NEU1 and CTSA

Number of citations of the paper that reports this interaction (PMID 9501080)
15

Data Source:
BioGRID (affinity chromatography technology, biochemical)
HPRD (in vitro, in vivo)

		NEU1	CTSA
Gene Name		sialidase 1 (lysosomal sialidase)	cathepsin A
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosome Lysosomal Membrane Plasma Membrane Cytoplasmic Membrane-bounded Vesicle Cell Junction Lysosomal Lumen Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome	Nucleoplasm Lysosome Endoplasmic Reticulum Membrane Lysosomal Lumen Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome
	Molecular Function	Exo-alpha-sialidase Activity Exo-alpha-(2->3)-sialidase Activity Exo-alpha-(2->6)-sialidase Activity Exo-alpha-(2->8)-sialidase Activity	Carboxypeptidase Activity Serine-type Carboxypeptidase Activity Enzyme Activator Activity
	Biological Process	Dolichol-linked Oligosaccharide Biosynthetic Process Sphingolipid Metabolic Process Glycosphingolipid Metabolic Process Oligosaccharide Catabolic Process Lipid Catabolic Process Protein N-linked Glycosylation Via Asparagine Post-translational Protein Modification Cellular Protein Metabolic Process Small Molecule Metabolic Process	Dolichol-linked Oligosaccharide Biosynthetic Process Proteolysis Sphingolipid Metabolic Process Glycosphingolipid Metabolic Process Intracellular Protein Transport Protein N-linked Glycosylation Via Asparagine Positive Regulation Of Catalytic Activity Post-translational Protein Modification Cellular Protein Metabolic Process Small Molecule Metabolic Process
Pathways		Diseases of glycosylation Metabolism of lipids and lipoproteins Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MOGS causes MOGS-CDG (CDG-2b) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Sphingolipid metabolism Defective ALG3 causes ALG3-CDG (CDG-1d) Glycosphingolipid metabolism Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Synthesis of substrates in N-glycan biosythesis Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective RFT1 causes RFT1-CDG (CDG-1n) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Sialic acid metabolism Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins	Diseases of glycosylation Metabolism of lipids and lipoproteins Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MOGS causes MOGS-CDG (CDG-2b) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 MHC class II antigen presentation Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Sphingolipid metabolism Defective ALG3 causes ALG3-CDG (CDG-1d) Glycosphingolipid metabolism Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Synthesis of substrates in N-glycan biosythesis Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective RFT1 causes RFT1-CDG (CDG-1n) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Sialic acid metabolism Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins Adaptive Immune System
Drugs		Oseltamivir
Diseases
GWAS
Protein-Protein Interactions		7 interactors: CTSA EEF1A1 GLB1 JUNB KCNA2 KCNA4 LIG4	3 interactors: GLB1 LAMP2 NEU1
Entrez ID		4758	5476
HPRD ID		09751	02020
Ensembl ID		ENSG00000204386	ENSG00000064601
Uniprot IDs		Q5JQI0 Q99519	B4E324 P10619
PDB IDs			1IVY 3BP4 3BP7 3BXN 4AZ0 4AZ3
Enriched GO Terms of Interacting Partners?		Dolichol-linked Oligosaccharide Biosynthetic Process Glycosphingolipid Metabolic Process DNA Ligation Involved In DNA Recombination Protein N-linked Glycosylation Via Asparagine Protein N-linked Glycosylation Optic Nerve Structural Organization Cellular Response To Metal Ion Glycolipid Metabolic Process Cellular Response To Inorganic Substance Sphingolipid Metabolic Process Potassium Ion Transmembrane Transport Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Post-translational Protein Modification Potassium Ion Transport Lagging Strand Elongation Pro-B Cell Differentiation Galactose Catabolic Process Membrane Lipid Metabolic Process Establishment Of Integrated Proviral Latency Protein Homooligomerization Osteoblast Proliferation Immunoglobulin V(D)J Recombination Establishment Of Viral Latency T Cell Receptor V(D)J Recombination Optic Nerve Morphogenesis DNA Ligation Involved In DNA Repair Keratan Sulfate Catabolic Process Lymphoid Progenitor Cell Differentiation Embryonic Process Involved In Female Pregnancy Response To Metal Ion Protein Glycosylation Macromolecule Glycosylation Leukocyte Differentiation Glycosylation DNA Ligation Optic Nerve Development Nucleotide-excision Repair, DNA Gap Filling Biosynthetic Process Cellular Response To Lithium Ion Glycoprotein Biosynthetic Process Anatomical Structure Arrangement Regulation Of Ion Transmembrane Transport Protein Oligomerization Single Strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Dopamine Secretion Glycoprotein Metabolic Process Response To Radiation Galactose Metabolic Process	Dolichol-linked Oligosaccharide Biosynthetic Process Glycosphingolipid Metabolic Process Protein N-linked Glycosylation Via Asparagine Protein N-linked Glycosylation Glycolipid Metabolic Process Carbohydrate Catabolic Process Sphingolipid Metabolic Process Post-translational Protein Modification Membrane Lipid Metabolic Process Macromolecule Glycosylation Protein Glycosylation Glycosylation Galactose Catabolic Process Glycoprotein Biosynthetic Process Glycoprotein Metabolic Process Oligosaccharide Catabolic Process Keratan Sulfate Catabolic Process Galactose Metabolic Process Keratan Sulfate Metabolic Process Peptidyl-amino Acid Modification Cellular Lipid Metabolic Process Carbohydrate Metabolic Process Oligosaccharide Metabolic Process Glycosaminoglycan Catabolic Process Lipid Metabolic Process Platelet Degranulation Protein Stabilization Catabolic Process Regulation Of Protein Stability Glycosaminoglycan Metabolic Process Platelet Activation Hexose Metabolic Process Pathogenesis Small Molecule Metabolic Process
Tagcloud ?		ablated archived bloody cadherins cd31 chemodrug dosages grading heterotopic intraperitoneally invasiveness mb mda neovascularization op oseltamivir pecam postimplantation rag2xcgamma ragxcgamma relapses reproducibly shrinking sialidase tetrazolium tnbc tnbcs vascularization wst	advancing aggregating award awg bring collaborations collaborative consulting formal funded funding institutions intellectual inventions kfc licensee mission ncats nih offices partnerships ppp quickly science sciences sector tto ttos universities
Tagcloud (Difference) ?		ablated archived bloody cadherins cd31 chemodrug dosages grading heterotopic intraperitoneally invasiveness mb mda neovascularization op oseltamivir pecam postimplantation rag2xcgamma ragxcgamma relapses reproducibly shrinking sialidase tetrazolium tnbc tnbcs vascularization wst	advancing aggregating award awg bring collaborations collaborative consulting formal funded funding institutions intellectual inventions kfc licensee mission ncats nih offices partnerships ppp quickly science sciences sector tto ttos universities
Tagcloud (Intersection) ?