MYH8 and MYBPC2

Number of citations: 48 (PubMedID 23414517)
Data Source: BioGRID (two hybrid)

		MYH8	MYBPC2
Name		myosin heavy chain 8	myosin binding protein C2
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Muscle Myosin Complex Myosin Complex Myosin II Complex Myofibril Sarcomere Myosin Filament	Cytosol M Band Myosin Filament
	Molecular Function	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding Calmodulin Binding ATP Binding Structural Constituent Of Muscle ATP Hydrolysis Activity Myosin Phosphatase Activity Myosin Light Chain Binding Actin Filament Binding	Actin Binding Protein Binding Structural Constituent Of Muscle
	Biological Process	Skeletal Muscle Contraction Muscle Contraction Muscle Filament Sliding ATP Metabolic Process	Cell Adhesion Sarcomere Organization
Pathways		Striated Muscle Contraction	Striated Muscle Contraction
Diseases		Distal arthrogryposis (DA) Trismus-pseudocamptodactyly syndrome; Hecht-Beals Syndrome; Dutch-Kentucky syndrome	None
GWAS		Venous thromboembolism ( 32232851 )	Primary biliary cholangitis ( 26394269 )
Interacting Genes		1 interacting genes: MYBPC2	31 interacting genes: ACTN2 AMOT AOC3 CCT6A CMYA5 COL12A1 DST DYSF FLNB FLNC FSD2 GABARAP GAS7 HSPA1B ITGB5 MAD2L2 MSN MYBPC1 MYBPH MYH8 MYOM2 NF2 PCDH12 PDE4DIP RANBP2 SDCBP SGCG TRIM63 TRIP11 TTN TULP3
Entrez ID		4626	4606
HPRD ID		11760	01184
Ensembl ID		ENSG00000133020	ENSG00000086967
Uniprot IDs		P13535	A0A140VJQ0 Q14324
PDB IDs		Not available	2E7C 2EDK 2EDN
GO Terms Enriched among Interactors		Structural Constituent Of Muscle M Band Sarcomere Organization Myosin Filament Actomyosin Structure Organization	Actin Filament-based Process M Band Actin Cytoskeleton Organization Cytoskeleton Organization Sarcomere Organization Structural Constituent Of Muscle Actomyosin Structure Organization Myosin Filament Z Disc Cytoskeletal Protein Binding Organelle Organization Actin Binding Cytoskeleton Focal Adhesion Titin Binding Positive Regulation Of Organelle Organization Cytoplasm Positive Regulation Of Supramolecular Fiber Organization Cell Adhesion Positive Regulation Of Cytoskeleton Organization Actin Filament Binding Myofibril Positive Regulation Of Microtubule Nucleation Positive Regulation Of Early Endosome To Late Endosome Transport Actin Cytoskeleton Integrin Binding Positive Regulation Of Protein Localization To Early Endosome Regulation Of Organelle Organization Positive Regulation Of Protein Localization To Endosome Positive Regulation Of Cellular Component Biogenesis Muscle Filament Sliding Phosphatidylinositol-4,5-bisphosphate Binding Filopodium Pseudopodium Actin-myosin Filament Sliding Regulation Of Early Endosome To Late Endosome Transport Muscle Contraction Stress Fiber Regulation Of Microtubule Nucleation Regulation Of Supramolecular Fiber Organization Extracellular Exosome Calcium Ion Binding Positive Regulation Of Cellular Component Organization Plasma Membrane Enzyme Binding Muscle Cell Development Sarcolemma Muscle System Process Regulation Of Organelle Assembly Regulation Of Intracellular Transport