 31152163) Inflammatory bowel disease ( 28067908) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Small cell lung carcinoma ( 28604730) Squamous cell lung carcinoma ( 28604730) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172)	Advanced age-related macular degeneration ( 26691988) Anxiety ( 33859377) Asthma ( 21804548 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 26876947) Coronary artery disease ( 33020668) Crohn's disease ( 23266558) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Moderate to vigorous physical activity levels ( 29899525) Prostate cancer ( 23535732) Refractive error ( 32231278) Rheumatic heart disease ( 32488134) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172)
Interacting Genes		30 interacting genes: AQP6 CCR9 CD79A CERS3 CERS4 CREB3 CREB3L1 CTSA EBP EEF1A1 ERGIC3 ERRFI1 GLB1 GOLM1 GPR152 GPX8 HSD17B11 JUNB KCNA2 KCNA4 LIG4 LMNA MGST3 MUC1 SLC10A1 SLC10A6 SLC18A1 SLC39A9 TMEM14B UBC	38 interacting genes: BAIAP2 BFSP2 BLOC1S1 BLOC1S5 BRMS1L CARD9 CCDC88B CDCA7L CENPBD1P COPS6 DCTN3 EFHC1 ELP1 FAM90A1 HOXA1 HOXA5 HOXA9 HOXB5 HOXB8 HOXC5 HOXC8 HOXC9 MCRS1 MSC MTREX NUP62 PBX1 PKNOX1 PPFIBP1 RIPPLY2 RPL4 RPS6KC1 SMYD3 TTC3 UBE2E1 ZCWPW2 ZDHHC7 ZNF587
Entrez ID		4758	5089
HPRD ID		09751	08890
Ensembl ID		ENSG00000204386	ENSG00000204304
Uniprot IDs		Q5JQI0 Q99519	A0A024RCR3 P40425
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Bile Acid:sodium Symporter Activity Integrated Stress Response Signaling Sphingosine N-acyltransferase Activity Regulation Of Chaperone-mediated Autophagy Lung Vasculature Development Negative Regulation Of Apoptotic Signaling Pathway Vasculature Development RNA Polymerase II Transcription Regulator Complex Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Type B Pancreatic Cell Proliferation Endoplasmic Reticulum Regulation Of Cardiac Muscle Hypertrophy	Anterior/posterior Pattern Specification Embryonic Skeletal System Development Regionalization DNA-binding Transcription Factor Activity Pattern Specification Process Skeletal System Morphogenesis Sequence-specific Double-stranded DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Embryonic Skeletal System Morphogenesis Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process Embryonic Morphogenesis Skeletal System Development RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Embryonic Organ Morphogenesis Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Animal Organ Morphogenesis Proximal/distal Pattern Formation Nucleoplasm Regulation Of Gene Expression Anatomical Structure Morphogenesis Regulation Of Macromolecule Biosynthetic Process Nucleus Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II BLOC-1 Complex Anterograde Synaptic Vesicle Transport DNA Binding Hemopoiesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Myeloid Cell Differentiation
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