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GDNF
Description
glial cell derived neurotrophic factor
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Golgi Apparatus
Molecular Function
Signaling Receptor Binding
Protein Binding
Growth Factor Activity
Glial Cell-derived Neurotrophic Factor Receptor Binding
Receptor Tyrosine Kinase Binding
Protein Homodimerization Activity
Chemoattractant Activity Involved In Axon Guidance
Biological Process
Metanephros Development
Ureteric Bud Development
Branching Involved In Ureteric Bud Morphogenesis
Neural Crest Cell Migration
Organ Induction
Postsynaptic Membrane Organization
Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis
Signal Transduction
Nervous System Development
Peripheral Nervous System Development
Positive Regulation Of Cell Population Proliferation
Adult Locomotory Behavior
Tissue Development
Regulation Of Gene Expression
Dorsal Spinal Cord Development
Postganglionic Parasympathetic Fiber Development
Neuron Differentiation
Peristalsis
Neuron Projection Development
Positive Regulation Of Dopamine Secretion
Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway
Negative Regulation Of Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Regulation Of Cell Differentiation
Positive Regulation Of Cell Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
MRNA Stabilization
Enteric Nervous System Development
Sympathetic Nervous System Development
Animal Organ Development
Embryonic Organ Development
Regulation Of Dopamine Uptake Involved In Synaptic Transmission
Ureteric Bud Formation
Regulation Of Morphogenesis Of A Branching Structure
Chemoattraction Of Axon
Commissural Neuron Axon Guidance
Positive Regulation Of Ureteric Bud Formation
Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis
Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis
Regulation Of Stem Cell Differentiation
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Regulation Of Semaphorin-plexin Signaling Pathway
Pathways
NCAM1 interactions
RAF/MAP kinase cascade
RET signaling
Formation of the ureteric bud
Drugs
Chondroitin sulfate
Diseases
Congenital central hypoventilation syndrome (CCHS)
Hirschsprung disease (HD)
GWAS
Asthma (
29273806
)
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
Major depressive disorder (
20125088
)
Interacting Genes
8 interacting genes:
AGTRAP
GFRA1
GFRA2
MUC1
NCAM1
RET
SCAMP5
SYP
Entrez ID
2668
HPRD ID
02906
Ensembl ID
ENSG00000168621
Uniprot IDs
A0A0S2Z3T2
A0A0S2Z3V2
P39905
PDB IDs
2V5E
3FUB
4UX8
6Q2N
Enriched GO Terms of Interacting Partners
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Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway
Glial Cell-derived Neurotrophic Factor Receptor Activity
Side Of Membrane
Plasma Membrane Protein Complex
Extrinsic Component Of Membrane
Receptor Complex
Signaling Receptor Activity
Regulation Of Cell Adhesion Mediated By Integrin
External Side Of Plasma Membrane
Plasma Membrane
Membrane
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Neuron Projection Development
Regulation Of Semaphorin-plexin Signaling Pathway
Posterior Midgut Development
Peyer's Patch Morphogenesis
Positive Regulation Of Metanephric Glomerulus Development
Regulation Of Opioid Receptor Signaling Pathway
Nervous System Development
Neurotrophin Receptor Activity
Ureter Maturation
Synaptic Vesicle Membrane
Angiotensin Type II Receptor Activity
GDF15-GFRAL Signaling Pathway
Positive Regulation Of Glomerulus Development
Kidney Development
Enzyme-linked Receptor Protein Signaling Pathway
Golgi Membrane
Heparan Sulfate Binding
Synaptic Vesicle Maturation
Endosome
Developmental Maturation
Lymphocyte Migration Into Lymphoid Organs
Axon Guidance
Neuron Projection Guidance
Positive Regulation Of Kidney Development
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Negative Regulation Of Cell Adhesion Mediated By Integrin
Regulation Of Synaptic Vesicle Priming
Positive Regulation Of Cell Size
Enteric Nervous System Development
Cytoplasmic Vesicle
Plasma Membrane Bounded Cell Projection Organization
Negative Regulation Of Transcription By Competitive Promoter Binding
Commissural Neuron Axon Guidance
Regulation Of Short-term Neuronal Synaptic Plasticity
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