GDNF and AGTRAP

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		GDNF	AGTRAP
Gene Name		glial cell derived neurotrophic factor	angiotensin II receptor-associated protein
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region	Golgi Membrane Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Plasma Membrane Cell Cortex Integral Component Of Membrane Cytoplasmic Vesicle Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Receptor Binding Growth Factor Activity Protein Homodimerization Activity	Angiotensin Type II Receptor Activity Protein Binding
	Biological Process	Metanephros Development Branching Involved In Ureteric Bud Morphogenesis Neural Crest Cell Migration Organ Induction Postsynaptic Membrane Organization Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Signal Transduction Nervous System Development Axon Guidance Adult Locomotory Behavior Postganglionic Parasympathetic Nervous System Development Peristalsis Neuron Projection Development Positive Regulation Of Monooxygenase Activity Positive Regulation Of Dopamine Secretion Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter MRNA Stabilization Enteric Nervous System Development Sympathetic Nervous System Development Regulation Of Dopamine Uptake Involved In Synaptic Transmission Ureteric Bud Formation Regulation Of Morphogenesis Of A Branching Structure Positive Regulation Of Ureteric Bud Formation Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Response To Hypoxia Regulation Of Blood Pressure Angiotensin-activated Signaling Pathway
Pathways		NCAM1 interactions Axon guidance NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS		Major depressive disorder ( 20125088)	Systolic blood pressure ( 19430483)
Protein-Protein Interactions		5 interactors: AGTRAP GFRA1 GFRA2 NCAM1 RET	70 interactors: ACSF2 ADCK3 AGTR1 AGTR2 ALDH18A1 AP3M1 ARAF ARFIP2 BPIFA2 C12orf10 CAPNS1 CD160 CPLX1 CRCT1 DDA1 DDX55 DGCR6 FAM114A1 FAM160A2 FAM64A FARS2 FASTKD3 FATE1 GABARAPL2 GAD1 GAD2 GDNF GNB2L1 GTF3C1 HARS2 HIST1H4G HMGB1 HSCB HSPA4 ISCU KIAA0368 LMO2 LNX1 MCEE MIEF1 MIEF2 MRM1 MTERF3 MUTYH NDRG4 NFU1 NFYB NKG7 PBX3 PCTP PDHX PITPNC1 PTPN9 RMDN2 SENP2 SNX1 SPG21 SSX3 SSX5 STAG3L1 SUCLA2 SYT16 TBRG4 TCEANC2 TFAM TPD52L3 TUBA1B TXN2 ZFYVE21 ZNF391
Entrez ID		2668	57085
HPRD ID		02906	16379
Ensembl ID		ENSG00000168621	ENSG00000177674
Uniprot IDs		P39905	Q6RW13
PDB IDs		2V5E 3FUB
Enriched GO Terms of Interacting Partners?		Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Cellular Response To Organic Substance Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Cytokine Posterior Midgut Development Nervous System Development Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Response To Organic Substance Positive Regulation Of Neuron Maturation Neuron Development Signaling Lymphocyte Migration Into Lymphoid Organs Cell Communication Peyer's Patch Morphogenesis Positive Regulation Of Metanephric Glomerulus Development Neuron Differentiation Ureter Maturation Regulation Of Neuron Maturation Locomotion Angiotensin-activated Signaling Pathway Cellular Response To Stimulus Positive Regulation Of Glomerulus Development Negative Regulation Of Protein Autophosphorylation Movement Of Cell Or Subcellular Component Generation Of Neurons Axon Guidance Enteric Nervous System Development Neurogenesis Neuron Cell-cell Adhesion Positive Regulation Of Cell Size Ureter Development Positive Regulation Of Cell Adhesion Mediated By Integrin Peyer's Patch Development Cell Development System Development Midgut Development Axonogenesis Response To Stimulus Axon Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Protein Autophosphorylation Chemotaxis Neuron Maturation Lymphocyte Migration Multicellular Organismal Development Neuron Projection Morphogenesis	Succinate Metabolic Process Glutamate Decarboxylation To Succinate Glutamate Metabolic Process Iron-sulfur Cluster Assembly Renin-angiotensin Regulation Of Aldosterone Production Regulation Of Blood Vessel Size By Renin-angiotensin Dicarboxylic Acid Metabolic Process Glutamate Catabolic Process Angiotensin-activated Signaling Pathway Positive Regulation Of Oxidoreductase Activity Positive Regulation Of Protein Homooligomerization Positive Regulation Of Mitochondrial Fission Small Molecule Metabolic Process Negative Regulation Of Phagocytosis Regulation Of Mitochondrial Fission Regulation Of Blood Volume By Renin-angiotensin Dicarboxylic Acid Catabolic Process Neurotransmitter Biosynthetic Process Carboxylic Acid Metabolic Process Regulation Of Oxidoreductase Activity Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Protein Oligomerization Regulation Of Renal Sodium Excretion Regulation Of Branching Involved In Ureteric Bud Morphogenesis Carboxylic Acid Catabolic Process Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Organic Acid Metabolic Process Positive Regulation Of Monooxygenase Activity Regulation Of Excretion Exploration Behavior Regulation Of Protein Oligomerization Neurotransmitter Metabolic Process Neurotransmitter Secretion Mitochondrion Organization Ornithine Biosynthetic Process Negative Regulation Of Apoptotic Cell Clearance Succinyl-CoA Pathway Posterior Compartment Specification Anterior Compartment Pattern Formation Aldosterone Secretion Nitrogen Fixation Vasodilation By Angiotensin Involved In Regulation Of Systemic Arterial Blood Pressure L-methylmalonyl-CoA Metabolic Process Phospholipase C-activating Angiotensin-activated Signaling Pathway Positive Regulation Of Embryonic Development Positive Regulation Of Protein Targeting To Membrane Metanephros Morphogenesis Cellular Amino Acid Catabolic Process Cardiac Muscle Tissue Growth Biosynthetic Process
Tagcloud ?		coimmunoprecipitation crest displays docking enlightening fmtc grb2 hirschsprung inherited isoform isoforms medullar megacolon neurotrophic neurturin oncogenes owing papillary performing phosphopeptides phosphotyrosines proto ptc2 ptc2y620f ptcs rearrangements ret separately shc	adrenal alpha1 apelin apln covers ephx2 epoxide genesis gja1 glands hydrolase hypertensive isolating kynu kynureninase kyoto normotensive osteonectin prone rgs2 rising shr shrsp sparc spock2 substrains urotensin uts2 wky
Tagcloud (Difference) ?		coimmunoprecipitation crest displays docking enlightening fmtc grb2 hirschsprung inherited isoform isoforms medullar megacolon neurotrophic neurturin oncogenes owing papillary performing phosphopeptides phosphotyrosines proto ptc2 ptc2y620f ptcs rearrangements ret separately shc	adrenal alpha1 apelin apln covers ephx2 epoxide genesis gja1 glands hydrolase hypertensive isolating kynu kynureninase kyoto normotensive osteonectin prone rgs2 rising shr shrsp sparc spock2 substrains urotensin uts2 wky
Tagcloud (Intersection) ?