SERPINC1 and KLK2

Number of citations of the paper that reports this interaction (PubMedID 9428387)
0

Data Source:
HPRD (in vitro)

		SERPINC1	KLK2
Description		serpin family C member 1	kallikrein related peptidase 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Extracellular Matrix Extracellular Exosome Blood Microparticle	Extracellular Region Extracellular Space Secretory Granule Extracellular Exosome
	Molecular Function	Protease Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Heparin Binding Peptidase Inhibitor Activity Identical Protein Binding	Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Blood Coagulation Hemostasis Regulation Of Blood Coagulation	Regulation Of Systemic Arterial Blood Pressure Proteolysis Zymogen Activation
Pathways		Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Drugs		Ardeparin Fondaparinux Heparin Enoxaparin N-Formylmethionine SR-123781A Sulodexide Danaparoid Dalteparin Tinzaparin Nadroparin Copper Protamine sulfate Bemiparin Antithrombin III human
Diseases		Inherited thrombophilia
GWAS		Experiencing mood swings ( 29500382) Heel bone mineral density ( 30598549)	Celiac disease ( 23936387) PCA3 expression level ( 23555189) Prostate cancer ( 31562322 34012061) Prostate-specific antigen levels ( 23359319 28139693) Prostate-specific antigen levels (conditioned on lead SNPs) ( 28139693) Tandem gait ( 26219847)
Interacting Genes		7 interacting genes: F2 HSP90AA1 KLK1 KLK2 KLK6 PLG SDC2	14 interacting genes: A2M APP AR IGFBP2 POLR2A SEMG1 SEMG2 SERPINA3 SERPINA4 SERPINA5 SERPINB6 SERPINC1 SERPINE1 SERPINF2
Entrez ID		462	3817
HPRD ID		00122	01006
Ensembl ID		ENSG00000117601	ENSG00000167751
Uniprot IDs		P01008	A0A024R4J4 B4DU77 P20151
PDB IDs		1ANT 1ATH 1AZX 1BR8 1DZG 1DZH 1E03 1E04 1E05 1JVQ 1LK6 1NQ9 1OYH 1R1L 1SR5 1T1F 1TB6 2ANT 2B4X 2B5T 2BEH 2GD4 2HIJ 2ZNH 3EVJ 3KCG 4EB1	4NFE 4NFF
Enriched GO Terms of Interacting Partners?		Serine-type Peptidase Activity Serine-type Endopeptidase Activity Protein Processing Peptidase Activity Negative Regulation Of Fibrinolysis Extracellular Exosome Extracellular Space Secretory Granule Regulation Of Fibrinolysis Fibrinolysis Protein Maturation MHC Class II Protein Complex Binding Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Regulation Of Biological Quality Biological Process Involved In Interaction With Symbiont Zymogen Activation Protein Metabolic Process Negative Regulation Of Coagulation Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Extracellular Region Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Albendazole Monooxygenase Activity CTP Binding DATP Binding Regulation Of Systemic Arterial Blood Pressure Tissue Regeneration Hydrolase Activity Cellular Homeostasis Protein Transport Into Plasma Membrane Raft Positive Regulation Of Wound Healing Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Endoplasmic Reticulum Lumen Trimethylamine Monooxygenase Activity Hypotaurine Monooxygenase Activity Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Platelet Alpha Granule Lumen Proteolysis Regulation Of Cardiac Muscle Contraction Striated Muscle Contraction Endopeptidase Activity Rho GDP-dissociation Inhibitor Binding Lysosomal Lumen Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Flavin-dependent Sulfhydryl Oxidase Activity	Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity Protease Binding Extracellular Space Extracellular Exosome Extracellular Region Platelet Alpha Granule Lumen Extracellular Matrix Negative Regulation Of Flagellated Sperm Motility Positive Regulation Of Serine-type Endopeptidase Activity Blood Microparticle Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Serine Protease Inhibitor Complex Endopeptidase Inhibitor Activity Negative Regulation Of Plasminogen Activation Regulation Of Proteolysis Signaling Receptor Binding Positive Regulation Of Endopeptidase Activity Antibacterial Humoral Response Regulation Of Blood Coagulation Regulation Of Hemostasis Positive Regulation Of Peptidase Activity Negative Regulation Of Fibrinolysis Regulation Of Fibrinolysis Regulation Of Plasminogen Activation Regulation Of Flagellated Sperm Motility Regulation Of Endopeptidase Activity Coagulation Platelet Alpha Granule Fibrinolysis Sperm Capacitation Defense Response To Bacterium Negative Regulation Of Protein Processing Positive Regulation Of Monocyte Chemotaxis Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Protein Maturation Molecular Function Activator Activity Regulation Of Wound Healing Positive Regulation Of Blood Coagulation Positive Regulation Of Chemotaxis Positive Regulation Of Coagulation Cell Maturation Regulation Of G Protein-coupled Receptor Signaling Pathway Antimicrobial Humoral Response Heparin Binding Regulation Of Monocyte Chemotaxis Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Bacterium Epithelial Cell Morphogenesis Positive Regulation Of Supramolecular Fiber Organization
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