GDNF and GFRA1

Number of citations of the paper that reports this interaction (PMID 8674117)
98

Data Source:
HPRD (in vitro, in vivo)

		GDNF	GFRA1
Gene Name		glial cell derived neurotrophic factor	GDNF family receptor alpha 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region	Plasma Membrane Extrinsic Component Of Membrane Anchored Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Receptor Binding Growth Factor Activity Protein Homodimerization Activity	Receptor Binding Glial Cell-derived Neurotrophic Factor Receptor Activity
	Biological Process	Metanephros Development Branching Involved In Ureteric Bud Morphogenesis Neural Crest Cell Migration Organ Induction Postsynaptic Membrane Organization Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Signal Transduction Nervous System Development Axon Guidance Adult Locomotory Behavior Postganglionic Parasympathetic Nervous System Development Peristalsis Neuron Projection Development Positive Regulation Of Monooxygenase Activity Positive Regulation Of Dopamine Secretion Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter MRNA Stabilization Enteric Nervous System Development Sympathetic Nervous System Development Regulation Of Dopamine Uptake Involved In Synaptic Transmission Ureteric Bud Formation Regulation Of Morphogenesis Of A Branching Structure Positive Regulation Of Ureteric Bud Formation Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Cell Surface Receptor Signaling Pathway Axon Guidance Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway
Pathways		NCAM1 interactions Axon guidance NCAM signaling for neurite out-growth	NCAM1 interactions Axon guidance NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS		Major depressive disorder ( 20125088)
Protein-Protein Interactions		5 interactors: AGTRAP GFRA1 GFRA2 NCAM1 RET	6 interactors: GDNF NCAM1 NRTN RET SOCS3 TRADD
Entrez ID		2668	2674
HPRD ID		02906	03291
Ensembl ID		ENSG00000168621	ENSG00000151892
Uniprot IDs		P39905	B7Z856 P56159
PDB IDs		2V5E 3FUB
Enriched GO Terms of Interacting Partners?		Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Cellular Response To Organic Substance Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Cytokine Posterior Midgut Development Nervous System Development Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Response To Organic Substance Positive Regulation Of Neuron Maturation Neuron Development Signaling Lymphocyte Migration Into Lymphoid Organs Cell Communication Peyer's Patch Morphogenesis Positive Regulation Of Metanephric Glomerulus Development Neuron Differentiation Ureter Maturation Regulation Of Neuron Maturation Locomotion Angiotensin-activated Signaling Pathway Cellular Response To Stimulus Positive Regulation Of Glomerulus Development Negative Regulation Of Protein Autophosphorylation Movement Of Cell Or Subcellular Component Generation Of Neurons Axon Guidance Enteric Nervous System Development Neurogenesis Neuron Cell-cell Adhesion Positive Regulation Of Cell Size Ureter Development Positive Regulation Of Cell Adhesion Mediated By Integrin Peyer's Patch Development Cell Development System Development Midgut Development Axonogenesis Response To Stimulus Axon Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Protein Autophosphorylation Chemotaxis Neuron Maturation Lymphocyte Migration Multicellular Organismal Development Neuron Projection Morphogenesis	Neural Crest Cell Migration Neural Crest Cell Development Neural Crest Cell Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mesenchymal Cell Development Mesenchymal Cell Differentiation Enteric Nervous System Development Ameboidal-type Cell Migration Regulation Of Extrinsic Apoptotic Signaling Pathway Mesenchyme Development Stem Cell Development Positive Regulation Of Kidney Development Neuron Development Stem Cell Differentiation Autonomic Nervous System Development Anatomical Structure Morphogenesis Neuron Differentiation Axon Guidance Locomotion Signal Transduction Cytokine-mediated Signaling Pathway Morphogenesis Of An Epithelium Signaling Regulation Of Apoptotic Process Axonogenesis Cell Communication Movement Of Cell Or Subcellular Component Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Surface Receptor Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Nerve Development Regulation Of Cell Death Generation Of Neurons Axon Development Cellular Response To Cytokine Stimulus Cell Morphogenesis Involved In Neuron Differentiation Zymogen Activation Metanephros Development Chemotaxis Neurogenesis Cell Differentiation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Ureteric Bud Development Neuron Projection Morphogenesis Mesonephric Tubule Development Mesonephric Epithelium Development Tissue Development Embryonic Morphogenesis Tissue Morphogenesis Interferon-gamma-mediated Signaling Pathway
Tagcloud ?		coimmunoprecipitation crest displays docking enlightening fmtc grb2 hirschsprung inherited isoform isoforms medullar megacolon neurotrophic neurturin oncogenes owing papillary performing phosphopeptides phosphotyrosines proto ptc2 ptc2y620f ptcs rearrangements ret separately shc	amplifies angptl4 antigens autoantibodies autoantibody calibrated capabilities classify conditional conformational deciles dkk1 elicit encode epitopes gal1 grn hosmer humoral inversely lemeshow likelihood lrrc15 minimally muc1 race reflects select sizes
Tagcloud (Difference) ?		coimmunoprecipitation crest displays docking enlightening fmtc grb2 hirschsprung inherited isoform isoforms medullar megacolon neurotrophic neurturin oncogenes owing papillary performing phosphopeptides phosphotyrosines proto ptc2 ptc2y620f ptcs rearrangements ret separately shc	amplifies angptl4 antigens autoantibodies autoantibody calibrated capabilities classify conditional conformational deciles dkk1 elicit encode epitopes gal1 grn hosmer humoral inversely lemeshow likelihood lrrc15 minimally muc1 race reflects select sizes
Tagcloud (Intersection) ?