NEU1 and CERS3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NEU1	CERS3
Description		neuraminidase 1	ceramide synthase 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Lysosome Lysosomal Membrane Plasma Membrane Membrane Cell Junction Cytoplasmic Vesicle Specific Granule Lumen Lysosomal Lumen Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Exo-alpha-sialidase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Alpha-sialidase Activity	DNA Binding Protein Binding Transferase Activity Sphingosine N-acyltransferase Activity
	Biological Process	Lipid Metabolic Process Ganglioside Catabolic Process Oligosaccharide Catabolic Process Lipid Catabolic Process	Lipid Metabolic Process Sphingolipid Metabolic Process Epidermis Development Sphingolipid Biosynthetic Process Keratinocyte Differentiation Ceramide Biosynthetic Process Cornification
Pathways		Sialic acid metabolism Defective NEU1 causes sialidosis Neutrophil degranulation Glycosphingolipid catabolism	Sphingolipid de novo biosynthesis
Drugs		Oseltamivir Celecoxib Acetylsalicylic acid
Diseases		Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD) Sialidosis; Mucolipidosis I Galactosialidosis
GWAS		A body shape index ( 34021172) Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Basal cell carcinoma ( 27539887) Estimated glomerular filtration rate ( 31152163) Inflammatory bowel disease ( 28067908) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Small cell lung carcinoma ( 28604730) Squamous cell lung carcinoma ( 28604730) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172)	Childhood body mass index ( 31752434) Cotinine glucuronidation ( 25293881)
Interacting Genes		30 interacting genes: AQP6 CCR9 CD79A CERS3 CERS4 CREB3 CREB3L1 CTSA EBP EEF1A1 ERGIC3 ERRFI1 GLB1 GOLM1 GPR152 GPX8 HSD17B11 JUNB KCNA2 KCNA4 LIG4 LMNA MGST3 MUC1 SLC10A1 SLC10A6 SLC18A1 SLC39A9 TMEM14B UBC	5 interacting genes: NEU1 ORMDL3 PCBD2 SLC29A2 SLC39A9
Entrez ID		4758	204219
HPRD ID		09751	13961
Ensembl ID		ENSG00000204386	ENSG00000154227
Uniprot IDs		Q5JQI0 Q99519	Q8IU89
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Bile Acid:sodium Symporter Activity Integrated Stress Response Signaling Sphingosine N-acyltransferase Activity Regulation Of Chaperone-mediated Autophagy Lung Vasculature Development Negative Regulation Of Apoptotic Signaling Pathway Vasculature Development RNA Polymerase II Transcription Regulator Complex Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Type B Pancreatic Cell Proliferation Endoplasmic Reticulum Regulation Of Cardiac Muscle Hypertrophy	Cytidine Transmembrane Transporter Activity Uracil Transmembrane Transport Thymine Transport Uridine Transmembrane Transport Inosine Transport Pyrimidine Nucleobase Transmembrane Transport Nucleobase Transmembrane Transporter Activity Cytidine Transport Uracil Transmembrane Transporter Activity Adenine Transmembrane Transporter Activity Purine Nucleoside Transmembrane Transport Guanine Transmembrane Transporter Activity Pyrimidine Nucleoside Transport Guanine Transport Guanine Transmembrane Transport Adenosine Transport Hypoxanthine Transport Nucleoside Transmembrane Transporter Activity Purine Nucleoside Transmembrane Transporter Activity Uridine Transmembrane Transporter Activity Membrane Lipid Metabolic Process Alpha-sialidase Activity Sphingolipid Metabolic Process Ceramide Metabolic Process Exo-alpha-sialidase Activity Regulation Of Cellular Response To Testosterone Stimulus Zinc Efflux Transmembrane Transporter Activity Androgen Binding 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Negative Regulation Of Ceramide Biosynthetic Process Intracellular Sphingolipid Homeostasis Nucleoside Transmembrane Transport Adenine Transport Nucleoside Transport Pyrimidine Nucleobase Transport Negative Regulation Of Sphingolipid Biosynthetic Process Purine Nucleobase Transmembrane Transport Tetrahydrobiopterin Biosynthetic Process Serine Palmitoyltransferase Complex Ganglioside Catabolic Process Tetrahydrobiopterin Metabolic Process Purine Nucleobase Transport Nucleobase Transport Sphingomyelin Biosynthetic Process Pyrimidine-containing Compound Transmembrane Transport Pteridine-containing Compound Biosynthetic Process Negative Regulation Of B Cell Apoptotic Process Regulation Of Ceramide Biosynthetic Process Xenobiotic Transmembrane Transport Oligosaccharide Catabolic Process
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