SERPINC1 and KLK6

Number of citations: 0 (PubMedID 12878203)
Data Source: HPRD (in vitro)

		SERPINC1	KLK6
Name		serpin family C member 1	kallikrein related peptidase 6
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Extracellular Matrix Extracellular Exosome Blood Microparticle	Cornified Envelope Extracellular Region Extracellular Space Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Endoplasmic Reticulum Secretory Granule Nuclear Membrane Intercellular Bridge
	Molecular Function	Protease Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Heparin Binding Peptidase Inhibitor Activity Identical Protein Binding	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Blood Coagulation Hemostasis Regulation Of Blood Coagulation	Proteolysis Central Nervous System Development Response To Wounding Regulation Of Neuron Projection Development Protein Autoprocessing Collagen Catabolic Process Tissue Regeneration Hormone Metabolic Process Myelination Amyloid Precursor Protein Metabolic Process Regulation Of Cell Differentiation Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Protein Maturation
Pathways		Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	None
Drugs		Ardeparin Fondaparinux Heparin Enoxaparin N-Formylmethionine SR-123781A Sulodexide Danaparoid Dalteparin Tinzaparin Nadroparin Copper Protamine sulfate Bemiparin Antithrombin III human	Benzamidine
Diseases		Inherited thrombophilia	None
GWAS		Experiencing mood swings ( 29500382 ) Heel bone mineral density ( 30598549 )	Blood protein levels in cardiovascular risk ( 28369058 )
Novel Interactors		7 novel interactors: ATP1B1 CHML CREG1 FMO3 MRPS14 PIGC QSOX1	None recorded
Interacting Genes		7 interacting genes: F2 HSP90AA1 KLK1 KLK2 KLK6 PLG SDC2	7 interacting genes: LSP1 PALB2 PAX2 SERPINC1 SERPINF2 SNCA TSG101
Entrez ID		462	5653
HPRD ID		00122	04037
Ensembl ID		ENSG00000117601	ENSG00000167755
Uniprot IDs		P01008	Q92876
PDB IDs		1ANT 1ATH 1AZX 1BR8 1DZG 1DZH 1E03 1E04 1E05 1JVQ 1LK6 1NQ9 1OYH 1R1L 1SR5 1T1F 1TB6 2ANT 2B4X 2B5T 2BEH 2GD4 2HIJ 2ZNH 3EVJ 3KCG 4EB1	1GVL 1L2E 1LO6 3VFE 4D8N 5NX1 5NX3 6QFF 6QFG 6QFH 6QH9 6QHA 6QHB 6QHC 6SKB 6SKC 6SKD 7QFT 7QFV 7QHZ 7QI0
GO Terms Enriched among Interactors		Serine-type Peptidase Activity Serine-type Endopeptidase Activity Protein Processing Peptidase Activity Negative Regulation Of Fibrinolysis Extracellular Exosome Extracellular Space Secretory Granule Regulation Of Fibrinolysis Fibrinolysis Protein Maturation MHC Class II Protein Complex Binding Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Regulation Of Biological Quality Biological Process Involved In Interaction With Symbiont Zymogen Activation Protein Metabolic Process Negative Regulation Of Coagulation Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Extracellular Region Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Albendazole Monooxygenase Activity CTP Binding DATP Binding Regulation Of Systemic Arterial Blood Pressure Tissue Regeneration Hydrolase Activity Cellular Homeostasis Protein Transport Into Plasma Membrane Raft Positive Regulation Of Wound Healing Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Endoplasmic Reticulum Lumen Trimethylamine Monooxygenase Activity Hypotaurine Monooxygenase Activity Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Platelet Alpha Granule Lumen Proteolysis Regulation Of Cardiac Muscle Contraction Striated Muscle Contraction Endopeptidase Activity Rho GDP-dissociation Inhibitor Binding Lysosomal Lumen Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Flavin-dependent Sulfhydryl Oxidase Activity	Peptidase Inhibitor Activity Regulation Of Hemostasis Protease Binding Regulation Of Blood Coagulation Serine-type Endopeptidase Inhibitor Activity Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephric Nephron Morphogenesis Pronephric Field Specification Negative Regulation Of Apoptotic Process Involved In Metanephric Nephron Tubule Development Optic Chiasma Development Positive Regulation Of Optic Nerve Formation Regulation Of Metanephros Size Optic Nerve Structural Organization Negative Regulation Of Apoptotic Process Involved In Metanephric Collecting Duct Development Positive Regulation Of Metanephric DCT Cell Differentiation Optic Cup Morphogenesis Involved In Camera-type Eye Development Positive Regulation Of Cellular Component Biogenesis Response To Desipramine Positive Regulation Of Exocytosis Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Regulation Of Norepinephrine Uptake Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Establishment Of Vesicle Localization Positive Regulation Of Ubiquitin-dependent Endocytosis Regulation Of Wound Healing Blood Microparticle Regulation Of Reactive Oxygen Species Metabolic Process Vestibulocochlear Nerve Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Nephron Morphogenesis Metanephric Nephron Tubule Formation Metanephric Distal Convoluted Tubule Development Nephric Duct Formation Positive Regulation Of Metanephric Glomerulus Development Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Ureter Maturation Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Negative Regulation Of Protein Metabolic Process Negative Regulation Of Dopamine Metabolic Process Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Vesicle Localization Regulation Of Serotonin Uptake Exosomal Secretion Positive Regulation Of Viral Budding Via Host ESCRT Complex Optic Nerve Morphogenesis Metanephric Tubule Formation