NEU1 and KCNA4

Number of citations of the paper that reports this interaction (PMID 10896669)
44

Data Source:
BioGRID (enzymatic study)

		NEU1	KCNA4
Gene Name		sialidase 1 (lysosomal sialidase)	potassium channel, voltage gated shaker related subfamily A, member 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosome Lysosomal Membrane Plasma Membrane Cytoplasmic Membrane-bounded Vesicle Cell Junction Lysosomal Lumen Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Potassium Channel Complex Integral Component Of Membrane Axon
	Molecular Function	Exo-alpha-sialidase Activity Exo-alpha-(2->3)-sialidase Activity Exo-alpha-(2->6)-sialidase Activity Exo-alpha-(2->8)-sialidase Activity	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Potassium Ion Binding
	Biological Process	Dolichol-linked Oligosaccharide Biosynthetic Process Sphingolipid Metabolic Process Glycosphingolipid Metabolic Process Oligosaccharide Catabolic Process Lipid Catabolic Process Protein N-linked Glycosylation Via Asparagine Post-translational Protein Modification Cellular Protein Metabolic Process Small Molecule Metabolic Process	Potassium Ion Transport Synaptic Transmission Regulation Of Ion Transmembrane Transport Protein Homooligomerization Potassium Ion Transmembrane Transport
Pathways		Diseases of glycosylation Metabolism of lipids and lipoproteins Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MOGS causes MOGS-CDG (CDG-2b) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Sphingolipid metabolism Defective ALG3 causes ALG3-CDG (CDG-1d) Glycosphingolipid metabolism Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Synthesis of substrates in N-glycan biosythesis Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective RFT1 causes RFT1-CDG (CDG-1n) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Sialic acid metabolism Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins	Potassium Channels Voltage gated Potassium channels
Drugs		Oseltamivir
Diseases
GWAS
Protein-Protein Interactions		7 interactors: CTSA EEF1A1 GLB1 JUNB KCNA2 KCNA4 LIG4	16 interactors: ACTN2 CASK DLG1 DLG2 DLG3 DLG4 DLGAP1 ERBB2IP INADL KCNA2 LNX1 NDUFA4L2 NEU1 SAT1 SNTA1 SNTG1
Entrez ID		4758	3739
HPRD ID		09751	01444
Ensembl ID		ENSG00000204386	ENSG00000182255
Uniprot IDs		Q5JQI0 Q99519	P22459
PDB IDs
Enriched GO Terms of Interacting Partners?		Dolichol-linked Oligosaccharide Biosynthetic Process Glycosphingolipid Metabolic Process DNA Ligation Involved In DNA Recombination Protein N-linked Glycosylation Via Asparagine Protein N-linked Glycosylation Optic Nerve Structural Organization Cellular Response To Metal Ion Glycolipid Metabolic Process Cellular Response To Inorganic Substance Sphingolipid Metabolic Process Potassium Ion Transmembrane Transport Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Post-translational Protein Modification Potassium Ion Transport Lagging Strand Elongation Pro-B Cell Differentiation Galactose Catabolic Process Membrane Lipid Metabolic Process Establishment Of Integrated Proviral Latency Protein Homooligomerization Osteoblast Proliferation Immunoglobulin V(D)J Recombination Establishment Of Viral Latency T Cell Receptor V(D)J Recombination Optic Nerve Morphogenesis DNA Ligation Involved In DNA Repair Keratan Sulfate Catabolic Process Lymphoid Progenitor Cell Differentiation Embryonic Process Involved In Female Pregnancy Response To Metal Ion Protein Glycosylation Macromolecule Glycosylation Leukocyte Differentiation Glycosylation DNA Ligation Optic Nerve Development Nucleotide-excision Repair, DNA Gap Filling Biosynthetic Process Cellular Response To Lithium Ion Glycoprotein Biosynthetic Process Anatomical Structure Arrangement Regulation Of Ion Transmembrane Transport Protein Oligomerization Single Strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Dopamine Secretion Glycoprotein Metabolic Process Response To Radiation Galactose Metabolic Process	Receptor Localization To Synapse Nucleotide Phosphorylation Protein Localization To Synapse Synaptic Transmission Establishment Or Maintenance Of Apical/basal Cell Polarity Cell-cell Signaling Receptor Clustering Regulation Of Ion Transmembrane Transport Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Membrane Potential Nucleotide Metabolic Process Regulation Of Ion Transport Nucleobase-containing Small Molecule Metabolic Process Establishment Or Maintenance Of Cell Polarity Organophosphate Metabolic Process Protein Localization To Membrane Cell Communication Cortical Actin Cytoskeleton Organization Positive Regulation Of Potassium Ion Transport Cortical Cytoskeleton Organization Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Ion Transport Cell Junction Assembly Small Molecule Metabolic Process Cell-cell Junction Organization Muscle Contraction Tight Junction Assembly Signaling Protein Homooligomerization Muscle System Process Cellular Component Assembly Negative Regulation Of Phosphatase Activity Regulation Of Vasoconstriction By Circulating Norepinephrine Regulation Of Potassium Ion Transport Regulation Of Sodium Ion Transport Negative Regulation Of Dephosphorylation Apical Junction Assembly Cellular Protein Localization Positive Regulation Of Ion Transmembrane Transport Optic Nerve Structural Organization Spermidine Acetylation Basal Protein Localization Action Potential Sensory Perception Of Pain Membrane Organization Axon Guidance Regulation Of Phosphatase Activity Putrescine Catabolic Process Protein Oligomerization Cellular Localization
Tagcloud ?		ablated archived bloody cadherins cd31 chemodrug dosages grading heterotopic intraperitoneally invasiveness mb mda neovascularization op oseltamivir pecam postimplantation rag2xcgamma ragxcgamma relapses reproducibly shrinking sialidase tetrazolium tnbc tnbcs vascularization wst
Tagcloud (Difference) ?		ablated archived bloody cadherins cd31 chemodrug dosages grading heterotopic intraperitoneally invasiveness mb mda neovascularization op oseltamivir pecam postimplantation rag2xcgamma ragxcgamma relapses reproducibly shrinking sialidase tetrazolium tnbc tnbcs vascularization wst
Tagcloud (Intersection) ?